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Showing papers by "Vignan University published in 2015"


Journal ArticleDOI
TL;DR: In this article, the powder is annealed at three different temperatures (400 o C, 500 o C and 1000 o C) for one hour and X-ray diffraction patterns confirm the spinel structure of the samples.

91 citations


Proceedings ArticleDOI
01 Dec 2015
TL;DR: This paper presents Abhaya, an Android Application for the Safety of Women, to send the message to the registered contacts continuously for every five minutes until the “stop” button in the application is clicked.
Abstract: In today's world, people using smart phones have increased rapidly and hence, a smart phone can be used efficiently for personal security or various other protection purposes. The heinous incident that outraged the entire nation have waken us to go for the safety issues and so a host of new apps have been developed to provide security systems to women via their phones. This paper presents Abhaya, an Android Application for the Safety of Women and this app can be activated this app by a single click, whenever need arises. A single click on this app identifies the location of place through GPS and sends a message comprising this location URL to the registered contacts and also call on the first registered contact to help the one in dangerous situations. The unique feature of this application is to send the message to the registered contacts continuously for every five minutes until the “stop” button in the application is clicked. Continuous location tracking information via SMS helps to find the location of the victim quickly and can be rescued safely.

74 citations


Proceedings ArticleDOI
19 Mar 2015
TL;DR: The health care scheme is focus on the measurement and Monitoring various biological parameters of patient's body like heart rate, oxygen saturation level in blood and temperature using a web server and android application, where doctor can continuously monitor the patient's condition on his smart phone using an Android application.
Abstract: Generally in critical case patients are supposed to be monitored continuously for their SP0 2 , Heart Rate as well as temperature. In the earlier methods, the doctors need to be present physically or in several cases SMS will be sent using GSM. In the earlier case the history of the patient cannot be displayed, only current data is displayed. In the current paper, we are using a novel idea for continuous monitoring patient's health conditions. The health care scheme is focus on the measurement and Monitoring various biological parameters of patient's body like heart rate, oxygen saturation level in blood and temperature using a web server and android application, where doctor can continuously monitor the patient's condition on his smart phone using an Android application. And also the patient history will be stored on the web server and doctor can access the information whenever needed from anywhere and need not physically present.

46 citations


Journal ArticleDOI
TL;DR: In this paper, a co-sputtering of dual InGaZnO and ZnO targets is used to fabricate a high performance indium gallium zinc oxide (IGZO) thin film transistor.
Abstract: A co-sputtering of dual InGaZnO and ZnO targets, abbreviated by ZnO co-sputtered IGZO, is used to fabricate a high performance indium gallium zinc oxide (IGZO) thin film transistor in this work. The ZnO co-sputtered IGZO thin film exhibits a smooth (Rrms ∼ 0.29 nm), featureless, and amorphous structure with high carrier density (n ∼4.29 × 1017 cm−3). The performance and stability of ZnO co-sputtered IGZO TFT has been investigated and compared with the counterparts fabricated by a single ZnO and a-IGZO target respectively. Highest linear field effect mobility of 16.1 cm2 V−1 s−1 with an Ion/Ioff ratio of 1.04 × 107, saturation drain current of 3.8 μA at 5 V, and the lowest threshold voltage of 2.0 V with sub-threshold swing of 0.21 V per decade have been obtained for the ZnO co-sputtered IGZO TFT. Furthermore, the ZnO co-sputtered IGZO TFT exhibited only a threshold voltage shift (ΔVth) of 2.75 V under negative biased illuminated stress conditions for 2500 s, whereas the IGZO and ZnO based TFTs suffered from a huge threshold voltage shift (ΔVth > 6 V) under the same conditions. The obtained performance and stability of TFTs with ZnO co-sputtered IGZO film is very promising for low voltage display applications.

