Institution
Wageningen University and Research Centre
Education•Wageningen, Netherlands•
About: Wageningen University and Research Centre is a education organization based out in Wageningen, Netherlands. It is known for research contribution in the topics: Population & Sustainability. The organization has 23474 authors who have published 54833 publications receiving 2608897 citations.
Topics: Population, Sustainability, Agriculture, Climate change, Gene
Papers published on a yearly basis
Papers
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TL;DR: The authors evaluate the empirical basis for the so-called resource curse and find that, despite the topic's popularity in economics and political science research, this apparent paradox may be a red herring.
966 citations
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TL;DR: Attention is paid to mobile genetic elements such as plasmids, transposons, and integrons, which are associated with AR genes, and involved in the dispersal of antimicrobial determinants between different bacteria.
Abstract: In this review an overview is given on antibiotic resistance (AR) mechanisms with special attentions to the AR genes described so far preceded by a short introduction on the discovery and mode of action of the different classes of antibiotics. As this review is only dealing with acquired resistance, attention is also paid to mobile genetic elements such as plasmids, transposons, and integrons, which are associated with AR genes, and involved in the dispersal of antimicrobial determinants between different bacteria.
965 citations
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TL;DR: The hypothesis that impaired folate metabolism, resulting in high homocysteine levels, is causally related to increased risk of CHD is supported, particularly in the setting of low folate status.
Abstract: ContextIn observational studies, individuals with elevated levels of plasma
homocysteine tend to have moderately increased risk of coronary heart disease
(CHD). The MTHFR 677C→T polymorphism is a genetic
alteration in an enzyme involved in folate metabolism that causes elevated
homocysteine concentrations, but its relevance to risk of CHD is uncertain.ObjectiveTo assess the relation of MTHFR 677C→T
polymorphism and risk of CHD by conducting a meta-analysis of individual participant
data from all case-control observational studies with data on this polymorphism
and risk of CHD.Data SourcesStudies were identified by searches of the electronic literature (MEDLINE
and Current Contents) for relevant reports published before June 2001 (using
the search terms MTHFR and coronary
heart disease), hand searches of reference lists of original studies
and review articles (including meta-analyses) on this topic, and contact with
investigators in the field.Study SelectionStudies were included if they had data on the MTHFR 677C→T genotype and a case-control design (retrospective or nested
case-control) and involved CHD as an end point. Data were obtained from 40
(34 published and 6 unpublished) observational studies involving a total of
11 162 cases and 12 758 controls.Data ExtractionData were collected on MTHFR 677C→T genotype,
case-control status, and plasma levels of homocysteine, folate, and other
cardiovascular risk factors. Data were checked for consistency with the published
article or with information provided by the investigators and converted into
a standard format for incorporation into a central database. Combined odds
ratios (ORs) for the association between the MTHFR 677C→T
polymorphism and CHD were assessed by logistic regression.Data SynthesisIndividuals with the MTHFR 677 TT genotype
had a 16% (OR, 1.16; 95% confidence interval [CI], 1.05-1.28) higher odds
of CHD compared with individuals with the CC genotype. There was significant
heterogeneity between the results obtained in European populations (OR, 1.14;
95% CI, 1.01-1.28) compared with North American populations (OR, 0.87; 95%
CI, 0.73-1.05), which might largely be explained by interaction between the MTHFR 677C→T polymorphism and folate status.ConclusionsIndividuals with the MTHFR 677 TT genotype
had a significantly higher risk of CHD, particularly in the setting of low
folate status. These results support the hypothesis that impaired folate metabolism,
resulting in high homocysteine levels, is causally related to increased risk
of CHD.
959 citations
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Norwegian Water Resources and Energy Directorate1, International Livestock Research Institute2, Potsdam Institute for Climate Impact Research3, Wageningen University and Research Centre4, University of Kassel5, National Institute for Environmental Studies6, Max Planck Society7, City College of New York8, Utrecht University9, University of Bonn10
TL;DR: The results indicate that direct human impacts on the water cycle in some regions, e.g., parts of Asia and in the western United States, are of the same order of magnitude, or even exceed impacts to be expected for moderate levels of global warming (+2 K).
Abstract: Humans directly change the dynamics of the water cycle through dams constructed for water storage, and through water withdrawals for industrial, agricultural, or domestic purposes. Climate change is expected to additionally affect water supply and demand. Here, analyses of climate change and direct human impacts on the terrestrial water cycle are presented and compared using a multimodel approach. Seven global hydrological models have been forced with multiple climate projections, and with and without taking into account impacts of human interventions such as dams and water withdrawals on the hydrological cycle. Model results are analyzed for different levels of global warming, allowing for analyses in line with temperature targets for climate change mitigation. The results indicate that direct human impacts on the water cycle in some regions, e.g., parts of Asia and in the western United States, are of the same order of magnitude, or even exceed impacts to be expected for moderate levels of global warming (+2 K). Despite some spread in model projections, irrigation water consumption is generally projected to increase with higher global mean temperatures. Irrigation water scarcity is particularly large in parts of southern and eastern Asia, and is expected to become even larger in the future.
953 citations
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TL;DR: In this paper, a methodological framework for spatial prediction based on regression-kriging is described and compared with ordinary kriging and plain regression, which can adopt both continuous and categorical soil variables in a semi-automated or automated manner.
946 citations
Authors
Showing all 23851 results
Name | H-index | Papers | Citations |
---|---|---|---|
Walter C. Willett | 334 | 2399 | 413322 |
Albert Hofman | 267 | 2530 | 321405 |
Frank B. Hu | 250 | 1675 | 253464 |
Willem M. de Vos | 148 | 670 | 88146 |
Willy Verstraete | 139 | 920 | 76659 |
Jonathan D. G. Jones | 129 | 417 | 80908 |
Bert Brunekreef | 124 | 806 | 81938 |
Pedro W. Crous | 115 | 809 | 51925 |
Marten Scheffer | 111 | 350 | 73789 |
Wim E. Hennink | 110 | 600 | 49940 |
Daan Kromhout | 108 | 453 | 55551 |
Peter H. Verburg | 107 | 464 | 34254 |
Marcel Dicke | 107 | 613 | 42959 |
Vincent W. V. Jaddoe | 106 | 1008 | 44269 |
Hao Wu | 105 | 669 | 42607 |