Vignan University

About: Vignan University is a education organization based out in Guntur, Andhra Pradesh, India. It is known for research contribution in the topics: Computer science & Control theory. The organization has 1138 authors who have published 1381 publications receiving 7798 citations.

Dynamic Weighted Feature Subset Logistic Regression Model for Heart Disease Prediction

Abstract: Predicting heart disease is one of the medical industry's toughest challenges. Heart disease, also known as cardiovascular disease, is an umbrella term for a variety of conditions affecting the cardiovascular system. It is estimated that approximately one person dies every minute due to cardiovascular illness. Death from cardiovascular disease is the leading cause of mortality in the United States. Many forms of heart disease are both preventable and treatable. Early diagnosis can help in preventing unnecessary deaths and increasing the likelihood of survival. It takes data science to process the massive amounts of data generated by the healthcare sector. Since cardiac disease prediction is difficult, automation is required to minimise risks and provide early warning to the patient. In this article, different Machine Learning methods such as Multinomial, Support Vector Classifier and Logistic Regression are compared. As a result of the experimental findings, it is determined that Logistic Regression is the most accurate technique for detecting whether a person has heart disease or not, with an accuracy of 83 percent.

Conserved envelope protein of nCoV2 as the possible target to design polytope vaccine

Abstract: Aim: The envelope protein of novel coronavirus 2 (nCoV2) was reported to be highly conserved compared to its spike (S) protein which was shown to undergo several alterations in their amino acid sequences in the span of one year (2020–2021). Therefore, it is aimed to consider highly conserved structural protein of nCov2 namely envelope (E) protein to design the polytope for the formulation of the vaccine against coronavirus disease 2019 (Covid-19). Methods: Online in silico tools were employed to decipher the conservancy and antigenicity of E-protein of nCoV2. They are: to evaluate the molecular affinities among the chosen representatives of alpha and beta coronaviruses, the Molecular Evolutionary Genetics Analysis (MEGA) X 10.1.1 was used. Immune Epitope Database (IEDB)-NetMHCpan (ver. 4.1) tool was used to predict the epitopes of E protein binding to the frequently distributed major histocompatibility complex (MHC) I alleles. ProtParam, VaxJen, ToxinPred and AllerTop online tools were used to assess the physicochemical features, antigenicity, non-toxin and non-allergen aspects of constructed polytope. Secondary structure analysis and homology modelling validation of polytope were done using Phyre2 online tool. Discontinuous and linear epitopes of the designed polytope were predicted through IEDB Ellipro tool. Population coverage of epitopes of the polytope was performed using IEDB online tool with the frequent distribution of human leukocyte antigen (HLA) I alleles in the South Indian Asian population. Results: The phylogeny of envelope proteins of chosen representatives of Coronaviridae confirmed its conservancy and possible origin of nCoV2 from alpha coronaviruses through vampire CoV2. The designed polytope of E-protein was with 53 amino acid residues. The same was developed by linking with cysteine and serine (CS) residues in between epitopes. Conclusion: The antigenicity, non-allergen, non-toxin, homology modelling, discontinuous and linear epitopes of the designed polytope authenticate to explore the envelope protein for prophylactic measures. The epitopes of polytope were found to restrict to MHC I alleles occurring frequently among South Indian Asians.

Installation Automation Tool

Abstract: Installation automation tool is aimed to reduce the human effort involved in software installation and uninstallation tasks in environments where a set of software applications are needed to be installed or uninstalled over a set of systems with same specifications. The main aim is to reduce the necessity of human presence through the process. So, this tool can be used to add or remove software over multiple systems by automating the parts which needs human intervention. This can be a great help in, which involves a large number of systems being connected and treated as a whole and help will be provided across all the systems.

Preparation and characterization of a novel sprayable hydrogel for skin preparation to record ECG and other biopotentials

Abstract: Wet electrodes are widely used to perform biopotential measurements from the body, such as electroencephalogram, electrocardiogram, and electromyogram. These electrodes have certain disadvantages, including bacterial growth, irritation in long-term recordings, infection to patients’ skin caused by skin preparation techniques, and unpleasant feeling caused after their removal. Thus, a sprayable hydrogel (SH) was designed to avoid these problems. Five electrode configurations, namely, Zipprep™, wet Ag/AgCl, wipes, dry Ag/AgCl, and SH, were tested using an impedance analyzer. Measurements were obtained by placing each of the electrode systems on the forearm of five subjects, which comprised one Caucasian, two Indians, one Syrian, and one Cypriot aging between 23 and 60 years for 10 min. Impedance versus time and reactance versus resistance performance plots were compared and assessed. The performance of the SH sprayed under dry electrodes had lower impedance values compared with those of the dry Ag/AgCl and wipes. As a result, the SH electrode configuration can be used as an electrode set-up for acquiring and recording various physiological signals.

Dual Band Coplanar Waveguide Fed Antenna With Dual Polarization Characteristics

Abstract: This letter presents a multi band antenna which exhibits both circular polarized and linear polarized characteristics. A rectangular slot is etched in the ground plane and is energized by coplanar waveguide feed. Grounded stub is placed in the close proximity of the radiating patch inorder to produce circular polarization. The proposed antenna exhibits dual band characteristics with lower band circular polarized and upper band linear polarized. Undesired higher order modes are suppressed by using a rectangular stub directly attached to the feed line. The overlapping circular polarized lower band i.e. VSWR ≤ 2 dB and Axial ratio ≤ dB extends from 3.02 GHz – 4.04 GHz while linear polarized higher band extends from 5.05 GHz – 5.94 GHz, thereby proposed antenna covers WiMAX and WLAN application bands.