21 citations


Journal ArticleDOI
TL;DR: In this article, the authors studied the development in information and technology enable banks in value added services to be effective in satisfying customer needs by adopting new innovative solutions in banking services to meet perceived value and expectations.
Abstract: Background/Objectives: This paper studies the development in information and technology enable banks in value added services to be effective in satisfying customer needs by adopting new innovative solutions in banking services to meet perceived value and expectations. Methods/Statistical Analysis: To study the perceptions of bank customers, bank employees regarding the use of various products/services delivery channels and their acceptability in Andhra Pradesh. 200 sample respondents had interviewed in order to assess the number of existing bank customers availing e-banking services. Correlation analysis also applied in this study. Findings: Regardless of their size, profitability and growth demand that banks focus on serving customers at the right time, with the right level of service and at the right cost. Several factors are driving this customer focus. Number one, today’s customers expect personalized pricing and portfolio mixes. Banks that can’t deliver will suffer reduced profitability. While banks, by default, sell every product to every customer, digital banking allows customization, providing the data and analytics capabilities needed to examine each customer’s profitability and offer individual¬ized or segmented products and pricing. Application/Improvements: To stay profitable and grow in the new digital economy, banks need to adopt a customer-centric business model, diversify online delivery of products and services channels, and begin making meaning from valuable trails of digital information.

17 citations


Journal ArticleDOI
01 May 2015
TL;DR: In modern manufacturing system, tool condition is one of the important factors which affects the machining under various cutting conditions, and the tool has to be replaced when it was worn out as discussed by the authors.
Abstract: In modern manufacturing system, tool condition is one of the important factors which affects the machining under various cutting conditions, and the tool has to be replaced when it was worn out. Th...

17 citations


Proceedings ArticleDOI
02 Apr 2015
TL;DR: A new current-mode electronically-tunable Schmitt trigger circuit is proposed using Differential Difference Current Conveyor Transconductance amplifier (DDCCTA), consisting of single DDCCTA block without any passive components which is advantageous from the point of view of an integrated circuit manufacturing.
Abstract: Among various active building blocks, the Differential Difference Current Conveying Transconductance Amplifier (DDCCTA) is emerging as a very flexible and versatile building blocks for analog circuit design and has been used for realizing a variety of functions. In this paper, a new current-mode electronically-tunable Schmitt trigger circuit is proposed using Differential Difference Current Conveyor Transconductance amplifier (DDCCTA). The proposed Schmitt trigger consists of single DDCCTA block without any passive components which is advantageous from the point of view of an integrated circuit manufacturing. The performance of the proposed Schmitt trigger circuit is examined using Cadence and the model parameters of a 0.18 µm CMOS process.

14 citations


Journal ArticleDOI
TL;DR: In this article, a series of BiFeO3 ceramics were synthesized by sol-gel method and characterized by X-ray diffractometer (XRD), vibrating sample magnetometer (VSM) and dielectric measurement.
Abstract: A series of Bi1-x La x Fe0.98Cu0.02O3 (x = 0.01, 0.03 and 0.05) ceramics were synthesized by sol–gel method. The prepared ceramics were characterized by X-ray diffractometer (XRD), vibrating sample magnetometer (VSM) and dielectric measurement. XRD patterns reveal that Bi1-x La x Fe0.98Cu0.02O3 (x = 0.01, 0.03 and 0.05) ceramics crystallize in single-phase rhombohedral structure with R3c space group without distortion, and the average crystallite size was in the range of 31–92 nm. VSM exhibited a weak ferromagnetism for La- and Cu-co-doped BiFeO3 ceramics. The squareness ratio of the hysteresis loop decreases as La concentration increases in Bi1-x La x Fe0.98Cu0.02O3. However, these materials show improved dielectric properties compared to undoped BiFeO3 ceramic.

