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Institution

Virginia Commonwealth University

EducationRichmond, Virginia, United States
About: Virginia Commonwealth University is a education organization based out in Richmond, Virginia, United States. It is known for research contribution in the topics: Population & Health care. The organization has 23822 authors who have published 49587 publications receiving 1787046 citations. The organization is also known as: VCU.


Papers
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Journal ArticleDOI
TL;DR: The results suggest that the selective modulation of nociceptive input at the level of the spinal cord can be mediated by a supraspinal system or systems physiologically distinct from those involved in analgesia produced by the administration of opiates.

409 citations

Journal ArticleDOI
TL;DR: The group recommends that postmenopausal women and men aged 50 years should be diagnosed with osteoporosis if they have a demonstrable elevated risk for future fractures and should be used to diagnose individuals with an elevated fracture risk based on the World Health Organization Fracture Risk Algorithm, FRAX.
Abstract: Summary Osteoporosis causes an elevated fracture risk. We propose the continued use of T-scores as one means for diagnosis but recommend that, alternatively, hip fracture; osteopenia-associated vertebral, proximal humerus, pelvis, or some wrist fractures; or FRAX scores with ≥3 % (hip) or 20 % (major) 10-year fracture risk also confer an osteoporosis diagnosis.

409 citations

Journal ArticleDOI
TL;DR: The inhibitory effect of uropontin on calcium oxalate crystal growth in vitro supports the concept that pontins may have a regulatory role, analogous to that of other members of the aspartic acid-rich protein superfamily, which stereospecifically regulate the mineralization fronts of calcium-containing crystals.
Abstract: The majority of human urinary stones are primarily composed of calcium salts. Although normal urine is frequently supersaturated with respect to calcium oxalate, most humans do not form stones. Inhibitors are among the multiple factors that may influence the complex process of urinary stone formation. We have isolated an inhibitor of calcium oxalate crystal growth from human urine by monoclonal antibody immunoaffinity chromatography. The N-terminal amino acid sequence and acidic amino acid content of this aspartic acid-rich protein, uropontin, are similar to those of other pontin proteins from bone, plasma, breast milk, and cells. The inhibitory effect of uropontin on calcium oxalate crystal growth in vitro supports the concept that pontins may have a regulatory role. This function would be analogous to that of other members of the aspartic acid-rich protein superfamily, which stereospecifically regulate the mineralization fronts of calcium-containing crystals.

407 citations

Journal ArticleDOI
TL;DR: Using density-functional calculations, the design principles for atomic clusters with suitable size and composition are outlined and the role of geometry and electronic shell structure on cluster-cluster interaction is described.
Abstract: Atomic clusters with suitable size and composition can be designed to mimic the chemistry of atoms in the Periodic Table. These clusters which can be viewed as ``super atoms'' could then form the building blocks for a class of solids with unique structural, electronic, optical, magnetic, and thermodynamic properties. Using density-functional calculations, we outline the design principles for these clusters and describe the role of geometry and electronic shell structure on cluster-cluster interaction.

407 citations


Authors

Showing all 24085 results

NameH-indexPapersCitations
Ronald C. Kessler2741332328983
Carlo M. Croce1981135189007
Nicholas G. Martin1921770161952
Michael Rutter188676151592
Kenneth S. Kendler1771327142251
Bernhard O. Palsson14783185051
Thomas J. Smith1401775113919
Ming T. Tsuang14088573865
Patrick F. Sullivan13359492298
Martin B. Keller13154165069
Michael E. Thase13192375995
Benjamin F. Cravatt13166661932
Jian Zhou128300791402
Rena R. Wing12864967360
Linda R. Watkins12751956454
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202395
2022395
20213,659
20203,437
20193,039
20182,758