Vanderbilt University

About: Vanderbilt University is a education organization based out in Nashville, Tennessee, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 45066 authors who have published 106528 publications receiving 5435039 citations. The organization is also known as: Vandy.

Basic mechanisms and modeling of single-event upset in digital microelectronics

Abstract: Physical mechanisms responsible for nondestructive single-event effects in digital microelectronics are reviewed, concentrating on silicon MOS devices and integrated circuits. A brief historical overview of single-event effects in space and terrestrial systems is given, and upset mechanisms in dynamic random access memories, static random access memories, and combinational logic are detailed. Techniques for mitigating single-event upset are described, as well as methods for predicting device and circuit single-event response using computer simulations. The impact of technology trends on single-event susceptibility and future areas of concern are explored.

Issues and recommendations regarding use of the Beck Depression Inventory

Abstract: Issues concerning use of the Beck Depression Inventory (BDI) for the self-report of depressive symptomatology are raised and considered. Discussion includes the stability of depression and the need for multiple assessment periods, specificity and the need for multiple assessment measures, and selection cut scores and the need for terminological accuracy. Recommendations for the continued use of the BDI, designed to facilitate the integration of diverse studies and improve research on self-reported depression, are provided.

Immunologic characterization of human malignant lymphomas

Abstract: The immunologic and morphological approach of our recently proposed functional classification of malignant lymphomas based on the T and B cell systems and lymphocyte transformation has been reviewed. Preliminary results of our retrospective morphological studies indicate: 1) Over 70% of non-Hodgkin's lymphomas involve cleaved or noncleaved follicular center cell (FCC) or B cell types. 2) Nodularity is observed only with FCC types and suggest origin in follicular centers as a block or a “switch on” (derepression) in B cell lymphocyte transformation. 3) Lymphomas of “true” histiocytes appear rare and need to be redefined with functional studies since those previously regarded as histiocytic are indistinguishable morphologically from transformed lymphocytes. 4) Lymphomas of large transformed lymphocytes, “immunoblastic sarcoma” of B and T cell types, have been observed to develop in abnormal immune states and senescence and represent a distinctive entity. Ideal characterization of lymphomas using integrated morphological, cytochemical, and immunologic membrane marker studies has been outlined, and preliminary results of this approach provide support for our new proposal.