Institution
Wageningen University and Research Centre
Education•Wageningen, Netherlands•
About: Wageningen University and Research Centre is a education organization based out in Wageningen, Netherlands. It is known for research contribution in the topics: Population & Sustainability. The organization has 23474 authors who have published 54833 publications receiving 2608897 citations.
Topics: Population, Sustainability, Agriculture, Climate change, Gene
Papers published on a yearly basis
Papers
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TL;DR: The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls.
Abstract: The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls. In the first phase of the 1000 bull genomes project, we sequenced the whole genomes of 234 cattle to an average of 8.3-fold coverage. This sequencing includes data for 129 individuals from the global Holstein-Friesian population, 43 individuals from the Fleckvieh breed and 15 individuals from the Jersey breed. We identified a total of 28.3 million variants, with an average of 1.44 heterozygous sites per kilobase for each individual. We demonstrate the use of this database in identifying a recessive mutation underlying embryonic death and a dominant mutation underlying lethal chrondrodysplasia. We also performed genome-wide association studies for milk production and curly coat, using imputed sequence variants, and identified variants associated with these traits in cattle.
690 citations
TL;DR: Folic acid supplementation for 3 years significantly improved domains of cognitive function that tend to decline with age, particularly in memory and sensorimotor speed.
685 citations
Haidong Wang1, Chelsea A. Liddell1, Matthew M Coates1, Meghan D. Mooney1 +228 more•Institutions (123)
TL;DR: Decreases since 2000 in under-5 mortality rates are accelerating in many developing countries, especially in sub-Saharan Africa, and rising income per person and maternal education and changes in secular trends led to 4·2 million fewer deaths.
684 citations
TL;DR: In this paper, the development of proper decision-support systems for implementing precision decisions remains a major stumbling block to adoption of precision agriculture and other critical research issues are discussed, such as insufficient recognition of temporal variation, lack of whole-farm focus, crop quality assessment methods, product tracking and environmental auditing.
Abstract: Precision Agriculture is advancing but not as fast as predicted 5 years ago. The development of proper decision-support systems for implementing precision decisions remains a major stumbling block to adoption. Other critical research issues are discussed, namely, insufficient recognition of temporal variation, lack of whole-farm focus, crop quality assessment methods, product tracking and environmental auditing. A generic research programme for precision agriculture is presented. A typology of agriculture countries is introduced and the potential of each type for precision agriculture discussed.
683 citations
Wageningen University and Research Centre1, Ludwig Maximilian University of Munich2, Yale University3, University of Texas at Austin4, Santa Fe Institute5, National Center for Genome Resources6, University of California, San Diego7, Washington University in St. Louis8, Spanish National Research Council9, North Carolina State University10, Florida State University11, Harvard University12, Michigan State University13, University of Washington14, University of New Mexico15, University of British Columbia16
TL;DR: This work focuses on the first kind of robustness—genetic robustness)—and survey three growing avenues of research: measuring genetic robustness in nature and in the laboratory; understanding the evolution of genetic robusts; and exploring the implications of genetic resilientness for future evolution.
Abstract: Robustness is the invariance of phenotypes in the face of perturbation. The robustness of phenotypes appears at various levels of biological organization, including gene expression, protein folding, metabolic flux, physiological homeostasis, development, and even organismal fitness. The mechanisms underlying robustness are diverse, ranging from thermodynamic stability at the RNA and protein level to behavior at the organismal level. Phenotypes can be robust either against heritable perturbations (e.g., mutations) or nonheritable perturbations (e.g., the weather). Here we primarily focus on the first kind of robustness-genetic robustness-and survey three growing avenues of research: (1) measuring genetic robustness in nature and in the laboratory; (2) understanding the evolution of genetic robustness; and (3) exploring the implications of genetic robustness for future evolution.
681 citations
Authors
Showing all 23851 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Walter C. Willett | 334 | 2399 | 413322 |
| Albert Hofman | 267 | 2530 | 321405 |
| Frank B. Hu | 250 | 1675 | 253464 |
| Willem M. de Vos | 148 | 670 | 88146 |
| Willy Verstraete | 139 | 920 | 76659 |
| Jonathan D. G. Jones | 129 | 417 | 80908 |
| Bert Brunekreef | 124 | 806 | 81938 |
| Pedro W. Crous | 115 | 809 | 51925 |
| Marten Scheffer | 111 | 350 | 73789 |
| Wim E. Hennink | 110 | 600 | 49940 |
| Daan Kromhout | 108 | 453 | 55551 |
| Peter H. Verburg | 107 | 464 | 34254 |
| Marcel Dicke | 107 | 613 | 42959 |
| Vincent W. V. Jaddoe | 106 | 1008 | 44269 |
| Hao Wu | 105 | 669 | 42607 |