13 citations


Proceedings ArticleDOI
01 Nov 2015
TL;DR: In this paper, the authors presented a new MPPT controller with variable irradiance and variable temperature unlike the existing MPPT controllers where either constant irradiance or constant temperature are considered as parameters.
Abstract: Solar energy is an important alternative out of the various renewable energy sources This paper presents a new modeling of Maximum power point tracking controller with variable irradiance and variable temperature unlike the existed MPPT controller methods where either constant irradiance or constant temperature are considered as parameters Using this proposed MPPT controller the parameters such as Power, voltage and current are analyzed using simulation model and experimental validation This output obtained from the MPPT controller is given to DC-DC boost converter and inverter in order to enhance the output power obtained from the PV array system The results obtained using the proposed controller is compared with the existed perturb and observe methods

12 citations


Proceedings ArticleDOI
26 Mar 2015
TL;DR: This paper illustrates two sinusoidal oscillators based on single Operational Transresistance Amplifier (OTRA) that demonstrate excellent agreement with theoretical values.
Abstract: This paper illustrates two sinusoidal oscillators based on single Operational Transresistance Amplifier (OTRA). The proposed circuits require a single OTRA and a few passive components to generate the oscillations. The proposed circuit's frequency of oscillation and condition of oscillation are given. The proposed circuits have been examined using Cadence 180 nm CMOS model parameters. These circuits have been constructed using commercially available current feedback amplifier (AD844 AN) and later on passive components were connected externally and tested for waveform generation. The results obtained demonstrate excellent agreement with theoretical values.

11 citations


Proceedings ArticleDOI
26 Mar 2015
TL;DR: In this article, a current mode Schmitt trigger using CDTA is presented, which employs only a single CDTA, without any passive component, that has been suitable for implementation of the IC design.
Abstract: A current mode Schmitt trigger using Current Differencing Transconductance Amplifier (CDTA) is presented in this paper The proposed circuit employs only a single CDTA, without any passive component, that has been suitable for implementation of the IC design The operation of the proposed Schmitt trigger circuit has been observed and enforced at a supply voltage ± 085 V (bias current 32 µA) using Cadence and the model parameters of a gpdk 180 nm CMOS technology The Schmitt trigger circuit in this paper, which is realized using CDTA provides impervious to noise and insensitive to temperature

Journal ArticleDOI
TL;DR: The proximate composition on the S. simplex indicates that they are rich in protein, lipids, essential amino acids and fatty acids, and availability of these growth factors was perfectly reflected on the successful growth rate of C. auratus.
Abstract: A feed trail was conducted to evaluate the efficiency of Streptocephalus simplex as a live feed in freshwater ornamental fish culture. The efficiency of live feed was compared with that of artificial/pellet diet to determine the growth rate biochemical parameters and carotenoid concentration of Carassius auratus for a period of 45 days. As a result the proximate composition on the S. simplex indicates that they are rich in protein, lipids, essential amino acids and fatty acids. Availability of these growth factors was perfectly reflected on the successful growth rate of C. auratus. Moreover, presence of carotenoids viz., astaxanthin (36.4 ± 2.4), canthaxanthin (23.6 ± 1.7), and β-carotene (1.7 ± 0.6) has improved the intensity of the skin color of commercially important ornamental fish C. auratus after feeding with S. simplex.

Journal ArticleDOI
TL;DR: In this article, the authors discuss some topological properties and generalizations of dislocated metric space and establish some fixed point theorems, and discuss the relation between these properties and the fixed point theorem.
Abstract: In this note we discuss some topological properties and generalizations of dislocated metric space and establish some fixed point theorems. Mathematics Subject Classification: 47H10, 54H25.

Proceedings ArticleDOI
02 Apr 2015
TL;DR: Low voltage, high speed 1-bit full adder cells in Branch Based Logic and Pass Transistor (BBL-PT) logic are presented by using FinFET model parameters using Cadence and model parameters of 180 nm CMOS technology.
Abstract: Feature size of CMOS technology continues to scale down; new devices like FinFET are experimented and proposed as an alternative device due to its superior characteristics. In this paper we have presented low voltage, high speed 1-bit full adder cells in Branch Based Logic and Pass Transistor (BBL-PT) logic by using FinFET model parameters. In BBL-PT full adder lies a drawback i.e. voltage step existed in sum output. That could be eliminated in the proposed logics by using the diode connected FinFET (D-FinFET) inverter, N-type FinFET inverter and modified current sink restorer structures. Proposed full adder circuits are compared with conventional adder circuits, and proposed circuits have demonstrated the good delay performance. The performance of proposed and other conventional full adder circuits are examined using Cadence and the model parameters of 180 nm CMOS technology with +1.2 V supply rail voltage and 20 nm FinFET model files with +0.6 V supply rail voltage with frequency 100 MHz.

