Vignan University

About: Vignan University is a education organization based out in Guntur, Andhra Pradesh, India. It is known for research contribution in the topics: Control theory & CMOS. The organization has 1138 authors who have published 1381 publications receiving 7798 citations.

Spurious hypothyroidism!

Abstract: Sir, A 27-year-old female with primary hypothyroidism had stable thyroid-stimulating hormone (TSH) levels with levothyroxine (LT4) 100 mg/day for 5 years. She was contemplating pregnancy. She noticed puffiness of the face, weight gain of 2–3 kg, excessive hair loss, and menstrual irregularity for the past 3 months. Repeated serum TSH levels were above 100 mIU/ml. She was compliant with her medications, had even resorted to taking tablets after crushing it, and avoids food or beverages for an hour after taking LT4. She was using the same brand of LT4 since diagnosis. She was not taking any supplements/other medications. Her workup did not show any features, suggestive of malabsorption. Her urine pregnancy test was negative. The patient on optimum treatment and adherence needs evaluation in clinical scenario of unexpected fluctuations or persistent elevations in the serum TSH. The factors affecting LT4 formulation, absorption, and metabolism need to be investigated as potential culprits. LT4 formulation gets affected by the expiry of pills and environmental factors. The usual causes are gastrointestinal malabsorption,[1] drug interference for absorption, or metabolism of LT4.[2] The medication bottle had a suspicious label with few other discrepancies. Same label mentioned two different strengths, 100 mg and 50 mg. The hologram was noted hazy, and the QR code failed to play the informative video. Due to the above observations, a trial with different proprietary LT4 of similar strength resolved her symptoms and normalized TSH to 1.4 uIU/ml within 8 weeks. This confirmed that the previous drug was not delivering the dosage as marked on the bottle. This is in contrary to the American Thyroid Association’s recommendation of consistent use of the same identifiable formulation of LT4[3] for its usual lifelong therapy. The above scenario makes an exception for this practice. Spurious drug use should be considered as a possibility before enhancing the drug dosage in previously euthyroid with stable optimum dose of LT4. Declaration of patient consent The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.

Image Fusion Technique Using Gaussian Pyramid.

Abstract: The aim of image fusion is to combine similar information from multiple images into a single image. The methods which are based on discrete cosine transform (DCT) of image fusion are more competent and time-saving in real-time systems using DCT based standards of still Image. The existing DCT based methods are suffering from some side effects like blurring which can reduce the quality of the output image. To address this issue, the paper proposing new method for image fusion using Gaussian pyramid in DCT domain. The pyramid fusion provides better fusion quality. The execution time is extremely reduced, compare with existing methods. This method can be used for multi model image fusion as well as fusion of complementary images. The algorithm given in proposed system is simple and easy to implement. Also, it could be used for real time applications. The performance of our method is analyzed and compared with other image fusion methods. Experimental results show that there is no difference between the result of our method and water-based image fusion result. But our algorithm is carried out in DCT domain; it is efficient in processing time and simple.

OFET based H 2 S gas sensing among reducing and mining gases using green synthesis SnO 2

Abstract: In this paper we present detection of H 2 S gas using an organic field effect transistor (OFET) based sensor. A low-cost green synthesis process for SnO 2 nanoparticles and bi-layer approach for device fabrication have been adopted to come up with the sensor. With the help of multiparameteric analysis, selectivity towards H2S gas was proved among other reducing and mining gases.