scispace - formally typeset
Search or ask a question
Institution

Victor Chang Cardiac Research Institute

NonprofitSydney, New South Wales, Australia
About: Victor Chang Cardiac Research Institute is a nonprofit organization based out in Sydney, New South Wales, Australia. It is known for research contribution in the topics: Mechanosensitive channels & Transplantation. The organization has 708 authors who have published 1599 publications receiving 70035 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: This Review surveys the achievements and potential of zebrafish for modelling human diseases and for drug discovery and development.
Abstract: Despite the pre-eminence of the mouse in modelling human disease, several aspects of murine biology limit its routine use in large-scale genetic and therapeutic screening. Many researchers who are interested in an embryologically and genetically tractable disease model have now turned to zebrafish. Zebrafish biology allows ready access to all developmental stages, and the optical clarity of embryos and larvae allow real-time imaging of developing pathologies. Sophisticated mutagenesis and screening strategies on a large scale, and with an economy that is not possible in other vertebrate systems, have generated zebrafish models of a wide variety of human diseases. This Review surveys the achievements and potential of zebrafish for modelling human diseases and for drug discovery and development.

1,998 citations

Journal ArticleDOI
08 Jun 2012-Cell
TL;DR: Unexpectedly, it is found that many proteins of the HeLa mRNA interactome are highly intrinsically disordered and enriched in short repetitive amino acid motifs.

1,782 citations

Journal ArticleDOI
TL;DR: The results of a genomewide scan of schizophrenia families in Iceland show that schizophrenia maps to chromosome 8p, and extensive fine-mapping of the 8p locus and haplotype-association analysis identifies neuregulin 1 (NRG1) as a candidate gene for schizophrenia.
Abstract: The cause of schizophrenia is unknown, but it has a significant genetic component. Pharmacologic studies, studies of gene expression in man, and studies of mouse mutants suggest involvement of glutamate and dopamine neurotransmitter systems. However, so far, strong association has not been found between schizophrenia and variants of the genes encoding components of these systems. Here, we report the results of a genomewide scan of schizophrenia families in Iceland; these results support previous work, done in five populations, showing that schizophrenia maps to chromosome 8p. Extensive fine-mapping of the 8p locus and haplotype-association analysis, supplemented by a transmission/disequilibrium test, identifies neuregulin 1 (NRG1) as a candidate gene for schizophrenia. NRG1 is expressed at central nervous system synapses and has a clear role in the expression and activation of neurotransmitter receptors, including glutamate receptors. Mutant mice heterozygous for either NRG1 or its receptor, ErbB4, show a behavioral phenotype that overlaps with mouse models for schizophrenia. Furthermore, NRG1 hypomorphs have fewer functional NMDA receptors than wild-type mice. We also demonstrate that the behavioral phenotypes of the NRG1 hypomorphs are partially reversible with clozapine, an atypical antipsychotic drug used to treat schizophrenia.

1,650 citations

Journal ArticleDOI
TL;DR: Having knowledge of transglutaminases is essential for understanding the aetiologies of diverse hereditary diseases of the blood and skin, and various autoimmune, inflammatory and degenerative conditions.
Abstract: Blood coagulation, skin-barrier formation, hardening of the fertilization envelope, extracellular-matrix assembly and other important biological processes are dependent on the rapid generation of covalent crosslinks between proteins. These reactions--which are catalysed by transglutaminases--endow the resulting supramolecular structure with extra rigidity and resistance against proteolytic degradation. Some transglutaminases function as molecular switches in cytoskeletal scaffolding and modulate protein-protein interactions. Having knowledge of these enzymes is essential for understanding the aetiologies of diverse hereditary diseases of the blood and skin, and various autoimmune, inflammatory and degenerative conditions.

1,385 citations

Journal ArticleDOI
TL;DR: Central haemodynamic indexes are independent predictors of future CV events and all-cause mortality andAugmentation index predicts clinical events independently of peripheral pressures, while central PP has a marginally but not significantly better predictive ability when compared with peripheral PP.
Abstract: We meta-analysed 11 longitudinal studies that had employed measures of central haemodynamics and had followed 5648 subjects for a mean follow-up of 45 months. The age- and risk-factor-adjusted pooled relative risk (RR) of total CV events was 1.088 (95% CI 1.040-1.139) for a 10 mmHg increase of central systolic pressure, 1.137 (95% CI 1.063-1.215) for a 10 mmHg increase of central pulse pressure (PP), and 1.318 (95% CI 1.093-1.588) for a 10% absolute increase of central augmentation index (AIx). Furthermore, we found that a 10% increase of central AIx was associated with a RR of 1.384 (95% CI 1.192-1.606) for all-cause mortality. When compared with brachial PP, central PP was associated with marginally but not significantly higher RR of clinical events (P ¼ 0.057). Conclusion Central haemodynamic indexes are independent predictors of future CV events and all-cause mortality. Augmenta- tion index predicts clinical events independently of peripheral pressures, while central PP has a marginally but not significantly (P ¼ 0.057) better predictive ability when compared with peripheral PP.

1,223 citations


Authors

Showing all 728 results

NameH-indexPapersCitations
Bruce D. Walker15577986020
Stefanie Dimmeler14757481658
Matthias W. Hentze11031941879
Roland Stocker9233134364
Richard P. Harvey8340327060
Michael F. O'Rourke8145135355
Robert Terkeltaub8028421034
Robert M. Graham6931916342
Sunil Gupta6944033856
Anne Keogh6433720268
Filip K. Knop6143713614
Peter S. Macdonald5745512988
Boris Martinac5624514121
Carolyn L. Geczy551878987
Christopher J. Ormandy541318757
Network Information
Related Institutions (5)
Scripps Research Institute
32.8K papers, 2.9M citations

87% related

National Institutes of Health
297.8K papers, 21.3M citations

87% related

University of Texas Southwestern Medical Center
75.2K papers, 4.4M citations

87% related

Baylor College of Medicine
94.8K papers, 5M citations

87% related

Albert Einstein College of Medicine
56.4K papers, 2.7M citations

86% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20234
202220
2021157
2020141
2019122
201897