Utrecht University

About: Utrecht University is a education organization based out in Utrecht, Utrecht, Netherlands. It is known for research contribution in the topics: Population & Poison control. The organization has 58176 authors who have published 139351 publications receiving 6214282 citations. The organization is also known as: UU & Universiteit Utrecht.

Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry

Abstract: The annotated genomes of organisms define a 'blueprint' of their possible gene products. Post-genome analyses attempt to confirm and modify the annotation and impose a sense of the spatial, temporal and developmental usage of genetic information by the organism. Here we describe a large-scale, high-accuracy (average deviation less than 0.02 Da at 1,000 Da) mass spectrometric proteome analysis of selected stages of the human malaria parasite Plasmodium falciparum. The analysis revealed 1,289 proteins of which 714 proteins were identified in asexual blood stages, 931 in gametocytes and 645 in gametes. The last two groups provide insights into the biology of the sexual stages of the parasite, and include conserved, stage-specific, secreted and membrane-associated proteins. A subset of these proteins contain domains that indicate a role in cell-cell interactions, and therefore can be evaluated as potential components of a malaria vaccine formulation. We also report a set of peptides with significant matches in the parasite genome but not in the protein set predicted by computational methods.

Introduction to Stellar Winds

Abstract: Preface 1. Historical overview 2. Observations of stellar winds 3. Basic concepts: isothermal winds 4. Basic concepts: non-isothermal winds 5. Coronal winds 6. Sound wave driven winds 7. Dust driven winds 8. Line driven winds 9. Magnetic rotator theory 10. Alfven wave driven winds 11. Outflowing disks from rotating stars 12. Winds colliding with the interstellar medium 13. The effects of mass loss on stellar evolution 14. Problems Appendices Bibliography Object index Index.

Iterative Krylov Methods for Large Linear Systems

Abstract: Preface 1. Introduction 2. Mathematical preliminaries 3. Basic iteration methods 4. Construction of approximate solutions 5. The conjugate gradients method 6. GMRES and MINRES 7. Bi-conjugate gradients 8. How serious is irregular convergence? 9. BI-CGSTAB 10. Solution of singular systems 11. Solution of f (A)x = b with Krylov subspace information 12. Miscellaneous 13. Preconditioning References Index.