Institution
Walter Reed Army Medical Center
About: Walter Reed Army Medical Center is a based out in . It is known for research contribution in the topics: Population & Poison control. The organization has 5680 authors who have published 6458 publications receiving 262894 citations. The organization is also known as: Walter Reed Hospital.
Topics: Population, Poison control, Prostate cancer, Cancer, Transplantation
Papers published on a yearly basis
Papers
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Oregon Health & Science University1, University of Washington2, University at Buffalo3, University of Michigan4, University of California, San Diego5, University of Iowa Hospitals and Clinics6, University of Cincinnati7, United States Department of Veterans Affairs8, Harvard University9, United States Department of the Army10, Walter Reed Army Medical Center11, University of Connecticut12, University of Colorado Denver13, Johns Hopkins University14, Veterans Health Administration15, Boston Children's Hospital16, University of Iowa17, University of Texas at Austin18, Virginia Mason Medical Center19, Thomas Jefferson University20, Seattle Children's21, Children's Hospital of Wisconsin22
TL;DR: The American Pain Society, with input from the American Society of Anesthesiologists, developed a clinical practice guideline to promote evidence-based, effective, and safer postoperative pain management in children and adults.
1,806 citations
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TL;DR: In primary cultures of olfactory neurons, zinc protoporphyrin-9, a potent selective inhibitor of heme oxygenase, depletes endogenous guanosine 3',5'-monophosphate (cGMP), suggesting that carbon monoxide may be a physiologic regulator of cGMP.
Abstract: Carbon monoxide, an activator of guanylyl cyclase, is formed by the action of the enzyme heme oxygenase. By in situ hybridization in brain slices, discrete neuronal localization of messenger RNA for the constitutive form of heme oxygenase throughout the brain has been demonstrated. This localization is essentially the same as that for soluble guanylyl cyclase messenger RNA. In primary cultures of olfactory neurons, zinc protoporphyrin-9, a potent selective inhibitor of heme oxygenase, depletes endogenous guanosine 3',5'-monophosphate (cGMP). Thus, carbon monoxide, like nitric oxide, may be a physiologic regulator of cGMP. These findings, together with the neuronal localizations of heme oxygenase, suggest that carbon monoxide may function as a neurotransmitter.
1,509 citations
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TL;DR: Evidence-based clinical guidelines for the management of thyrotoxicosis are described that would be useful to generalist and subspeciality physicians and others providing care for patients with this condition.
1,164 citations
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TL;DR: Hypersensitivity reactions to taxol have been one of the toxicities observed with administration of this drug and guidelines are provided to prevent or minimize such toxicity and treat reactions if they still occur.
Abstract: Taxol is an antitumor agent in clinical trial that has been shown to have activity against advanced ovarian carcinoma and melanoma. Hypersensitivity reactions (HSRs) have been one of the toxicities observed with administration of this drug. Of 301 patients treated, 32 patients have had definite (27 patients) or possible (five patients) hypersensitivity reactions to taxol. All but one patient had the reaction from the first or second exposure to this agent. Reactions occurred at a variety of doses and were characterized most frequently by dyspnea, hypotension, bronchospasm, urticaria, and erythematous rashes. Thirteen (41%) patients had received premedication designed to prevent such toxicity; nevertheless, they sustained HSRs. Prolonging the drug infusion appears to have somewhat reduced, but not obviated, the risk of HSRs. The cause (taxol itself or its excipient Cremophor EL; Badische Anilin und Soda-Fabrik AG [BASF], Ludwigshafen, Federal Republic of Germany) and the mechanism of these reactions to taxol are unknown. We provide guidelines to prevent or minimize such toxicity and treat reactions if they still occur.
1,123 citations
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TL;DR: There was no difference in the incidence of rebleeding or death regardless of presentation with or without evidence of hemorrhage, and the combined rate of major morbidity and mortality remained essentially constant over the entire period of the study.
Abstract: ✓ The authors have updated a series of 166 prospectively followed unoperated symptomatic patients with arteriovenous malformations (AVM's) of the brain. Follow-up data were obtained for 160 (96%) of the original population, with a mean follow-up period of 23.7 years. The rate of major rebleeding was 4.0% per year, and the mortality rate was 1.0% per year. At follow-up review, 23% of the series were dead from AVM hemorrhage. The combined rate of major morbidity and mortality was 2.7% per year. These annual rates remained essentially constant over the entire period of the study. There was no difference in the incidence of rebleeding or death regardless of presentation with or without evidence of hemorrhage. The mean interval between initial presentation and subsequent hemorrhage was 7.7 years.
1,037 citations
Authors
Showing all 5680 results
Name | H-index | Papers | Citations |
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Rob Knight | 201 | 1061 | 253207 |
Anthony S. Fauci | 185 | 960 | 133535 |
George F. Koob | 171 | 935 | 112521 |
Murray F. Brennan | 161 | 925 | 97087 |
Barton F. Haynes | 144 | 911 | 79014 |
Jonathan I. Epstein | 138 | 1121 | 80975 |
Thomas A. Waldmann | 126 | 611 | 58309 |
John C. Byrd | 121 | 1196 | 72930 |
M. Eric Gershwin | 116 | 1070 | 51902 |
Joseph E. Parisi | 115 | 487 | 49599 |
Marin H. Kollef | 113 | 631 | 49283 |
William H. Westra | 110 | 441 | 52448 |
Jordan Grafman | 109 | 546 | 54241 |
Stephen E. Epstein | 108 | 384 | 39340 |
Kurt Kroenke | 107 | 478 | 110326 |