Institution
Utrecht University
Education•Utrecht, Utrecht, Netherlands•
About: Utrecht University is a education organization based out in Utrecht, Utrecht, Netherlands. It is known for research contribution in the topics: Population & Poison control. The organization has 58176 authors who have published 139351 publications receiving 6214282 citations. The organization is also known as: UU & Universiteit Utrecht.
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Harvard University1, National Institutes of Health2, University of California, Davis3, Leipzig University4, Universidad Autónoma Metropolitana5, State University of New York System6, Academy for Urban School Leadership7, Utrecht University8, University College Hospital, Ibadan9, St George's Hospital10, The Chinese University of Hong Kong11, Mental Health Services12, Keio University13
TL;DR: Mental health care in 17 countries participating in the WHO world mental health survey initiative is described and unmet needs for treatment are examined, especially concerning in less-developed countries.
1,304 citations
TL;DR: Synaptic connectivity does not depend on neurotransmitter secretion, but its maintenance does, and neurotransmitter secretion probably functions to validate already established synaptic connections.
Abstract: Brain function requires precisely orchestrated connectivity between neurons. Establishment of these connections is believed to require signals secreted from outgrowing axons, followed by synapse formation between selected neurons. Deletion of a single protein, Munc18-1, in mice leads to a complete loss of neurotransmitter secretion from synaptic vesicles throughout development. However, this does not prevent normal brain assembly, including formation of layered structures, fiber pathways, and morphologically defined synapses. After assembly is completed, neurons undergo apoptosis, leading to widespread neurodegeneration. Thus, synaptic connectivity does not depend on neurotransmitter secretion, but its maintenance does. Neurotransmitter secretion probably functions to validate already established synaptic connections.
1,302 citations
Potsdam Institute for Climate Impact Research1, International Livestock Research Institute2, Norwegian Water Resources and Energy Directorate3, University of Reading4, Met Office5, University of Kassel6, City College of New York7, International Centre for Theoretical Physics8, University of Nottingham9, University of Tokyo10, Chinese Academy of Sciences11, National Institute for Environmental Studies12, Goethe University Frankfurt13, American Museum of Natural History14, Max Planck Society15, Utrecht University16, University of Bonn17
TL;DR: It is shown that climate change is likely to exacerbate regional and global water scarcity considerably and GHM uncertainty is particularly dominant in many regions affected by declining water resources, suggesting a high potential for improved water resource projections through hydrological model development.
Abstract: Water scarcity severely impairs food security and economic prosperity in many countries today. Expected future population changes will, in many countries as well as globally, increase the pressure on available water resources. On the supply side, renewable water resources will be affected by projected changes in precipitation patterns, temperature, and other climate variables. Here we use a large ensemble of global hydrological models (GHMs) forced by five global climate models and the latest greenhouse-gas concentration scenarios (Representative Concentration Pathways) to synthesize the current knowledge about climate change impacts on water resources. We show that climate change is likely to exacerbate regional and global water scarcity considerably. In particular, the ensemble average projects that a global warming of 2 °C above present (approximately 2.7 °C above preindustrial) will confront an additional approximate 15% of the global population with a severe decrease in water resources and will increase the number of people living under absolute water scarcity (<500 m3 per capita per year) by another 40% (according to some models, more than 100%) compared with the effect of population growth alone. For some indicators of moderate impacts, the steepest increase is seen between the present day and 2 °C, whereas indicators of very severe impacts increase unabated beyond 2 °C. At the same time, the study highlights large uncertainties associated with these estimates, with both global climate models and GHMs contributing to the spread. GHM uncertainty is particularly dominant in many regions affected by declining water resources, suggesting a high potential for improved water resource projections through hydrological model development.
1,295 citations
TL;DR: This poster presents a poster presented at the 2016 International Congress of the American College of Vascular Surgery (ICS) entitled “Cardiology and Vascular Surgeons: Foundations of Cardiac Rhythm Management, 2nd Ed.”
1,291 citations
Wellcome Trust Sanger Institute1, Université de Montréal2, University of Edinburgh3, University of Kiel4, Karolinska Institutet5, Cedars-Sinai Medical Center6, University of Cambridge7, University of Pennsylvania8, Casa Sollievo della Sofferenza9, University of Pittsburgh10, Université libre de Bruxelles11, University of Otago12, Johns Hopkins University13, Ludwig Maximilian University of Munich14, Charité15, Lille University of Science and Technology16, Cincinnati Children's Hospital Medical Center17, Ghent University18, Torbay Hospital19, University of Groningen20, Mater Health Services21, University of Liège22, University of Washington23, University of Utah24, QIMR Berghofer Medical Research Institute25, University of Paris26, University of Western Australia27, Tel Aviv University28, University of Dundee29, Harvard University30, University of Manchester31, Utrecht University32, University of Florence33, King's College London34, Yale University35, Royal Hospital for Sick Children36, Katholieke Universiteit Leuven37, Guy's and St Thomas' NHS Foundation Trust38, University of Barcelona39, University of Chicago40, University of Bern41, University of California, San Francisco42, Agency for Science, Technology and Research43, University of Toronto44, University of Oslo45, Leiden University46, University of Amsterdam47, Aarhus University48, National and Kapodistrian University of Athens49, Lithuanian University of Health Sciences50, Newcastle University51, Emory University52, Örebro University53, French Institute of Health and Medical Research54, Center for Applied Genomics55
TL;DR: A meta-analysis of six ulcerative colitis genome-wide association study datasets found many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1.
Abstract: Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 × 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.
1,291 citations
Authors
Showing all 58756 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Ronald C. Kessler | 274 | 1332 | 328983 |
| Albert Hofman | 267 | 2530 | 321405 |
| Douglas G. Altman | 253 | 1001 | 680344 |
| Hans Clevers | 199 | 793 | 169673 |
| Craig B. Thompson | 195 | 557 | 173172 |
| Patrick W. Serruys | 186 | 2427 | 173210 |
| Ruedi Aebersold | 182 | 879 | 141881 |
| Dennis S. Charney | 179 | 802 | 122408 |
| Kenneth S. Kendler | 177 | 1327 | 142251 |
| Jean Louis Vincent | 161 | 1667 | 163721 |
| Vilmundur Gudnason | 159 | 837 | 123802 |
| Monique M.B. Breteler | 159 | 546 | 93762 |
| Lex M. Bouter | 158 | 767 | 103034 |
| Elio Riboli | 158 | 1136 | 110499 |
| Roy F. Baumeister | 157 | 650 | 132987 |