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Institution

Utrecht University

EducationUtrecht, Utrecht, Netherlands
About: Utrecht University is a education organization based out in Utrecht, Utrecht, Netherlands. It is known for research contribution in the topics: Population & Poison control. The organization has 58176 authors who have published 139351 publications receiving 6214282 citations. The organization is also known as: UU & Universiteit Utrecht.


Papers
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Journal ArticleDOI
18 Feb 2017-Cancers
TL;DR: An overview of the clinical trials conducted over the last 10 years is provided, illustrating how PDT is applied in the clinic today, and the factors that hamper the exploration of this effective therapy and what should be changed to render it a more effective and more widely available option for patients.
Abstract: Photodynamic therapy (PDT) is a clinically approved cancer therapy, based on a photochemical reaction between a light activatable molecule or photosensitizer, light, and molecular oxygen. When these three harmless components are present together, reactive oxygen species are formed. These can directly damage cells and/or vasculature, and induce inflammatory and immune responses. PDT is a two-stage procedure, which starts with photosensitizer administration followed by a locally directed light exposure, with the aim of confined tumor destruction. Since its regulatory approval, over 30 years ago, PDT has been the subject of numerous studies and has proven to be an effective form of cancer therapy. This review provides an overview of the clinical trials conducted over the last 10 years, illustrating how PDT is applied in the clinic today. Furthermore, examples from ongoing clinical trials and the most recent preclinical studies are presented, to show the directions, in which PDT is headed, in the near and distant future. Despite the clinical success reported, PDT is still currently underutilized in the clinic. We also discuss the factors that hamper the exploration of this effective therapy and what should be changed to render it a more effective and more widely available option for patients.

683 citations

Journal ArticleDOI
TL;DR: It is demonstrated that suppression of T cell function can be accomplished by a subset of human neutrophils that can be systemically induced in response to acute inflammation.
Abstract: Suppression of immune responses is necessary to limit damage to host tissue during inflammation, but it can be detrimental in specific immune responses, such as sepsis and antitumor immunity. Recently, immature myeloid cells have been implicated in the suppression of immune responses in mouse models of cancer, infectious disease, bone marrow transplantation, and autoimmune disease. Here, we report the identification of a subset of mature human neutrophils (CD11cbright/CD62Ldim/CD11bbright/CD16bright) as what we believe to be a unique circulating population of myeloid cells, capable of suppressing human T cell proliferation. These cells were observed in humans in vivo during acute systemic inflammation induced by endotoxin challenge or by severe injury. Local release of hydrogen peroxide from the neutrophils into the immunological synapse between the neutrophils and T cells mediated the suppression of T cell proliferation and required neutrophil expression of the integrin Mac-1 (αMβ2). Our data demonstrate that suppression of T cell function can be accomplished by a subset of human neutrophils that can be systemically induced in response to acute inflammation. Identification of the pivotal role of neutrophil Mac-1 and ROS in this process provides a potential target for modulating immune responses in humans.

683 citations

Journal ArticleDOI
TL;DR: The current state of native mass spectrometry technology is reviewed and several important biological applications are discussed, including high-throughput interactomics studies and current experimental challenges.
Abstract: Native mass spectrometry is an emerging technology that allows the topological investigation of intact protein complexes with high sensitivity and a theoretically unrestricted mass range. This unique tool provides complementary information to established technologies in structural biology, and also provides a link to high-throughput interactomics studies, which do not generate information on exact protein complex-composition, structure or dynamics. Here I review the current state of native mass spectrometry technology and discuss several important biological applications. I also describe current experimental challenges in native mass spectrometry, encouraging readers to contribute to solutions.

682 citations

Journal ArticleDOI
TL;DR: Lowered cognitive performance in diabetic patients appeared to be associated with the presence of microvascular complications but not with the occurrence of severe hypoglycemic episodes or with poor metabolic control.
Abstract: OBJECTIVE —To investigate the exact nature and magnitude of cognitive impairments in patients with type 1 diabetes and the possible association with other disease variables, such as recurrent episodes of hypoglycemia and metabolic control. RESEARCH DESIGN AND METHODS —MedLine and PsycLit search engines were used to identify studies on cognitive performance in patients with type 1 diabetes. Effect sizes (Cohen’s d ), which are the standardized differences between the experimental and the control group, were calculated. In the meta-analysis, a combined d value was calculated, expressing the magnitude of associations across studies. RESULTS —A total of 33 studies were identified that met the inclusion criteria. Compared with nondiabetic control subjects, the type 1 diabetic group demonstrated a significantly lowered performance on the following cognitive domains: intelligence ( d = −0.7), speed of information processing ( d = −0.3), psychomotor efficiency ( d = −0.6), visual ( d = −0.4) and sustained attention ( d = −0.3), cognitive flexibility ( d = −0.5), and visual perception ( d = −0.4). Lowered cognitive performance in diabetic patients appeared to be associated with the presence of microvascular complications but not with the occurrence of severe hypoglycemic episodes or with poor metabolic control. CONCLUSIONS —In patients with type 1 diabetes, cognitive dysfunction is characterized by a slowing of mental speed and a diminished mental flexibility, whereas learning and memory are spared.The magnitude of the cognitive deficits is mild to moderate, but even mild forms of cognitive dysfunction might hamper everyday activities since they can be expected to present problems in more demanding situations.

681 citations

Journal ArticleDOI
TL;DR: The contrast sensitivity of the human eye for sinusoidal illuminance changes was measured as a function of spatial frequency, for monochromatic light with wavelengths of 450, 525, and 650 nm as discussed by the authors.
Abstract: The contrast sensitivity of the human eye for sinusoidal illuminance changes was measured as a function of spatial frequency, for monochromatic light with wavelengths of 450, 525, and 650 nm. At each wavelength, data were obtained for a number of illuminance levels. All observations were taken at equal accommodation, and corrected for chromatic aberration. If the wavelength-dependent effects of diffraction on the modulation transfer are taken into account, no difference is found between the photopic contrast-sensitivity functions for red, green, or blue. For mean retinal illuminances B0 smaller than 300 td, threshold modulation M at a given frequency is found to increase in proportion to B0-12 (de Vries–Rose law). For B0 greater than 300 td M remains a constant fraction of it (Weber–Fechner law). After separation of the optical modulation transfer of the eye media from the measured psychophysical data, the remaining function can be considered as composed of a neural and a light-diffusion transfer function. The latter can be compared with the analytic transfer function of photographic film.

679 citations


Authors

Showing all 58756 results

NameH-indexPapersCitations
Ronald C. Kessler2741332328983
Albert Hofman2672530321405
Douglas G. Altman2531001680344
Hans Clevers199793169673
Craig B. Thompson195557173172
Patrick W. Serruys1862427173210
Ruedi Aebersold182879141881
Dennis S. Charney179802122408
Kenneth S. Kendler1771327142251
Jean Louis Vincent1611667163721
Vilmundur Gudnason159837123802
Monique M.B. Breteler15954693762
Lex M. Bouter158767103034
Elio Riboli1581136110499
Roy F. Baumeister157650132987
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023429
20221,014
20218,992
20208,578
20197,862
20187,020