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Institution

Utrecht University

EducationUtrecht, Utrecht, Netherlands
About: Utrecht University is a education organization based out in Utrecht, Utrecht, Netherlands. It is known for research contribution in the topics: Population & Poison control. The organization has 58176 authors who have published 139351 publications receiving 6214282 citations. The organization is also known as: UU & Universiteit Utrecht.


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Journal ArticleDOI
TL;DR: In this paper, the association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10(-24)), CYP1A2(P = 1 × 10-23), FGF5 (P=1 × 10 -21), SH2B3(P= 3 × 10−18), MTHFR(MTHFR), c10orf107(P), ZNF652(ZNF652), PLCD3 (P,P = 5 × 10 −9),
Abstract: Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N ≤ 71,225 European ancestry, N ≤ 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10(-24)), CYP1A2 (P = 1 × 10(-23)), FGF5 (P = 1 × 10(-21)), SH2B3 (P = 3 × 10(-18)), MTHFR (P = 2 × 10(-13)), c10orf107 (P = 1 × 10(-9)), ZNF652 (P = 5 × 10(-9)) and PLCD3 (P = 1 × 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.

1,205 citations

Journal ArticleDOI
John K. Colbourne1, Michael E. Pfrender2, Michael E. Pfrender3, Donald L. Gilbert1, W. Kelley Thomas4, Abraham E. Tucker1, Abraham E. Tucker4, Todd H. Oakley5, Shin-ichi Tokishita6, Andrea Aerts7, Georg J. Arnold8, Malay Kumar Basu9, Malay Kumar Basu10, Darren J Bauer4, Carla E. Cáceres11, Liran Carmel12, Liran Carmel9, Claudio Casola1, Jeong Hyeon Choi1, John C. Detter7, Qunfeng Dong13, Qunfeng Dong1, Serge Dusheyko7, Brian D. Eads1, Thomas Fröhlich8, Kerry Geiler-Samerotte14, Kerry Geiler-Samerotte5, Daniel Gerlach15, Daniel Gerlach16, Phil Hatcher4, Sanjuro Jogdeo4, Sanjuro Jogdeo17, Jeroen Krijgsveld18, Evgenia V. Kriventseva16, Dietmar Kültz19, Christian Laforsch8, Erika Lindquist7, Jacqueline Lopez1, J. Robert Manak20, J. Robert Manak21, Jean Muller22, Jasmyn Pangilinan7, Rupali P Patwardhan1, Rupali P Patwardhan23, Samuel Pitluck7, Ellen J. Pritham24, Andreas Rechtsteiner1, Andreas Rechtsteiner25, Mina Rho1, Igor B. Rogozin9, Onur Sakarya5, Onur Sakarya26, Asaf Salamov7, Sarah Schaack24, Sarah Schaack1, Harris Shapiro7, Yasuhiro Shiga6, Courtney Skalitzky20, Zachary Smith1, Alexander Souvorov9, Way Sung4, Zuojian Tang27, Zuojian Tang1, Dai Tsuchiya1, Hank Tu7, Hank Tu26, Harmjan R. Vos18, Mei Wang7, Yuri I. Wolf9, Hideo Yamagata6, Takuji Yamada, Yuzhen Ye1, Joseph R. Shaw1, Justen Andrews1, Teresa J. Crease28, Haixu Tang1, Susan Lucas7, Hugh M. Robertson11, Peer Bork, Eugene V. Koonin9, Evgeny M. Zdobnov29, Evgeny M. Zdobnov16, Igor V. Grigoriev7, Michael Lynch1, Jeffrey L. Boore30, Jeffrey L. Boore7 
04 Feb 2011-Science
TL;DR: The Daphnia genome reveals a multitude of genes and shows adaptation through gene family expansions, and the coexpansion of gene families interacting within metabolic pathways suggests that the maintenance of duplicated genes is not random.
Abstract: We describe the draft genome of the microcrustacean Daphnia pulex, which is only 200 megabases and contains at least 30,907 genes. The high gene count is a consequence of an elevated rate of gene duplication resulting in tandem gene clusters. More than a third of Daphnia's genes have no detectable homologs in any other available proteome, and the most amplified gene families are specific to the Daphnia lineage. The coexpansion of gene families interacting within metabolic pathways suggests that the maintenance of duplicated genes is not random, and the analysis of gene expression under different environmental conditions reveals that numerous paralogs acquire divergent expression patterns soon after duplication. Daphnia-specific genes, including many additional loci within sequenced regions that are otherwise devoid of annotations, are the most responsive genes to ecological challenges.

1,204 citations

Journal ArticleDOI
Dennis Dieks1
TL;DR: In this article, a recent proposal to achieve faster-than-light communication by means of an EPR-type experimental set-up is examined, and it is shown that such superluminal communication is not possible.

1,204 citations

Journal ArticleDOI
TL;DR: In this paper, a comparison of massive and mass-less theories with experiment, in particular the perihelion movement of Mercury, leads to the exclusion of the massive theory and it is concluded that the graviton mass must be rigorously zero.

1,201 citations

Journal ArticleDOI
TL;DR: In this article, the authors used meta-analytic techniques to investigate whether serious games are more effective in terms of learning and more motivating than conventional instruction methods (learning: k = 77, N 5,547; motivation:k = 31, N 2,216).
Abstract: It is assumed that serious games influences learning in 2 ways, by changing cognitive processes and by affecting motivation. However, until now research has shown little evidence for these assumptions. We used meta-analytic techniques to investigate whether serious games are more effective in terms of learning and more motivating than conventional instruction methods (learning: k = 77, N 5,547; motivation: k = 31, N 2,216). Consistent with our hypotheses, serious games were found to be more effective in terms of learning (d= 0.29, p .05) than conventional instruction methods. Additional moderator analyses on the learning effects revealed that learners in serious games learned more, relative to those taught with conventional instruction methods, when the game was supplemented with other instruction methods, when multiple training sessions were involved, and when players worked in groups.

1,199 citations


Authors

Showing all 58756 results

NameH-indexPapersCitations
Ronald C. Kessler2741332328983
Albert Hofman2672530321405
Douglas G. Altman2531001680344
Hans Clevers199793169673
Craig B. Thompson195557173172
Patrick W. Serruys1862427173210
Ruedi Aebersold182879141881
Dennis S. Charney179802122408
Kenneth S. Kendler1771327142251
Jean Louis Vincent1611667163721
Vilmundur Gudnason159837123802
Monique M.B. Breteler15954693762
Lex M. Bouter158767103034
Elio Riboli1581136110499
Roy F. Baumeister157650132987
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023429
20221,014
20218,992
20208,578
20197,862
20187,020