Proceedings ArticleDOI
01 Dec 2015
TL;DR: This paper elucidates an Energy Efficient Cluster Based Routing Protocol (EECBRP) for wireless sensor networks, used to pile up data from scattered sensor nodes and transmit the same to a base station, which ensures 20% more life time than LEACH protocol.
Abstract: This paper elucidates an Energy Efficient Cluster Based Routing Protocol (EECBRP) for wireless sensor networks. It accomplishes ameliorate performance by means of network lifetime and energy efficiency. It is used to pile up data from scattered sensor nodes and transmit the same to a base station. EEBCRP is designed to shore up the remote monitoring in sensor networks, periodically. Major issues here are, cluster head (CH) selection, forming cluster scheme and a routing algorithm for the data transmission between cluster heads and the base station. The cluster formation is carried out by exchanging messages between member nodes and the cluster head. The key function of the cluster head is rotated at predefined interval to assure even distribution of energy among the sensor nodes. The routing is based on the flawless hauling range data transmission between base station and cluster heads using multi-hop. Its performance is figured out by comparing with LEACH routing protocol using NS2. It ensures 20% more life time than LEACH protocol.

Proceedings ArticleDOI
01 Feb 2015
TL;DR: The proposed work gives the implementation of efficient edge detection, negative image and image thresholding on Field Programmable Gate Array (FPGA) using Matlab and Simulink and suggests a feasible high-level approach to algorithm implementation for embedded DSP systems.
Abstract: Image enhancement techniques improve the visibility of the images. Enhancement results, the output image is more suitable for a specific application rather than input image. It is used in many image processing applications like medical imaging, SONAR and RADAR as a preprocessing step. Hence this paper presents the hardware co-simulation and implementation of image enhancement algorithms into FPGA. Recent improvements in synthesis tools for Simulink suggest a feasible high-level approach to algorithm implementation for embedded DSP systems. The proposed work gives the implementation of efficient edge detection, negative image and image thresholding on Field Programmable Gate Array (FPGA) using Matlab and Simulink.

Proceedings ArticleDOI
19 Mar 2015
TL;DR: This paper concentrates on the algorithm for extraction of the fiducial points of an ECG signal and its performance analysis, which is targeted onto a ADSP - 2181 to reduce the complexity of the code and obtain optimized power levels.
Abstract: An Electrocardiogram is a significant recording for measuring the electrical activity of the heart. The Feature Extraction of an ECG signal plays a significant role in diagnosing most of the cardiac diseases. This paper concentrates on the algorithm for extraction of the fiducial points of an ECG signal and its performance analysis. To analyze these signals, time-frequency domain is the best suited method. In order to analyze these physiological and non-stationary signals, a Wavelet Transform in which Discrete Wavelet Transform is preferred to Fast Fourier and Short time - Fourier transform. A Discrete Wavelet Transform (DWT) is employed for the better understanding of the ECG signal in Time -Frequency plane with (Haar) as a Mother Wavelet function. The Samples are taken from the available ECG databases PTBDB & QTDB and are checked against the CSE tolerance limits. Since, real time signals like ECG can be easily processed using a DSP processor, the algorithm is targeted onto a ADSP - 2181 to reduce the complexity of the code and obtain optimized power levels.

