Institution
Virginia Commonwealth University
Education•Richmond, Virginia, United States•
About: Virginia Commonwealth University is a education organization based out in Richmond, Virginia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 23822 authors who have published 49587 publications receiving 1787046 citations. The organization is also known as: VCU.
Topics: Population, Poison control, Health care, Anxiety, Mental health
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors use stakeholder theory to explain differences in social disclosure among countries, arguing that the manner in which the role of a corporation and its stakeholders is defined in a society will affect the extent and quality of corporate social disclosure in annual reports.
575 citations
TL;DR: Cirrhosis, especially advanced disease, is associated with a decreased conversion of primary to secondary fecal BAs, which is linked to abundance of key gut microbiome taxa.
572 citations
TL;DR: Mindfulness research activity is surging within organizational science as discussed by the authors, and emerging evidence across multiple fields suggests that mindfulness is fundamentally connected to many aspects of workplace functioning, but this knowledge base has not been systematically integrated to date.
572 citations
TL;DR: For the first time, specific loci that distinguish between BD and SCZ are discovered and polygenic components underlying multiple symptom dimensions are identified that point to the utility of genetics to inform symptomology and potential treatment.
569 citations
TL;DR: Adoptive T cell therapy induced complete and durable remission in a patient with refractory metastatic breast cancer, providing proof of principle for this approach in breast cancer therapy.
Abstract: Immunotherapy using either checkpoint blockade or the adoptive transfer of antitumor lymphocytes has shown effectiveness in treating cancers with high levels of somatic mutations—such as melanoma, smoking-induced lung cancers and bladder cancer—with little effect in other common epithelial cancers that have lower mutation rates, such as those arising in the gastrointestinal tract, breast and ovary1–7. Adoptive transfer of autologous lymphocytes that specifically target proteins encoded by somatically mutated genes has mediated substantial objective clinical regressions in patients with metastatic bile duct, colon and cervical cancers8–11. We present a patient with chemorefractory hormone receptor (HR)-positive metastatic breast cancer who was treated with tumor-infiltrating lymphocytes (TILs) reactive against mutant versions of four proteins—SLC3A2, KIAA0368, CADPS2 and CTSB. Adoptive transfer of these mutant-protein-specific TILs in conjunction with interleukin (IL)-2 and checkpoint blockade mediated the complete durable regression of metastatic breast cancer, which is now ongoing for >22 months, and it represents a new immunotherapy approach for the treatment of these patients.
569 citations
Authors
Showing all 24085 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Ronald C. Kessler | 274 | 1332 | 328983 |
| Carlo M. Croce | 198 | 1135 | 189007 |
| Nicholas G. Martin | 192 | 1770 | 161952 |
| Michael Rutter | 188 | 676 | 151592 |
| Kenneth S. Kendler | 177 | 1327 | 142251 |
| Bernhard O. Palsson | 147 | 831 | 85051 |
| Thomas J. Smith | 140 | 1775 | 113919 |
| Ming T. Tsuang | 140 | 885 | 73865 |
| Patrick F. Sullivan | 133 | 594 | 92298 |
| Martin B. Keller | 131 | 541 | 65069 |
| Michael E. Thase | 131 | 923 | 75995 |
| Benjamin F. Cravatt | 131 | 666 | 61932 |
| Jian Zhou | 128 | 3007 | 91402 |
| Rena R. Wing | 128 | 649 | 67360 |
| Linda R. Watkins | 127 | 519 | 56454 |