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Institution

Virginia Commonwealth University

EducationRichmond, Virginia, United States
About: Virginia Commonwealth University is a education organization based out in Richmond, Virginia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 23822 authors who have published 49587 publications receiving 1787046 citations. The organization is also known as: VCU.


Papers
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Journal ArticleDOI
TL;DR: The data indicate that ceftriaxone is a potent modulator of glutamate transport in PHFA through NF-κB-mediated EAAT2 promoter activation, and suggest a mechanism for ceftRIaxone modulation of glutamate Transport and for its potential effects on ameliorating specific neurodegenerative diseases through modulation of extracellular glutamate.

287 citations

Journal ArticleDOI
TL;DR: It is demonstrated that BAY 43-9006 mediates cell death in human leukemia cells, at least in part, through down-regulation of Mcl-1 via inhibition of translation.

286 citations

Journal ArticleDOI
TL;DR: Severe asthma is associated with a predominance of MC(TC) in the airway submucosa and epithelium, and the data suggest an altered and active MC population contributes to SA pathology.
Abstract: Rationale: Severe asthma (SA) remains poorly understood. Mast cells (MC) are implicated in asthma pathogenesis, but it remains unknown how their phenotype, location, and activation relate to asthma severity. Objectives: To compare MC-related markers measured in bronchoscopically obtained samples with clinically relevant parameters between normal subjects and subjects with asthma to clarify their pathobiologic importance. Methods: Endobronchial biopsies, epithelial brushings, and bronchoalveolar lavage were obtained from subjects with asthma and normal subjects from the Severe Asthma Research Program (N = 199). Tryptase, chymase, and carboxypeptidase A (CPA)3 were used to identify total MC (MCTot) and the MCTC subset (MCs positive for both tryptase and chymase) using immunostaining and quantitative real-time polymerase chain reaction. Lavage was analyzed for tryptase and prostaglandin D2 (PGD2) by ELISA. Measurements and Main Results: Submucosal MCTot (tryptase-positive by immunostaining) numbers were highest in “mild asthma/no inhaled corticosteroid (ICS) therapy” subjects and decreased with greater asthma severity (P = 0.002). In contrast, MCTC (chymase-positive by immunostaining) were the predominant (MCTC/MCTot > 50%) MC phenotype in SA (overall P = 0.005). Epithelial MCTot were also highest in mild asthma/no ICS, but were not lower in SA. Instead, they persisted and were predominantly MCTC. Epithelial CPA3 and tryptase mRNA supported the immunostaining data (overall P = 0.008 and P = 0.02, respectively). Lavage PGD2 was higher in SA than in other steroid-treated groups (overall P = 0.02), whereas tryptase did not differentiate the groups. In statistical models, PGD2 and MCTC/MCTot predicted SA. Conclusions: Severe asthma is associated with a predominance of MCTC in the airway submucosa and epithelium. Activation of those MCTC may contribute to the increases in PGD2 levels. The data suggest an altered and active MC population contributes to SA pathology.

286 citations

Journal ArticleDOI
TL;DR: This month's Special Feature presented a set of five articles that constituted a Commentary on the fundamentals and mechanism of electrospray ionization (ESI), which produced some lively discussion among the authors on the role of electrochemistry in ESI.
Abstract: Editorial Comment Last month we presented, as a Special Feature, a set of five articles that constituted a Commentary on the fundamentals and mechanism of electrospray ionization (ESI). These articles produced some lively discussion among the authors on the role of electrochemistry in ESI. Six authors participated in a detailed exchange of views on this topic, the final results of which constitute this month's Special Feature. We particularly hope that younger scientists will find value in this month's Special Feature, not only for the science that it teaches but also what it reveals about the processes by which scientific conclusions are drawn. To a degree, the contributions part the curtains on these processes and show science in action. We sincerely thank the contributors to this discussion. The give and take of intellectual debate is not always easy, and to a remarkable extent this set of authors has maintained good humor and friendships, even when disagreeing strongly on substance. Graham Cooks and Richard Caprioli Copyright 2000 John Wiley & Sons, Ltd.

286 citations


Authors

Showing all 24085 results

NameH-indexPapersCitations
Ronald C. Kessler2741332328983
Carlo M. Croce1981135189007
Nicholas G. Martin1921770161952
Michael Rutter188676151592
Kenneth S. Kendler1771327142251
Bernhard O. Palsson14783185051
Thomas J. Smith1401775113919
Ming T. Tsuang14088573865
Patrick F. Sullivan13359492298
Martin B. Keller13154165069
Michael E. Thase13192375995
Benjamin F. Cravatt13166661932
Jian Zhou128300791402
Rena R. Wing12864967360
Linda R. Watkins12751956454
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202395
2022395
20213,658
20203,437
20193,039
20182,758