Vignan University

About: Vignan University is a education organization based out in Guntur, Andhra Pradesh, India. It is known for research contribution in the topics: Computer science & Control theory. The organization has 1138 authors who have published 1381 publications receiving 7798 citations.

Development of universal purification protocols for fibrinolytic enzyme-producing bacilli

Abstract: An aqueous protocol was developed for nattokinase purification under scalable conditions using a combination of salting out, anion exchange chromatography and ultra-filtration. The enzyme was first...

Estimating the failure strength of fiber metal laminates by using a hybrid degradation model

Abstract: Different analytical formulations are reported in recent works to model the failure strength and the progressive failure of different fiber metal laminates (FMLs). Although the basis for all these formulations is classical lamination theory (CLT), the models differ with each other while modeling the stiffness degradation. A common analytical formulation that is independent of configuration of the laminate will be very helpful for the designers in this field. Present work is aimed to develop such a model with the help of a hybrid degradation scheme, which uses constant degradation factors based on the condition of the adjacent lamina. This hybrid degradation scheme has helped to model the occurrence of multiple failures inside a lamina during failure progression. The formulation is tested with three types of FMLs and the results show that the formulation is very much helpful in predicting the failure strength and progressive failure.

Mineralogy and geochemistry of the sediments in rivers along the east coast of India: Inferences on weathering and provenance

Abstract: The clay fraction of the sediments in 15 rivers along the east coast of India showed The clay fraction of sediments in the lower reaches of 15 rivers along the east coast of India showed high kaolinite followed by illite and smectite for the rivers dominantly draining the Archaean–Precambrian Terrain (APT), high smectite followed by illite and kaolinite for those draining the Deccan Trap Volcanic Terrain (DVT) and, high illite followed by kaolinite, smectite or chlorite for those draining through Mixed-Lithology Terrain (MLT) The CIA (Chemical Index of Alteration) and PIA (Plagioclase Index of Alteration) values, depletion of Ca, K, Na and Sr and enrichment of Al, Fe and Ti, high Rb/Sr and Th/U ratios of sediments relative to the Upper Continental Crust indicate moderate to intense chemical weathering on source rocks The average composition of clays exhibits slight enrichment of Fe, Mg, Sc, V, Co, Cr and Ni and depletion of Nb, Zr, Hf, Y and Ta relative to the Post-Archaean average Australian Shale The Cu, Zn and Pb contents were in the range ‘significantly polluted to moderately polluted’ in APT- and DVT-sediments The plots of TiO2 vs Fe2O3+MgO, Th/Sc vs Sc and La–Th–Sc showed sediment composition intermediate between granite and basalt, while the plots of TiO2 vs Zr, Th vs Sc and V–Ni–Th indicate intermediate provenance between mafic and felsic sources The mineralogy of the sediments indicates mixed sources, but their chemical composition is affected by weathering and the provenance is intermediate between mafic and felsic sources

Congestion-aware wireless network-on-chip for high-speed communication

Abstract: The design of system-on-chip (SoC) requires the complex integration between a multi-number of cores on a single chip. To establish the effective communication between multiple cores there aremore c...

Impurity profiling and stability-indicating method development and validation for the estimation of assay and degradation impurities of midostaurin in softgel capsules using HPLC and LC-MS.

Abstract: Midostaurin (MDS) is used for the treatment of acute myeloid leukemia, myelodysplastic syndrome, and advanced systemic mastocytosis. MDS softgel capsule samples were subjected to stress testing per International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use guidelines for impurity profiling study. MDS underwent extensive degradation under stress testing (acid, alkaline, oxidative, photolytic, thermolytic, and hydrolysis conditions) and formed four degradation products (DPs). MDS and its DPs were separated well from one another with good resolution using reserved-phase HPLC using an Inertsil ODS-3V column (250 × 4.6 mm, 5 μm) and a mobile phase of ammonium formate (40 mM) and acetonitrile. The stability-indicating characteristic of the newly developed method was proven for the estimation of MDS assay, and its organic impurities were free from interference. The validated method exhibited excellent linearity, accuracy, precision, specificity, detection limit, and quantitation limit within 25 min run time. Stress testing, robustness, and solution stability were performed to ensure the continuous performance of the developed method. The peak fractions of DPs formed under stress testing were isolated and characterized using LC-MS, 1 H and 13 C NMR, IR, and UV-Vis. The structure of the major DPs was predicted as DP1 based on the spectral data. The proposed method is effectively used for MDS in bulk drug and finished formulations in the pharmaceutical industry.