Institution
Vignan University
Education•Guntur, Andhra Pradesh, India•
About: Vignan University is a education organization based out in Guntur, Andhra Pradesh, India. It is known for research contribution in the topics: Control theory & CMOS. The organization has 1138 authors who have published 1381 publications receiving 7798 citations.
Topics: Control theory, CMOS, Cement, Machining, Wireless sensor network
Papers
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TL;DR: These findings provide supportive evidence for the newly proposed oxygen-centric chemical-coupling mechanism (murburn concept), wherein DROS catalyzes the esterification of inorganic phosphate to ADP.
Abstract: The inner mitochondrial membrane protein complexes (I-V) and prokaryotic respiratory machinery are examined for a deeper understanding of their structure-function correlations and dynamics. In silico analysis of the structure of complexes I-IV, docking studies and erstwhile literature confirm that they carry sites which are in close proximity to DROS (diffusible reactive oxygen species) generating redox centers. These findings provide supportive evidence for the newly proposed oxygen-centric chemical-coupling mechanism (murburn concept), wherein DROS catalyzes the esterification of inorganic phosphate to ADP. Further, in a reductionist system, we demonstrate that a DROS (like superoxide) can effectively esterify inorganic phosphate to ADP. The impact of these findings and the interactive dynamics of classical inhibitors (rotenone and cyanide), uncouplers (dinitrophenol and uncoupling protein) and other toxins (atractyloside and oligomycin) are briefly discussed. Highlights • Earlier perception: Complexes (I-IV) pump protons and Complex V make ATP (aided by protons) • Herein: Respiratory molecular machinery is probed for new structure-function correlations • Analyses: Quantitative arguments discount proton-centric ATP synthesis in mitochondria and bacteria • In silico data: ADP-binding sites and O2/ diffusible reactive oxygen species (DROS)-accessible channels are unveiled in respiratory proteins • In vitro data: Using luminometry, ATP synthesis is demonstrated from ADP, Pi and superoxide • Inference: Findings agree with decentralized ADP-Pi activation via oxygen-centric murburn scheme Communicated by Ramaswamy H. Sarma.
28 citations
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TL;DR: The OWAF showed superior performance than existing conventional fusion approaches in terms of information mapping, edge quality and structural similarity in MR/PET, MR/SPECT and MR/CT images in both normal and noisy fusion backgrounds.
28 citations
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28 citations
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TL;DR: In this paper, running of faulty induction motors and its associated financial losses have been addressed and an algorithm has been proposed for planning maintenance actions based on operational losses due to faulty motor.
28 citations
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TL;DR: Docking and in vitro studies of dihydrobenzimidazo pyrimidine derivatives against acetylcholinesterase (AChE) have been performed and the compounds 3d and 3e exhibit potent inhibitory activities with an IC50 of 46.8 nM and 42.5 nM respectively.
Abstract: A wide array of dihydro[1,5]azo[1,2-a]pyrimidine 2-esters have been synthesised at room temperature in moderate to good yields through one-pot reaction between nitrostyrene derived MBH acetates and aminoazole derivatives with γ-α cyclisation. The reaction involves a cascade SN2 reaction followed by intramolecular Michael addition–cyclisation with the generation of two new carbon–nitrogen bonds. The structure was further confirmed by single X-ray crystal analysis. Docking and in vitro studies of dihydrobenzimidazo pyrimidine derivatives against acetylcholinesterase (AChE) have been performed and the compounds 3d and 3e exhibit potent inhibitory activities with an IC50 of 46.8 nM and 42.5 nM respectively.
28 citations
Authors
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Name | H-index | Papers | Citations |
---|---|---|---|
Muthukaruppan Alagar | 40 | 316 | 5914 |
Ebenezer Daniel | 40 | 180 | 5597 |
P. B. Kavi Kishor | 30 | 123 | 3486 |
V. Purnachandra Rao | 26 | 59 | 1723 |
Muddu Sekhar | 24 | 135 | 1929 |
Anandarup Goswami | 23 | 44 | 5427 |
Reddymasu Sreenivasulu | 20 | 58 | 925 |
Murthy Chavali | 20 | 105 | 1699 |
Krishna P. Kota | 20 | 42 | 1172 |
Naveen Mulakayala | 17 | 39 | 937 |
Tondepu Subbaiah | 16 | 65 | 773 |
Bharat Kumar Tripuramallu | 15 | 34 | 574 |
Avireni Srinivasulu | 13 | 97 | 626 |
Abhinav Parashar | 13 | 29 | 375 |
Umesh Chandra | 13 | 39 | 550 |