Showing papers by "Virginia Commonwealth University published in 1968"
TL;DR: It appears that humoral cytotoxic antibodies are associated with kidney transplant rejections and that they either act directly on the transplant or serve as indicators of a state of presensitization.
Abstract: SUMMARY A total of 231 serum samples from 41 patients before and after first and second kidney transplants were investigated for the presence of cytotoxic antibodies. After transplantation 11 of 29 patients had cytotoxic antibodies in contrast to 4 of 21 patients before transplantation. In 10 patients who had their renal grafts removed because of rejection, 9 had demonstrable cytotoxic antibodies. Patients with cytotoxins generally tended to have worse kidney function and transplant failure than patients without cytotoxins (P
85 citations
TL;DR: Evidence that transplantation antibodies are removed from the recipient's circulation by the functioning graft was found and some evidence for the possible participation of humoral antibodies in rejection of renal grafts was brought.
Abstract: Transplantation antibodies in the sera of eight patients who survived rejection of one or two renal grafts were studied by the mixed agglutination tests with cell cultures. Evidence that transplantation antibodies are removed from the recipient's circulation by the functioning graft was as follows: (1) the antibodies were detected in sera of the patients during the terminal stage of rejection or after the removal of the graft but never during the normal function of the graft; (2) the antibodies could be eluted from the rejected grafts. Present data also brought some evidence for the possible participation of humoral antibodies in rejection of renal grafts.
21 citations
TL;DR: It was demonstrated that lymphocytes produced a greater increase in vascular resistance in theallogeneic kidney, and that more cells were retained in the allogeneic than in the isogeneic rat kidneys.
Abstract: SUMMARY The hemodynamic effects of unsensitized small lymphocytes were studied, during simultaneous ex vivo perfusion of allogeneic and isogeneic rat kidneys. It was demonstrated that lymphocytes produced a greater increase in vascular resistance in the allogeneic kidney, and that more cells were retained in the allogeneic than in the isogeneic kidney. The effects were interpreted as “allogeneic adsorption” between cells of different genotypes.
5 citations