Waseda University

About: Waseda University is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Large Hadron Collider & Catalysis. The organization has 24220 authors who have published 46859 publications receiving 837855 citations. The organization is also known as: Waseda daigaku & Sōdai.

Alterations in RFamide-Related Peptide Expression Are Coordinated with the Preovulatory Luteinizing Hormone Surge

Abstract: The preovulatory LH surge is triggered when the circadian pacemaker, the bilateral suprachiasmatic nucleus (SCN), stimulates the GnRH system in the presence of high estrogen concentrations (positive feedback). Importantly, during the remainder of the estrous cycle, estradiol inhibits LH release via negative feedback. We have recently documented the presence of a novel mammalian RFamide-related peptide (RFRP), a putative gonadotropin-inhibitory hormone (GnIH), that presumably acts upstream of GnRH to modulate the negative feedback effects of estrogen. The present series of studies used female Syrian hamsters to examine the possibility that, in addition to driving the LH surge positively, the SCN concomitantly coordinates the removal of steroid-mediated RFRP inhibition of the gonadotropic axis to permit the surge. We found that the SCN forms close appositions with RFRP cells, suggesting the possibility for direct temporal control of RFRP activity. During the time of the LH surge, immediate-early gene expression is reduced in RFRP cells, and this temporal regulation is estrogen dependent. To determine whether projections from the SCN regulate the timed reduction in activation of the RFRP system, we exploited the phenomenon of splitting. In split animals in which the SCN are active in antiphase, activation of the RFRP system is asymmetrical. Importantly, this asymmetry is opposite to the state of the GnRH system. Together, these findings point to novel circadian control of the RFRP system and potential participation in the circuitry controlling ovulatory function.

The fluctuation theorem for currents in open quantum systems

Abstract: A quantum-mechanical framework is set up to describe the full counting statistics of particles flowing between reservoirs in an open system under time-dependent driving. A symmetry relation is obtained, which is the consequence of microreversibility for the probability of the nonequilibrium work and the transfer of particles and energy between the reservoirs. In some appropriate long-time limit, the symmetry relation leads to a steady-state quantum fluctuation theorem for the currents between the reservoirs. On this basis, relationships are deduced which extend the Onsager–Casimir reciprocity relations to the nonlinear response coefficients.

Recent Advances in the Catalytic Pauson–Khand-Type Reaction

Abstract: The Pauson-Khand-type reaction is for- mally a (2 + 2 + 1) cycloaddition involving an alkyne, an alkene and carbon monoxide catalyzed or mediat- ed by transition metal complexes. This review focus- es on the catalytic reaction and describes the recent research on the Pauson-Khand-type reaction.

Exchange Rate, Exchange Rate Volatility and Foreign Direct Investment

Abstract: In the light of the importance of foreign direct investment (FDI) for the promotion of economic development, this paper examines the impact of the changes in the real exchange rate and its volatility on FDI. Examining Japan's FDI by industries, we found that the depreciation of the currency of the host country attracted FDI, while the high volatility of the exchange rate discouraged FDI. Our results suggest the need to avoid over-valuation of the exchange rate and to maintain stable but flexible exchange rate in order to attract FDI.