Journal ArticleDOI
TL;DR: In this paper, the effect of added chloride ions on kinetics and pathway of reaction between cyclic ketones (five to eight membered rings) and dichloroisocyanuric acid (DCICA) was studied in aqueous acetic acid-perchloric acid medium.
Abstract: Effect of added chloride ions on kinetics and pathway of reaction between cyclic ketones (five to eight membered rings) and dichloroisocyanuric acid (DCICA) was studied in aqueous acetic acid—perchloric acid medium. Formation of aliphatic dicarboxylic acids as the end products demonstrates the ring cleavage oxidation. Positive effect of acid and negative effect of dielectric constant on the reaction rate reveals a interaction between positive ion (oxidant in the form of H2OCl+) and dipolar substrate molecule. Zero and first orders by oxidant in absence and presence of added chloride ions illustrates the participation of substrate as enolic form of ketone and protonated ketone, respectively, in the rate determining steps. The observed order of reactivity of cyclic ketones (cyclohexanone > cyclooctanone > cyclopentanone > cycloheptanone) was explained on the bases of ring strain, change of hybridization and conformational considerations. The envisaged plausible mechanism based on order of reactants in presence and absence of added chloride ions was substantiated by the order of Arrhenius parameters.

Proceedings ArticleDOI
13 Jul 2015
TL;DR: The proposed method outperforms other existing methods for the recognition of a speaker based on text dependent speech and is validated on a self generated corpus of size 300 samples of 20 individual.
Abstract: In this paper an efficient approach for the recognition of a speaker based on text dependent speech is presented. Speaker Recognition/ Verification system suffers with wide variety of problems. In the proposed approach, the features are extracted using two methods such as Mel Frequency Cepstral Coefficients and wavelet subband coefficients, and then these futures are fused through concatenation to give optimum performance. Those concatenated feature set are more reliable to discriminate an imposter from the genuine. Those concatenated features are classified using support vector machine classifier. Performance of the proposed approach is validated on a self generated corpus of size 300 samples of 20 individual. The proposed method outperforms other existing methods.

Proceedings ArticleDOI
12 Mar 2015
TL;DR: Simulation studies of the proposed mechanisms show that the blocking probabilities of real-time data secondary devices are much lesser compared to other devices.
Abstract: While designing the cognitive radio networks, enough care would be taken to safeguard the transmissions of primary users so that their quality of service (QoS) is not affected by the transmissions of secondary users. Opportunistic access of the spectrum is permitted to secondary users, through which the vacant channels of the spectrum are used by secondary users on temporary basis. In this mode, when the primary user of that channel returns back for transmission/ reception, the secondary user has to vacate that channel. If that secondary user is engaged in transmitting delay-sensitive (real-time) data, it will lead to severe degradation of its QoS due to this channel quitting requirement. In such instances, if another vacant channel of the spectrum can readily be offered to this secondary user, the device will be able to satisfy its real-time transmission requirements. For this to happen, appropriate categorization of secondary user traffic based on their real-time needs, and planning the usage of vacant channels based on the importance of data from various secondary users are needed. These mechanisms are proposed in this work Simulation studies of the proposed mechanisms show that the blocking probabilities of real-time data secondary devices are much lesser compared to other devices.

Journal ArticleDOI
TL;DR: In this paper, the average edge D-distance of a graph is defined as the average of the distance between all pairs of vertices of the graph, i.e., the distances between all edges in the graph.
Abstract: The D-distance between vertices of a graph G is obtained by considering the path lengths and as well as the degrees of vertices present on the path. The average D-distance of a connected graph is the average of the D-distance between all pairs of vertices of the graph. Similarly, the average edge D-distance is the average of D-distances between all pairs of edges in the graph. In this article we study the average edge D-distance of a graph. We find bounds for average edge D-distance which are sharp and also prove some other results.

Proceedings ArticleDOI
18 Jun 2015
TL;DR: This proposed technique includes non local preprocessing, fuzzy intensification to enhance the quality of the MR images, k-means clustering method for brain tumor segmentation, and the preliminary results show 100% detection rate in all 20 test sets.
Abstract: Brain tumor segmentation for MR images is a difficult and challenging task due to variation in type, size, location and shape of tumors. This paper presents an efficient and fully automatic brain tumor segmentation technique. This proposed technique includes non local preprocessing, fuzzy intensification to enhance the quality of the MR images, k-means clustering method for brain tumor segmentation. The results are evaluated based on accuracy, sensitivity, specificity, false positive rate, false negative rate, Jaccard similarity metric and Dice coefficient. The preliminary results show 100% detection rate in all 20 test sets.

