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Institution

Utrecht University

EducationUtrecht, Utrecht, Netherlands
About: Utrecht University is a education organization based out in Utrecht, Utrecht, Netherlands. It is known for research contribution in the topics: Population & Context (language use). The organization has 58176 authors who have published 139351 publications receiving 6214282 citations. The organization is also known as: UU & Universiteit Utrecht.


Papers
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Journal ArticleDOI
TL;DR: These novel schemes use an additive operator splitting (AOS), which guarantees equal treatment of all coordinate axes, can be implemented easily in arbitrary dimensions, have good rotational invariance and reveal a computational complexity and memory requirement which is linear in the number of pixels.
Abstract: Nonlinear diffusion filtering in image processing is usually performed with explicit schemes. They are only stable for very small time steps, which leads to poor efficiency and limits their practical use. Based on a discrete nonlinear diffusion scale-space framework we present semi-implicit schemes which are stable for all time steps. These novel schemes use an additive operator splitting (AOS), which guarantees equal treatment of all coordinate axes. They can be implemented easily in arbitrary dimensions, have good rotational invariance and reveal a computational complexity and memory requirement which is linear in the number of pixels. Examples demonstrate that, under typical accuracy requirements, AOS schemes are at least ten times more efficient than the widely used explicit schemes.

1,229 citations

Journal ArticleDOI
TL;DR: The CRISPR/Cas9 genome editing system is used to correct the CFTR locus by homologous recombination in cultured intestinal stem cells of CF patients and the corrected allele is expressed and fully functional as measured in clonally expanded organoids.

1,226 citations

Journal ArticleDOI
20 Apr 2007-Science
TL;DR: Olivine phenocrysts' compositions record differences in the contributions of pyroxenite-derived melts in mid-ocean ridge basalts, which imply involvement of 2 to 20% (up to 28%) of recycled crust in mantle melting.
Abstract: Plate tectonic processes introduce basaltic crust (as eclogite) into the peridotitic mantle. The proportions of these two sources in mantle melts are poorly understood. Silica-rich melts formed from eclogite react with peridotite, converting it to olivine-free pyroxenite. Partial melts of this hybrid pyroxenite are higher in nickel and silicon but poorer in manganese, calcium, and magnesium than melts of peridotite. Olivine phenocrysts' compositions record these differences and were used to quantify the contributions of pyroxenite-derived melts in mid-ocean ridge basalts (10 to 30%), ocean island and continental basalts (many >60%), and komatiites (20 to 30%). These results imply involvement of 2 to 20% (up to 28%) of recycled crust in mantle melting.

1,226 citations

Journal ArticleDOI
TL;DR: Large-scale molecular surveys have provided novel insights into the diversity, spatial and temporal dynamics of mycorrhizal fungal communities, and network theory makes it possible to analyze interactions between plant-fungal partners as complex underground multi-species networks.
Abstract: Almost all land plants form symbiotic associations with mycorrhizal fungi. These below-ground fungi play a key role in terrestrial ecosystems as they regulate nutrient and carbon cycles, and influence soil structure and ecosystem multifunctionality. Up to 80% of plant N and P is provided by mycorrhizal fungi and many plant species depend on these symbionts for growth and survival. Estimates suggest that there are c. 50 000 fungal species that form mycorrhizal associations with c. 250 000 plant species. The development of high-throughput molecular tools has helped us to better understand the biology, evolution, and biodiversity of mycorrhizal associations. Nuclear genome assemblies and gene annotations of 33 mycorrhizal fungal species are now available providing fascinating opportunities to deepen our understanding of the mycorrhizal lifestyle, the metabolic capabilities of these plant symbionts, the molecular dialogue between symbionts, and evolutionary adaptations across a range of mycorrhizal associations. Large-scale molecular surveys have provided novel insights into the diversity, spatial and temporal dynamics of mycorrhizal fungal communities. At the ecological level, network theory makes it possible to analyze interactions between plant-fungal partners as complex underground multi-species networks. Our analysis suggests that nestedness, modularity and specificity of mycorrhizal networks vary and depend on mycorrhizal type. Mechanistic models explaining partner choice, resource exchange, and coevolution in mycorrhizal associations have been developed and are being tested. This review ends with major frontiers for further research.

1,223 citations

Journal ArticleDOI
TL;DR: The International Lipid Classification and Nomenclature Committee under the sponsorship of the LIPID MAPS Consortium developed and established a "Comprehensive Classification System for Lipids" based on well defined chemical and biochemical principles and using an ontology that is extensible, flexible, and scalable as mentioned in this paper.

1,219 citations


Authors

Showing all 58756 results

NameH-indexPapersCitations
Ronald C. Kessler2741332328983
Albert Hofman2672530321405
Douglas G. Altman2531001680344
Hans Clevers199793169673
Craig B. Thompson195557173172
Patrick W. Serruys1862427173210
Ruedi Aebersold182879141881
Dennis S. Charney179802122408
Kenneth S. Kendler1771327142251
Jean Louis Vincent1611667163721
Vilmundur Gudnason159837123802
Monique M.B. Breteler15954693762
Lex M. Bouter158767103034
Elio Riboli1581136110499
Roy F. Baumeister157650132987
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023429
20221,014
20218,993
20208,578
20197,862
20187,020