scispace - formally typeset
Search or ask a question
Institution

Wageningen University and Research Centre

EducationWageningen, Netherlands
About: Wageningen University and Research Centre is a education organization based out in Wageningen, Netherlands. It is known for research contribution in the topics: Population & Sustainability. The organization has 23474 authors who have published 54833 publications receiving 2608897 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: An updated evolutionary classification of CRISPR–Cas systems and cas genes is provided, with an emphasis on the major developments that have occurred since the publication of the latest classification, in 2015, which includes 2 classes, 6 types and 33 subtypes.
Abstract: The number and diversity of known CRISPR-Cas systems have substantially increased in recent years. Here, we provide an updated evolutionary classification of CRISPR-Cas systems and cas genes, with an emphasis on the major developments that have occurred since the publication of the latest classification, in 2015. The new classification includes 2 classes, 6 types and 33 subtypes, compared with 5 types and 16 subtypes in 2015. A key development is the ongoing discovery of multiple, novel class 2 CRISPR-Cas systems, which now include 3 types and 17 subtypes. A second major novelty is the discovery of numerous derived CRISPR-Cas variants, often associated with mobile genetic elements that lack the nucleases required for interference. Some of these variants are involved in RNA-guided transposition, whereas others are predicted to perform functions distinct from adaptive immunity that remain to be characterized experimentally. The third highlight is the discovery of numerous families of ancillary CRISPR-linked genes, often implicated in signal transduction. Together, these findings substantially clarify the functional diversity and evolutionary history of CRISPR-Cas.

1,153 citations

Journal ArticleDOI
TL;DR: This article used repeat photography, long-term ecological monitoring and dendrochronology to document shrub expansion in arctic, high-latitude and alpine tundra.
Abstract: Recent research using repeat photography, long-term ecological monitoring and dendrochronology has documented shrub expansion in arctic, high-latitude and alpine tundra

1,153 citations

Journal ArticleDOI
TL;DR: More high quality data is needed on the occurrence of microplastics in drinking water, to better understand potential exposure and to inform human health risk assessments, and there is a significant need to improve quality assurance ofmicroplastic sampling and analysis in water samples.

1,148 citations

Journal ArticleDOI
TL;DR: A review of the research designed to lead to an increased understanding of the chemistry of the Maillard reaction, based on recent developments, and its influence on food properties like color, flavour and nutritional value is given in this paper.
Abstract: This paper reviews some of the research designed to lead to an increased understanding of the chemistry of the Maillard reaction, based on recent developments, and its influence on food properties like colour, flavour and nutritional value A critical analysis is given on how quality attributes associated with Maillard reaction can be predicted and controlled by kinetic modelling Multiresponse modelling (taking more than one reactant and product into consideration in the modelling process) is a powerful tool to model complicated consecutive and parallel reactions, like the Maillard reaction Such a multiresponse approach provides a major guidance in understanding the reaction mechanism An illustrative example is given

1,147 citations


Authors

Showing all 23851 results

NameH-indexPapersCitations
Walter C. Willett3342399413322
Albert Hofman2672530321405
Frank B. Hu2501675253464
Willem M. de Vos14867088146
Willy Verstraete13992076659
Jonathan D. G. Jones12941780908
Bert Brunekreef12480681938
Pedro W. Crous11580951925
Marten Scheffer11135073789
Wim E. Hennink11060049940
Daan Kromhout10845355551
Peter H. Verburg10746434254
Marcel Dicke10761342959
Vincent W. V. Jaddoe106100844269
Hao Wu10566942607
Network Information
Related Institutions (5)
Institut national de la recherche agronomique
68.3K papers, 3.2M citations

96% related

University of Georgia
93.6K papers, 3.7M citations

91% related

Commonwealth Scientific and Industrial Research Organisation
79.9K papers, 3.3M citations

90% related

Ghent University
111K papers, 3.7M citations

90% related

Spanish National Research Council
220.4K papers, 7.6M citations

90% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023278
2022861
20214,144
20203,722
20193,443
20183,226