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Institution

Virginia Commonwealth University

EducationRichmond, Virginia, United States
About: Virginia Commonwealth University is a education organization based out in Richmond, Virginia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 23822 authors who have published 49587 publications receiving 1787046 citations. The organization is also known as: VCU.


Papers
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Journal ArticleDOI
TL;DR: The overall magnitude of harms to the fetus is small to moderate and the USPSTF recommends diagnosis and treatment as a grade B definition, and that treatment of pregnant and postpartum women with depression using CBT improves clinical outcomes.
Abstract: Description Update of the 2009 US Preventive Services Task Force (USPSTF) recommendation on screening for depression in adults. Methods The USPSTF reviewed the evidence on the benefits and harms of screening for depression in adult populations, including older adults and pregnant and postpartum women; the accuracy of depression screening instruments; and the benefits and harms of depression treatment in these populations. Population This recommendation applies to adults 18 years and older. Recommendation The USPSTF recommends screening for depression in the general adult population, including pregnant and postpartum women. Screening should be implemented with adequate systems in place to ensure accurate diagnosis, effective treatment, and appropriate follow-up. (B recommendation)

287 citations

Journal ArticleDOI
01 Jan 2002-Drugs
TL;DR: Fixed-dose combination therapy has a proven record of reducing BP and if made truly cost-competitive, it will gain an increasing share of the hypertensive market if not, market forces will relegate it to a secondary role for hypertension treatment.
Abstract: Single-drug therapy remains the preferred way to begin treatment of hypertension, although in many patients this is unable to bring blood pressure (BP) to goal levels. Single-drug therapy, even when maximally titrated, is at best only modestly effective in normalising BP in Stage-I or II hypertension, which represents the majority of the hypertensive population. It is increasingly appreciated that the elusive goal of a ‘normal’ BP is achieved only if multi-drug therapy is employed. This is especially so when considered in the context of today’s lower BP goals. The options for multi-drug therapy are quite simple: either fixed-dose combination therapy or drugs added sequentially one after another to then arrive at an effective multi-drug regimen. Advocates exist for both approaches. A considerable legacy, dating to the 1950’s, exists for fixed-dose combination therapies. The rationale to this approach has remained constant. Fixed-dose combination therapy successfully reduces BP because two drugs, each typically working at a separate site, block different effector pathways. In addition, the second drug of such two-drug combinations may check counter-regulatory system activity triggered by the other. For example, a diuretic and β-blocker combination may find the diuretic correcting the salt-and-water retention which occasionally accompanies β-blocker therapy. The pattern of adverse effects also differs with fixed-dose combination therapy, in part, because less drug is generally being given. In addition, one component of a fixed-dose combination therapy can effectively counterbalance the tendency of the other to produce adverse effects. For example, the peripheral oedema, that accompanies calcium channel antagonist therapy, occurs less frequently when an ACE inhibitor is co-administered. ACE inhibitors improve, if not eliminate, the peripheral oedema associated with calcium channel antagonists because of their proven ability to cause venodilation. In addition, diuretic therapy-induced volume contraction may generate a state of secondary hyperaldosteronism and thereby electrolyte abnormalities such as hypokalaemia and/or hypomagnesaemia. In many cases, the co-administration of either an ACE inhibitor or an angiotensin II receptor blocker with a diuretic corrects the aforementioned electrolyte disturbances. Fixed-dose combination therapy has a proven record of reducing BP. This form of treatment has been available for close to a half-century. Over that period of time, many physicians have taken advantage of this therapeutic approach even when academic opinion was less than charitable to this concept. Academic opinion is rarely immutable and occasionally irrelevant to prescription practice. Prescription practice is driven by many considerations including ease of use, cost and tolerance of a therapy. Most importantly, the therapeutic pathway taken should successfully result in goal BP being reached in a large number of those treated. Unfortunately, despite the simplicity of the concept behind fixed-dose combination therapy, its success will ultimately rest on cost. If made truly cost-competitive, it will gain an increasing share of the hypertensive market. If not, market forces will relegate it to a secondary role for hypertension treatment.

287 citations

Journal ArticleDOI
TL;DR: In this paper, the fundamental understanding of the lithium-insertion/extraction mechanism in alloy anodes is discussed and the effect of interface and surface energies on the phase transformation and thermodynamic stability of fine alloy particles is discussed.

287 citations

Journal ArticleDOI
TL;DR: The observed trends support the essential role of the mobile proton model in understanding peptide fragmentation by low-energy tandem mass spectrometry.
Abstract: The utility of surface-induced dissociation (SID) to probe the structure, energetics and fragmentation mechanisms of protonated peptides is discussed and demonstrated. High internal energy deposition provided by low-energy (eV range) ion-surface collisions yields extensive fragmentation of protonated peptides, allowing relatively uncomplicated and rapid sequence analysis of oligopeptides. SID of multiply protonated peptides is illustrated for peptides with molecular mass of up to approximately 5000 u. It is also illustrated that SID combined with electrospray ionization (ESI) provides a distinctive experimental technique to determine the energetics and mechanisms of peptide fragmentation. The relative position of ESI/SID fragmentation efficiency curves (plots of percentage fragmentation vs. laboratory collision energy) for peptides can be utilized to estimate relative energetics of peptide fragmentation and even to predict proton localization sites. The observed trends support the essential role of the mobile proton model in understanding peptide fragmentation by low-energy tandem mass spectrometry.

287 citations

Journal ArticleDOI
TL;DR: In this paper, the authors present the theory and development of an algorithm associated with the exploration of a dual response surface system, where a user can generate simple two dimensional plots to determine the conditions of constrained maximum primary response regardless of the number of independent variables in the system.
Abstract: The purpose of this paper is to present the theory and develop an algorithm associated with the exploration of a dual response surface system. The approach is to find conditions on a set of independent or “design” variables which maximize (or minimize) a “primary response” function subject to the condition that a “constraint response” function takes on some specified or desirable value. A method is outlined whereby a user can generate simple two dimensional plots to determine the conditions of constrained maximum primary response regardless of the number of independent variables in the system. He thus is able to reduce to simple plotting the complex task of exploring the dual response system. The procedure that is used to generate the plots depends on the nature of the individual univariate response functions. In certain situations it becomes necessary to apply the additional constraint that the located operating conditions are a certain “distance” from the origin of the independent variables (or the cent...

287 citations


Authors

Showing all 24085 results

NameH-indexPapersCitations
Ronald C. Kessler2741332328983
Carlo M. Croce1981135189007
Nicholas G. Martin1921770161952
Michael Rutter188676151592
Kenneth S. Kendler1771327142251
Bernhard O. Palsson14783185051
Thomas J. Smith1401775113919
Ming T. Tsuang14088573865
Patrick F. Sullivan13359492298
Martin B. Keller13154165069
Michael E. Thase13192375995
Benjamin F. Cravatt13166661932
Jian Zhou128300791402
Rena R. Wing12864967360
Linda R. Watkins12751956454
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202395
2022395
20213,658
20203,437
20193,039
20182,758