Institution
Veterans Health Administration
Government•Washington D.C., District of Columbia, United States•
About: Veterans Health Administration is a government organization based out in Washington D.C., District of Columbia, United States. It is known for research contribution in the topics: Population & Veterans Affairs. The organization has 63820 authors who have published 98417 publications receiving 4835425 citations. The organization is also known as: VHA.
Papers published on a yearly basis
Papers
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TL;DR: The classic paradigms of wound healing are reviewed and how recent discoveries have enriched understanding of this process are evaluated, with an emphasis on cell-based therapies and skin transplantation.
Abstract: The ability of the skin to repair itself after injury is vital to human survival and is disrupted in a spectrum of disorders. The process of cutaneous wound healing is complex, requiring a coordinated response by immune cells, hematopoietic cells, and resident cells of the skin. We review the classic paradigms of wound healing and evaluate how recent discoveries have enriched our understanding of this process. We evaluate current and experimental approaches to treating cutaneous wounds, with an emphasis on cell-based therapies and skin transplantation.
528 citations
TL;DR: Five major DNA repair pathways are homologous recombinational repair (HRR), non-homologous end joining (NHEJ), nucleotide excision repair (NER), base excision Repair (BER) and mismatch repair (MMR), and key proteins occur with dual functions in DNA damage sensing/repair and apoptosis.
Abstract: Two systems are essential in humans for genome integrity, DNA repair and apoptosis. Cells that are defective in DNA repair tend to accumulate excess DNA damage. Cells defective in apoptosis tend to survive with excess DNA damage and thus allow DNA replication past DNA damages, causing mutations leading to carcinogenesis. It has recently become apparent that key proteins which contribute to cellular survival by acting in DNA repair become executioners in the face of excess DNA damage. Five major DNA repair pathways are homologous recombinational repair (HRR), non-homologous end joining (NHEJ), nucleotide excision repair (NER), base excision repair (BER) and mismatch repair (MMR). In each of these DNA repair pathways, key proteins occur with dual functions in DNA damage sensing/repair and apoptosis. Proteins with these dual roles occur in: (1) HRR (BRCA1, ATM, ATR, WRN, BLM, Tip60 and p53); (2) NHEJ (the catalytic subunit of DNA-PK); (3) NER (XPB, XPD, p53 and p33 ING1b ); (4) BER (Ref-1/Ape, poly(ADP-ribose) polymerase-1 (PARP-1) and p53); (5) MMR (MSH2, MSH6, MLH1 and PMS2). For a number of these dual-role proteins, germ line mutations causing them to be defective also predispose individuals to cancer. Such proteins include BRCA1, ATM, WRN, BLM, p53, XPB, XPD, MSH2, MSH6, MLH1 and PMS2. © 2002 Elsevier Science B.V. All rights reserved.
528 citations
Veterans Health Administration1, University of Minnesota2, University of Washington3, Duke University4, Roswell Park Cancer Institute5, Harvard University6, University of Barcelona7, National Institutes of Health8, Center for International Blood and Marrow Transplant Research9, Medical College of Wisconsin10, Cleveland Clinic11, Ottawa Hospital Research Institute12, Joseph Fourier University13, Columbia University14, Princess Margaret Cancer Centre15, Mayo Clinic16
TL;DR: Conditioning intensity, TBI and graft source have a combined effect on risk of AGVHD that must be considered in deciding on a treatment strategy for individual patients.
528 citations
Shandong University1, Stanford University2, Osaka City University3, Sun Yat-sen University4, Xi'an Jiaotong University5, Kyushu University6, Shanghai University7, Harbin Medical University8, Saga Group9, Fu Jen Catholic University10, Chung Shan Medical University11, Hanyang University12, The Chinese University of Hong Kong13, Veterans Health Administration14
TL;DR: NAFLD prevalence in Asia is increasing and is associated with poor outcomes including hepatocellular carcinoma and death, especially in high-risk groups, such as older obese men, and targeted public health strategies must be developed in Asia.
527 citations
TL;DR: To update evidence‐based medicine recommendations for treating nonmotor symptoms in Parkinson's disease, the World Health Organization (WHO) selected Austria as a preferred destination for research and clinical trials.
Abstract: Objective
To update evidence‐based medicine recommendations for treating nonmotor symptoms in Parkinson's disease (PD).
527 citations
Authors
Showing all 63886 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Michael Karin | 236 | 704 | 226485 |
| Paul M. Ridker | 233 | 1242 | 245097 |
| Eugene Braunwald | 230 | 1711 | 264576 |
| Ralph B. D'Agostino | 226 | 1287 | 229636 |
| John Q. Trojanowski | 226 | 1467 | 213948 |
| Fred H. Gage | 216 | 967 | 185732 |
| Edward Giovannucci | 206 | 1671 | 179875 |
| Rob Knight | 201 | 1061 | 253207 |
| Frank E. Speizer | 193 | 636 | 135891 |
| Stephen V. Faraone | 188 | 1427 | 140298 |
| Scott M. Grundy | 187 | 841 | 231821 |
| Paul G. Richardson | 183 | 1533 | 155912 |
| Peter W.F. Wilson | 181 | 680 | 139852 |
| Dennis S. Charney | 179 | 802 | 122408 |
| Kenneth C. Anderson | 178 | 1138 | 126072 |