Institution
Vanderbilt University
Education•Nashville, Tennessee, United States•
About: Vanderbilt University is a education organization based out in Nashville, Tennessee, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 45066 authors who have published 106528 publications receiving 5435039 citations. The organization is also known as: Vandy.
Topics: Population, Cancer, Receptor, Health care, Poison control
Papers published on a yearly basis
Papers
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TL;DR: Data indicate that defective DC function in cancer patients is the result of decreased numbers of competent DCs and the accumulation of immature cells, which may have significant clinical implications.
Abstract: Defective
dendritic cell (DC) function has been described previously in cancer
patients and tumor-bearing mice. It can be an important factor in the
escape of tumors from immune system control. However, the mechanism and
clinical significance of this phenomenon remain unclear. Here, 93
patients with breast, head and neck, and lung cancer were investigated.
The function of peripheral blood and tumor draining lymph node DCs was
equally impaired in cancer patients, consistent with a systemic rather
than a local effect of tumor on DCs. The number of DCs was dramatically
reduced in the peripheral blood of cancer patients. This decrease was
associated with the accumulation of cells lacking markers of mature
hematopoietic cells. The presence of these immature cells was closely
associated with the stage and duration of the disease. Surgical removal
of tumor resulted in partial reversal of the observed effects. The
presence of immature cells in the peripheral blood of cancer patients
was closely associated with an increased plasma level of vascular
endothelial growth factor but not interleukin 6, granulocyte
macrophage colony-stimulating factor, macrophage colony-stimulating
factor, interleukin 10, or transforming growth factor-β and was
decreased in lung cancer patients receiving therapy with antivascular
endothelial growth factor antibodies. These data indicate that
defective DC function in cancer patients is the result of decreased
numbers of competent DCs and the accumulation of immature cells. This
effect may have significant clinical implications.
726 citations
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TL;DR: The data reveal a core function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120.
Abstract: p120-catenin stabilizes epithelial cadherin (E-cadherin) in SW48 cells, but the mechanism has not been established. Here, we show that p120 acts at the cell surface to control cadherin turnover, thereby regulating cadherin levels. p120 knockdown by siRNA expression resulted in dose-dependent elimination of epithelial, placental, neuronal, and vascular endothelial cadherins, and complete loss of cell–cell adhesion. ARVCF and δ-catenin were functionally redundant, suggesting that proper cadherin-dependent adhesion requires the presence of at least one p120 family member. The data reveal a core function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120.
726 citations
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TL;DR: The results of studies directed toward determining the time course and likely mechanisms underlying this remarkable plasticity of the cortex representing the skin of the median nerve within parietal somatosensory fields 3b and 1 are described.
725 citations
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TL;DR: Empirical, clinical, and autopsy studies have been used to examine PCa overdiagnosis, with estimates ranging widely from 1.7% to 67%.
724 citations
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TL;DR: The authors found that parents' involvement activities take many forms, from establishing structures for homework performance to teaching for understanding and developing student learning strategies, operating largely through modeling, reinforcement, and instruction.
Abstract: The article reviews research on parental involvement in student homework. It is focused on understanding: why parents become involved in their children's homework; which activities and strategies they employ in the course of involvement; how their homework involvement influences student outcomes; and which student outcomes are influenced by parents' involvement. Findings suggest that parents involve themselves in student homework because they believe that they should be involved, believe that their involvement will make a positive difference, and perceive that their children or children's teachers want their involvement. Parents' involvement activities take many forms, from establishing structures for homework performance to teaching for understanding and developing student learning strategies. Operating largely through modeling, reinforcement, and instruction, parents' homework involvement appears to influence student success insofar as it supports student attributes related to achievement (e.g., attitud...
724 citations
Authors
Showing all 45403 results
Name | H-index | Papers | Citations |
---|---|---|---|
Walter C. Willett | 334 | 2399 | 413322 |
Meir J. Stampfer | 277 | 1414 | 283776 |
John Q. Trojanowski | 226 | 1467 | 213948 |
Robert M. Califf | 196 | 1561 | 167961 |
Matthew Meyerson | 194 | 553 | 243726 |
Scott M. Grundy | 187 | 841 | 231821 |
Tony Hunter | 175 | 593 | 124726 |
David R. Jacobs | 165 | 1262 | 113892 |
Donald E. Ingber | 164 | 610 | 100682 |
L. Joseph Melton | 161 | 531 | 97861 |
Ralph A. DeFronzo | 160 | 759 | 132993 |
David W. Bates | 159 | 1239 | 116698 |
Charles N. Serhan | 158 | 728 | 84810 |
David Cella | 156 | 1258 | 106402 |
Jay Hauser | 155 | 2145 | 132683 |