Institution
Wadsworth Center
Facility•Albany, New York, United States•
About: Wadsworth Center is a facility organization based out in Albany, New York, United States. It is known for research contribution in the topics: Gene & RNA. The organization has 933 authors who have published 1190 publications receiving 89140 citations.
Topics: Gene, RNA, Virus, Population, Microtubule
Papers published on a yearly basis
Papers
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Centers for Disease Control and Prevention1, National Institutes of Health2, University of Cambridge3, Erasmus University Rotterdam4, Naval Medical Center San Diego5, Arizona State University6, Colorado Department of Public Health and Environment7, Oklahoma State Department of Health8, Wadsworth Center9, Ohio Department of Health10, South Carolina Department of Health and Environmental Control11, Dallas County12, Baylor College of Medicine13, San Diego State University14, Centra15, California Health and Human Services Agency16, Marshfield Clinic17, Michigan Department of Community Health18
TL;DR: The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period as mentioned in this paper.
Abstract: Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).
2,393 citations
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TL;DR: Novel features are a suite of operations relating to the determination, modeling, and correction of the contrast transfer function and the availability of the entire documentation in hypertext format.
2,117 citations
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TL;DR: The data suggest that Aurora B is required to generate unattached kinetochores on monooriented chromosomes, which in turn could promote bipolar attachment as well as maintain checkpoint signaling.
Abstract: The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle. We have identified the small molecule Hesperadin as an inhibitor of chromosome alignment and segregation. Our data imply that Hesperadin causes this phenotype by inhibiting the function of the mitotic kinase Aurora B. Mammalian cells treated with Hesperadin enter anaphase in the presence of numerous monooriented chromosomes, many of which may have both sister kinetochores attached to one spindle pole (syntelic attachment). Hesperadin also causes cells arrested by taxol or monastrol to enter anaphase within <1 h, whereas cells in nocodazole stay arrested for 3–5 h. Together, our data suggest that Aurora B is required to generate unattached kinetochores on monooriented chromosomes, which in turn could promote bipolar attachment as well as maintain checkpoint signaling.
1,236 citations
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TL;DR: An unexpected dependence of cell function and survival is revealed on the maintenance of proper spacing between the ER and mitochondria, which makes mitochondria prone to Ca2+ overloading and ensuing permeability transition.
Abstract: The role of mitochondria in cell metabolism and survival is controlled by calcium signals that are commonly transmitted at the close associations between mitochondria and endoplasmic reticulum (ER). However, the physical linkage of the ER–mitochondria interface and its relevance for cell function remains elusive. We show by electron tomography that ER and mitochondria are adjoined by tethers that are ∼10 nm at the smooth ER and ∼25 nm at the rough ER. Limited proteolysis separates ER from mitochondria, whereas expression of a short “synthetic linker” (<5 nm) leads to tightening of the associations. Although normal connections are necessary and sufficient for proper propagation of ER-derived calcium signals to the mitochondria, tightened connections, synthetic or naturally observed under apoptosis-inducing conditions, make mitochondria prone to Ca2+ overloading and ensuing permeability transition. These results reveal an unexpected dependence of cell function and survival on the maintenance of proper spacing between the ER and mitochondria.
1,144 citations
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TL;DR: It is found that the "BH3-only" molecule tBID induces a striking remodeling of mitochondrial structure with mobilization of the cytochrome c stores in cristae, independent of BAK, but is inhibited by CsA.
928 citations
Authors
Showing all 937 results
Name | H-index | Papers | Citations |
---|---|---|---|
Stephen G. Waxman | 130 | 836 | 60119 |
Kurunthachalam Kannan | 126 | 820 | 59886 |
Arturo Casadevall | 120 | 980 | 55001 |
Thomas J. Ryan | 116 | 675 | 67462 |
Allan S. Jaffe | 113 | 677 | 65052 |
Edward D. Salmon | 106 | 245 | 34558 |
Burton E. Sobel | 105 | 536 | 60441 |
Asrar B. Malik | 103 | 527 | 35994 |
Joachim Frank | 103 | 473 | 39475 |
Joe G.N. Garcia | 99 | 631 | 35913 |
Pei Yong Shi | 91 | 430 | 28152 |
Gerald E. Loeb | 90 | 426 | 24568 |
Jonathan R. Wolpaw | 85 | 256 | 42477 |
Sarah Rowland-Jones | 80 | 430 | 32262 |
David O. Carpenter | 80 | 505 | 51473 |