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Institution

Utrecht University

EducationUtrecht, Utrecht, Netherlands
About: Utrecht University is a education organization based out in Utrecht, Utrecht, Netherlands. It is known for research contribution in the topics: Population & Poison control. The organization has 58176 authors who have published 139351 publications receiving 6214282 citations. The organization is also known as: UU & Universiteit Utrecht.


Papers
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Journal ArticleDOI
TL;DR: In this paper, the authors provided a global overview of groundwater depletion by assessing groundwater recharge with a global hydrological model and subtracting estimates of groundwater abstraction, and they estimated the total global groundwater depletion to have increased from 126 (±32) km3 a−1 in 1960 to 283 (±40) km 3 a −1 in 2000.
Abstract: [1] In regions with frequent water stress and large aquifer systems groundwater is often used as an additional water source. If groundwater abstraction exceeds the natural groundwater recharge for extensive areas and long times, overexploitation or persistent groundwater depletion occurs. Here we provide a global overview of groundwater depletion (here defined as abstraction in excess of recharge) by assessing groundwater recharge with a global hydrological model and subtracting estimates of groundwater abstraction. Restricting our analysis to sub-humid to arid areas we estimate the total global groundwater depletion to have increased from 126 (±32) km3 a−1 in 1960 to 283 (±40) km3 a−1 in 2000. The latter equals 39 (±10)% of the global yearly groundwater abstraction, 2 (±0.6)% of the global yearly groundwater recharge, 0.8 (±0.1)% of the global yearly continental runoff and 0.4 (±0.06)% of the global yearly evaporation, contributing a considerable amount of 0.8 (±0.1) mm a−1 to current sea-level rise.

1,367 citations

Journal ArticleDOI
TL;DR: Current issues are laid out and the areas of consensus and controversy surrounding the evolution of plasticity and the reaction norm (the set of phenotypes produced by a genotype over a range of environments) are summarized.
Abstract: Phenotypic plasticity is an environmentally based change in the phenotype. Understanding the evolution of adaptive phenotypic plasticity has been hampered by dissenting opinions on the merits of different methods of description, on the underlying genetic mechanisms, and on the way that plasticity is affected by natural selection in a heterogeneous environment. During much of this debate, the authors of this article have held opposing views. Here, we attempt to lay out current issues and summarize the areas of consensus and controversy surrounding the evolution of plasticity and the reaction norm (the set of phenotypes produced by a genotype over a range of environments).

1,361 citations

Journal ArticleDOI
22 Jun 2018-Science
TL;DR: It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
Abstract: Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.

1,357 citations

Journal ArticleDOI
TL;DR: These data show that lumacaftor in combination with ivacaftors provided a benefit for patients with cystic fibrosis homozygous for the Phe508del CFTR mutation.
Abstract: A total of 1108 patients underwent randomization and received study drug. The mean baseline FEV 1 was 61% of the predicted value. In both studies, there were significant improvements in the primary end point in both lumacaftor–ivacaftor dose groups; the difference between active treatment and placebo with respect to the mean absolute improvement in the percentage of predicted FEV 1 ranged from 2.6 to 4.0 percentage points (P<0.001), which corresponded to a mean relative treatment difference of 4.3 to 6.7% (P<0.001). Pooled analyses showed that the rate of pulmonary exacerbations was 30 to 39% lower in the lumacaftor–ivacaftor groups than in the placebo group; the rate of events leading to hospitalization or the use of intravenous antibiotics was lower in the lumacaftor–ivacaftor groups as well. The incidence of adverse events was generally similar in the lumacaftor–ivacaftor and placebo groups. The rate of discontinuation due to an adverse event was 4.2% among patients who received lumacaftor–ivacaftor versus 1.6% among those who received placebo. CONCLUSIONS These data show that lumacaftor in combination with ivacaftor provided a benefit for patients with cystic fibrosis homozygous for the Phe508del CFTR mutation. (Funded by Vertex Pharmaceuticals and others; TRAFFIC and TRANSPORT ClinicalTrials.gov numbers, NCT01807923 and NCT01807949.)

1,355 citations

Journal ArticleDOI
TL;DR: The contaminant repository for affinity purification (the CRAPome) is presented and its use for scoring protein-protein interactions is described and aggregating negative controls from multiple AP-MS studies can increase coverage and improve the characterization of background associated with a given experimental protocol.
Abstract: Affinity purification coupled with mass spectrometry (AP-MS) is a widely used approach for the identification of protein-protein interactions. However, for any given protein of interest, determining which of the identified polypeptides represent bona fide interactors versus those that are background contaminants (for example, proteins that interact with the solid-phase support, affinity reagent or epitope tag) is a challenging task. The standard approach is to identify nonspecific interactions using one or more negative-control purifications, but many small-scale AP-MS studies do not capture a complete, accurate background protein set when available controls are limited. Fortunately, negative controls are largely bait independent. Hence, aggregating negative controls from multiple AP-MS studies can increase coverage and improve the characterization of background associated with a given experimental protocol. Here we present the contaminant repository for affinity purification (the CRAPome) and describe its use for scoring protein-protein interactions. The repository (currently available for Homo sapiens and Saccharomyces cerevisiae) and computational tools are freely accessible at http://www.crapome.org/.

1,355 citations


Authors

Showing all 58756 results

NameH-indexPapersCitations
Ronald C. Kessler2741332328983
Albert Hofman2672530321405
Douglas G. Altman2531001680344
Hans Clevers199793169673
Craig B. Thompson195557173172
Patrick W. Serruys1862427173210
Ruedi Aebersold182879141881
Dennis S. Charney179802122408
Kenneth S. Kendler1771327142251
Jean Louis Vincent1611667163721
Vilmundur Gudnason159837123802
Monique M.B. Breteler15954693762
Lex M. Bouter158767103034
Elio Riboli1581136110499
Roy F. Baumeister157650132987
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023429
20221,014
20218,992
20208,578
20197,862
20187,020