Proceedings ArticleDOI
18 Jun 2015
TL;DR: Hardware implementation of segmentation of brain tumors is carried out using Xilinx System Generator (XSG) and FPGA, resulting in greater performance, less design time and cost than the existing programmable Digital Signal Processors (DSPs) or than even PCs with coprocessors due to lot of parallelism and pipelining.
Abstract: Image segmentation plays an important role in the processing of medical images. Segmentation of medical images is a challenging task due to the poor image contrast and the diffusion of organs or tissue boundaries. Due to the emergence of new trends in the engineering technologies many medical diagnosis methods are automated using the image processing principles. Hence in this paper hardware implementation of segmentation of brain tumors is carried out using Xilinx System Generator (XSG) and FPGA. It results in greater performance, less design time and cost than the existing programmable Digital Signal Processors (DSPs) or than even PCs with coprocessors due to lot of parallelism and pipelining. Use of XSG for medical image processing applications effectively reduces the intricacies existing in architecture design and also provides additional feature of hardware co-simulation.

Journal ArticleDOI
TL;DR: In this paper, supercritical fluid (carbon dioxide) chromatographic methods were developed and validated for the quantitative assay determination of two cancer therapeutic substances, fulvestrant and azacitidine, using a UPC2 system.
Abstract: In the present study, supercritical fluid (carbon dioxide) chromatographic methods were developed and validated for the quantitative assay determination of two cancer therapeutic substances, fulvestrant and azacitidine, using a UPC2 system. Fulvestrant was separated from six potential impurities, while impurities of azacitidine were separated using a 150 mm × 4.6 mm, I.D., a chiral column and 5 μm, particle size. Both drugs were analysed simultaneously in a single sequence using multiple channels in the system and respective methods. These new methods were validated for their intended purpose in accordance with the current ICH guidelines. The method exhibited excellent intra- and inter-day precision. A precision with RSD 1% and 1.6% was achieved for fulvestrant and azacitidine, respectively. A linear relationship r2 > 0.999 was achieved between the concentration and detector response over a range of 25–150% of the target concentrations for both compounds. The two compounds were well quantified from their unspecified impurities obtained from stress studies. The method can be employed for routine quality control testing and stability analysis.

Proceedings ArticleDOI
01 Dec 2015
TL;DR: In this article, a high frequency sinusoidal oscillator using positive second generation current controlled conveyor (CCCII+) with minimum passive components is presented, which is suitable for monolithic IC fabrication.
Abstract: The immense work presented in this paper is a high frequency sinusoidal oscillator using positive second generation current controlled conveyor (CCCII+) with minimum passive components. CCCII is implemented using single Current Feedback Operational Amplifier (CFOA) and single Operational Trans-conductance Amplifier (OTA). The frequency (time period) of CCCII is tuned to a maximum of 4 MHz using external bias current. The performance of the proposed circuit is practically verified using ICs AD844 (CFOA) and LM 13700 (OTA) and its results are included. The topology is suitable for monolithic IC fabrication.

Journal ArticleDOI
TL;DR: A novel palmprint identification and verification algorithm based on wide principal lines through dynamic ROI that extracts better ROI on the PolyUPalmprint Database when compared to the existing fixed size and dynamic size ROI extraction techniques.
Abstract: In this paper, a novel palmprint identification and verification algorithm is proposed based on wide principal lines through dynamic ROI. Region of interest ROI extraction is an important task for palmprint identification. Earlier reported works used fixed size ROI for the recognition of palmprints. When the fixed size ROI is used the palm area taken up for recognition is less compared to dynamic ROI extraction. The proposed algorithm focuses on extraction of maximum possible ROI. A set of wide principal line extractors are devised. Later these wide principal line extractors are used to extract the wide principal lines from dynamic ROI. A two stage palmprint identification algorithm is proposed based on wide principal lines. The experimental results demonstrate that the proposed approach extracts better ROI on the PolyUPalmprint Database when compared to the existing fixed size and dynamic size ROI extraction techniques. The experimental results for the verification and identification on PolyUPalmprint Database show that the discrimination of wide principal lines is also strong.

