Institution
VA Boston Healthcare System
Healthcare•Boston, Massachusetts, United States•
About: VA Boston Healthcare System is a healthcare organization based out in Boston, Massachusetts, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 2541 authors who have published 4860 publications receiving 181094 citations. The organization is also known as: VA Medical Center & VA Hospital.
Topics: Population, Poison control, Veterans Affairs, Health care, Mental health
Papers published on a yearly basis
Papers
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Gregory A. Roth1, Gregory A. Roth2, Degu Abate3, Kalkidan Hassen Abate4 +1025 more•Institutions (333)
TL;DR: Non-communicable diseases comprised the greatest fraction of deaths, contributing to 73·4% (95% uncertainty interval [UI] 72·5–74·1) of total deaths in 2017, while communicable, maternal, neonatal, and nutritional causes accounted for 18·6% (17·9–19·6), and injuries 8·0% (7·7–8·2).
5,211 citations
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) as discussed by the authors was used to estimate the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015.
5,050 citations
TL;DR: The Global Burden of Disease 2015 Study provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015, finding several countries in sub-Saharan Africa had very large gains in life expectancy, rebounding from an era of exceedingly high loss of life due to HIV/AIDS.
4,804 citations
TL;DR: This study suggests that autophagic proteins regulate NALP3-dependent inflammation by preserving mitochondria integrity and cytosolic translocation of mitochondrial DNA in response to lipopolysaccharide and ATP in macrophages.
Abstract: Autophagy, a cellular process for organelle and protein turnover, regulates innate immune responses. Here we demonstrate that depletion of the autophagic proteins LC3B and beclin 1 enhanced the activation of caspase-1 and secretion of interleukin 1β (IL-1β) and IL-18. Depletion of autophagic proteins promoted the accumulation of dysfunctional mitochondria and cytosolic translocation of mitochondrial DNA (mtDNA) in response to lipopolysaccharide (LPS) and ATP in macrophages. Release of mtDNA into the cytosol depended on the NALP3 inflammasome and mitochondrial reactive oxygen species (ROS). Cytosolic mtDNA contributed to the secretion of IL-1β and IL-18 in response to LPS and ATP. LC3B-deficient mice produced more caspase-1-dependent cytokines in two sepsis models and were susceptible to LPS-induced mortality. Our study suggests that autophagic proteins regulate NALP3-dependent inflammation by preserving mitochondrial integrity.
2,352 citations
University of Arizona1, Ludwig Maximilian University of Munich2, Technische Universität München3, Hospital Universitario La Paz4, Katholieke Universiteit Leuven5, Hebrew University of Jerusalem6, Innsbruck Medical University7, Poznan University of Medical Sciences8, Stanford University9, Oslo University Hospital10, University of Oslo11, BC Cancer Agency12, University of Texas MD Anderson Cancer Center13, Linköping University14, McGill University15, Cedars-Sinai Medical Center16, Harvard University17, VA Boston Healthcare System18
TL;DR: Among patients with platinum-sensitive, recurrent ovarian cancer, the median duration of progression-free survival was significantly longer amongThose receiving niraparib than among those receiving placebo, regardless of the presence or absence of gBRCA mutations or HRD status, with moderate bone marrow toxicity.
Abstract: Tesaro; Amgen; Genentech; Roche; AstraZeneca; Myriad Genetics; Merck; Gradalis; Cerulean; Vermillion; ImmunoGen; Pfizer; Bayer; Nu-Cana BioMed; INSYS Therapeutics; GlaxoSmithKline; Verastem; Mateon Therapeutics; Pharmaceutical Product Development; Clovis Oncology; Janssen/Johnson Johnson; Eli Lilly; Merck Sharp Dohme
1,686 citations
Authors
Showing all 2573 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Ralph B. D'Agostino | 226 | 1287 | 229636 |
| Christopher J. O'Donnell | 159 | 869 | 126278 |
| Deepak L. Bhatt | 149 | 1973 | 114652 |
| David P. Strachan | 143 | 472 | 105256 |
| Susan Redline | 138 | 899 | 80945 |
| Ramnik J. Xavier | 138 | 597 | 101879 |
| Nikhil C. Munshi | 134 | 906 | 67349 |
| Steven R. Simon | 129 | 1090 | 80331 |
| Richard D. Gelber | 127 | 467 | 81399 |
| Larry J. Seidman | 127 | 637 | 65760 |
| Christos S. Mantzoros | 124 | 712 | 55587 |
| Robert W. McCarley | 120 | 584 | 61051 |
| Ian H. Gotlib | 118 | 517 | 52833 |
| William G. Henderson | 115 | 439 | 53071 |
| J. Michael Gaziano | 115 | 579 | 52562 |