scispace - formally typeset
Search or ask a question
Institution

Utsunomiya University

EducationUtsunomiya, Japan
About: Utsunomiya University is a education organization based out in Utsunomiya, Japan. It is known for research contribution in the topics: Laser & Holography. The organization has 4139 authors who have published 6812 publications receiving 91975 citations. The organization is also known as: Utsunomiya daigaku.


Papers
More filters
Journal ArticleDOI
TL;DR: In this paper, three new compounds, along with four known ones, have been isolated from the seeds of Iris pallasii, based on spectroscopic methods and chemical evidence.

29 citations

Journal ArticleDOI
TL;DR: It is demonstrated that isorhamnetin has a potent anti-hyperuricemic effect and may be a potential candidate for prevention and remediation of hyperuricemia.
Abstract: Hyperuricemia is an important risk factor for gout. Isorhamnetin (3′-O-methylquercetin) is an O-methylated flavonol, which occurs in onion, almond and sea buckthorn. It is also one of the metabolites of quercetin in mammals. In the present study, we investigated anti-hyperuricemic effect of isorhamnetin adopting both cultured hepatocytes and mice with hyperuricemia induced by purine bodies. In cultured hepatocytes, isorhamnetin as well as quercetin significantly and dose-dependently inhibited uric acid (UA) production. We also examined the inhibitory effects on UA production of other mono-methylquercetins, i.e., tamarixetin, 3-O-methylquercetin, azaleatin, and rhamnetin in addition to isorhamnetin for studying their structure–activity relationships. From the results obtained, hydroxyl groups at C-3, C-5, and especially C-7, but not C-3′ and C-4′ of quercetin are demonstrated to play a critical role in suppressing UA production in the AML12 hepatocytes. Oral administration of isorhamnetin significantly reduced plasma and hepatic UA levels in the hyperuricemic model mice. Isorhamnetin also decreased hepatic xanthine oxidase (XO) activity without changes in XO protein expression, indicating that anti-hyperuricemic effect of isorhamnetin could be, at least partly, attributable to suppression of UA production by directly inhibiting XO activity in the liver. These findings demonstrate that isorhamnetin has a potent anti-hyperuricemic effect and may be a potential candidate for prevention and remediation of hyperuricemia.

29 citations

Journal ArticleDOI
TL;DR: In this article, an alternating magnetic field was used to control the force and dynamic motion of the tools needed for machining, and the relationship between the magnetic field, the tool properties and the tool behavior was analyzed.
Abstract: Imparting compressive residual stress to a surface improves the fatigue structural integrity of components, which is particularly important for components used in such critical applications as high-pressure gas or liquid piping systems. This paper proposes a new precision internal machining process that controls the surface integrity of internal surface of these components. This process utilizes an alternating magnetic field to control the force and dynamic motion of the tools needed for machining. An experimental set-up was developed to test the processing principle. This study characterizes the in-process tool behavior—that is, the relationships between the magnetic field, the tool properties, and the tool behavior—and reveals the properties of the tools required to achieve the desired results: magnetic anisotropy and a specific geometric restriction. The surface roughness, hardness, and residual stress measurements following machining experiments demonstrate the effects of the tool behavior on the machining characteristics. This paper also proposes methods to obtain desired surface characteristics.

29 citations

Journal ArticleDOI
TL;DR: A RING-type E3 ubiquitin ligase is discovered, which selectively ubiquitinates the empty form of Drosophila Ago1 to trigger its degradation and reveals a sophisticated mechanism for the selective degradation of empty AGO that underlies a quality control process to ensure AGO function.

29 citations

Journal ArticleDOI
TL;DR: In this article, a study of 1.66 GeV c K − beam induced (K −,K + ) reactions in the nuclear emulsion target is presented and 796 ( K −, K + ) reaction vertices ( p K + ⩾ 1 GeV /c ) containing 18 single hyperfragments are identified.

28 citations


Authors

Showing all 4148 results

NameH-indexPapersCitations
Kazuhito Hashimoto12078161195
Yoshinori Yamamoto8595028130
S. Uehara7860223493
Minghua Liu7467920727
Akira Fujishima7029969335
Satoshi Hasegawa6970822153
Donald A. Tryk6724025469
Hiromu Suzuki6525015241
Kunio Arai6429315022
Kazuo Suzuki6350717786
Jin Wang6019610435
James B. Reid6024611773
Richard L. Smith5930211420
Isao Kubo5830311291
Takao Yokota5724511813
Network Information
Related Institutions (5)
Tokyo Institute of Technology
101.6K papers, 2.3M citations

93% related

University of Tokyo
337.5K papers, 10.1M citations

92% related

University of Tsukuba
79.4K papers, 1.9M citations

92% related

Nagoya University
128.2K papers, 3.2M citations

91% related

Kyoto University
217.2K papers, 6.5M citations

91% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20236
202231
2021247
2020315
2019315
2018289