Proceedings ArticleDOI
12 Mar 2015
TL;DR: Two new Schmitt trigger circuits with eight enhancement-type MOS transistors are introduced in this paper and are preferred for high speed applications and also useful in low power applications.
Abstract: This paper presents two new Schmitt trigger circuits with eight enhancement-type MOS transistors are introduced in this paper. These two Schmitt trigger circuits are implemented based on current sink and current source inverters. The hysteresis curves of the proposed Schmitt triggers are presented, hysteresis width depends on the supply voltage and transistor geometry. These circuits are preferred for high speed applications and also useful in low power applications. The performances of proposed circuits are examined using Cadence and model parameters of 180 nm CMOS technology with supply rail voltage of +3V. The simulation results and layouts are presented with optimized sizing and spacing in compliance to the design rules of gpdk 180 nm CMOS process.

Proceedings ArticleDOI
01 Jan 2015
TL;DR: A new hybrid rule extraction method for OCSVM is proposed, composed with Support Vector Data Description (SVDD) and RIPPER rule learning and obtained results have shown that SVDD+RIPPER hybrid outperformed SVDd and RIP PER alone in terms of classification performance and explanation ability.
Abstract: One-Class Support Vector Machines (OCSVM) is widely applied for those classification problems where one of the classes of data is completely not present or not properly sampled However, the knowledge presented by OCSVM is not interpretable by the human analyst To ameliorate this problem there is a need for providing explanation aids to OCSVM classification decisions Recently, several rule extraction methods were evolved to provide explanation ability to Support Vector Machines (SVM) and Artificial Neural Networks (ANN) Motivated from these methods this paper proposes a new hybrid rule extraction method for OCSVM, which is not widely studied yet Proposed hybrid is composed with Support Vector Data Description (SVDD) and RIPPER rule learning The viability of the proposed hybrid is tested over three benchmark datasets Obtained results have shown that SVDD+RIPPER hybrid outperformed SVDD and RIPPER alone in terms of classification performance and explanation ability

Journal ArticleDOI
TL;DR: Results from this study show that a prokaryotic expression system can be used for generating large amounts of rgpTNF-α without concern for the biological integrity, and it is concluded that the eukaryotic-expressed r gpT NF-α lacks posttranslational modifications.
Abstract: Tumor necrosis factor alpha (TNF-α) is a cytokine which plays opposing roles in the context of infectious disease pathogenesis. TNF-α is essential for the development of a protective immune response to some pathogens, for example, Mycobacterium tuberculosis, by synergizing with other cytokines. However, exorbitant or uncontrolled TNF-α activity may also drive pathology and disease symptoms in many infectious diseases. In order to elucidate the beneficial and detrimental roles of TNF-α in tuberculosis (TB) and other diseases for which the guinea pig is the small animal model of choice, recombinant guinea pig (rgp)TNF-α has been produced using prokaryotic expression systems. However, it is unknown whether posttranslational modifications which cannot be made in the prokaryotic expression systems may be important for rgpTNF-α structure and function. Therefore, we carried out a comparative study by expressing rgpTNF-α in prokaryotic and eukaryotic expression systems and analyzed the eukaryotic-expressed rgpTNF-α for the presence of posttranslational modifications by subjecting it to NanoLC-MS/MS. We conclude that the eukaryotic-expressed rgpTNF-α lacks posttranslational modifications, and we found no significant difference in terms of the biological activity between prokaryotic- and eukaryotic-expressed rgpTNF-α. Taken together, results from our study show that a prokaryotic expression system can be used for generating large amounts of rgpTNF-α without concern for the biological integrity.

Journal ArticleDOI
TL;DR: A concise, economical, and highly enantioselective synthesis of bismesylate intermediate of lurasidone HCl, an antipsychotic, has been developed as mentioned in this paper.