Institution
Uppsala University
Education•Uppsala, Sweden•
About: Uppsala University is a education organization based out in Uppsala, Sweden. It is known for research contribution in the topics: Population & Gene. The organization has 36485 authors who have published 107509 publications receiving 4220668 citations. The organization is also known as: Uppsala universitet & uu.se.
Topics: Population, Gene, Context (language use), Thin film, Receptor
Papers published on a yearly basis
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TL;DR: It is confirmed that reduced fetal growth is associated with increased risk of diabetes and suggest a specific association with thinness at birth and this relation seems to be mediated through insulin resistance rather than through impaired β cell function and to depend on an interaction with obesity in adult life.
Abstract: Objective: To establish whether the relation between size at birth and non-insulin dependent diabetes is mediated through impaired β cell function or insulin resistance. Design: Cohort study. Setting: Uppsala, Sweden. Subjects: 1333 men whose birth records were traced from a cohort of 2322 men born during 1920-4 and resident in Uppsala in 1970. Main outcome measures: Intravenous glucose tolerance test at age 50 years and non-insulin dependent diabetes at age 60 years. Results: There was a weak inverse correlation (r=-0.07, P=0.03) between ponderal index at birth and 60 minute insulin concentrations in the intravenous glucose tolerance test at age 50 years. This association was stronger (r=-0.19, P=0.001) in the highest third of the distribution of body mass index than in the other two thirds (P=0.01 for the interaction between ponderal index and body mass index). Prevalence of diabetes at age 60 years was 8% in men whose birth weight was less than 3250 g compared with 5% in men with birth weight 3250 g or more (P=0.08; 95% confidence interval for difference −0.3% to 6.8%). There was a stronger association between diabetes and ponderal index: prevalence of diabetes was 12% in the lowest fifth of ponderal index compared with 4% in the other four fifths (P=0.001; 3.0% to 12.6%). Conclusion: These results confirm that reduced fetal growth is associated with increased risk of diabetes and suggest a specific association with thinness at birth. This relation seems to be mediated through insulin resistance rather than through impaired β cell function and to depend on an interaction with obesity in adult life.
748 citations
TL;DR: Ghauri et al. as discussed by the authors used a longitudinal case study of four manufacturing firms in a small open economy such as New Zealand to identify the theoretical gap in the literature, which is the focus on organically developed networks rather than formal structured ones.
746 citations
Broad Institute1, University of Pavia2, Uppsala University3, University of Bologna4, University of Kentucky5, University of Adelaide6, University of Tampa7, University of Veterinary Medicine Vienna8, University of Bern9, University of California, Davis10, Wellcome Trust Sanger Institute11, Cornell University12, Royal Veterinary College13, Institut national de la recherche agronomique14, Japan Racing Association15, University College Dublin16, Genetic Information Research Institute17, Swedish University of Agricultural Sciences18, University of Minnesota19, University of Bari20, Texas A&M University21, Animal Health Trust22, Massachusetts Institute of Technology23
TL;DR: The analysis reveals an evolutionarily new centromere on equine chromosome 11 that displays properties of an immature but fully functioning Centromere and is devoid of centromeric satellite sequence, suggesting thatCentromeric function may arise before satellite repeat accumulation.
Abstract: We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.
745 citations
TL;DR: The authors have adopted a new nomenclature for the laminins, in which the previous A, B1 and B2 chains, and their isoforms, are alpha, beta and gamma, followed by an arabic numeral to identify the isoform.
743 citations
TL;DR: The whole-genome re-sequencing of 120 individuals representing all of the Darwin’s finch species and two close relatives finds extensive evidence for interspecific gene flow throughout the radiation.
Abstract: Darwin's finches, inhabiting the Galapagos archipelago and Cocos Island, constitute an iconic model for studies of speciation and adaptive evolution. Here we report the results of whole-genome re-s ...
743 citations
Authors
Showing all 36854 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Zhong Lin Wang | 245 | 2529 | 259003 |
| Lewis C. Cantley | 196 | 748 | 169037 |
| Darien Wood | 160 | 2174 | 136596 |
| Kaj Blennow | 160 | 1845 | 116237 |
| Christopher J. O'Donnell | 159 | 869 | 126278 |
| Tomas Hökfelt | 158 | 1033 | 95979 |
| Peter G. Schultz | 156 | 893 | 89716 |
| Frederik Barkhof | 154 | 1449 | 104982 |
| Deepak L. Bhatt | 149 | 1973 | 114652 |
| Svante Pääbo | 147 | 407 | 84489 |
| Jan-Åke Gustafsson | 147 | 1058 | 98804 |
| Hans-Olov Adami | 145 | 908 | 83473 |
| Hermann Kolanoski | 145 | 1279 | 96152 |
| Kjell Fuxe | 142 | 1479 | 89846 |
| Jan Conrad | 141 | 826 | 71445 |