Waseda University

About: Waseda University is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Catalysis & Large Hadron Collider. The organization has 24220 authors who have published 46859 publications receiving 837855 citations. The organization is also known as: Waseda daigaku & Sōdai.

CNN cloning template: connected component detector

Abstract: An extremely simple cloning template for a cellular neural network (CNN) is presented that is capable of detecting the number of connected components of a vector in (+1, -1)/sup N/. By exploiting this capability, an architecture for a handwritten character recognition system was obtained. A preliminary test result (100 handwritten numbers, 0-9) shows 94-100% correct recognition rates. >

Precise measurement of the W-boson mass with the CDF II detector

Abstract: We have measured the W-boson mass M{sub W} using data corresponding to 2.2 fb{sup -1} of integrated luminosity collected in p{bar p} collisions at {radical}s = 1.96 TeV with the CDF II detector at the Fermilab Tevatron collider. Samples consisting of 470 126 W {yields} e{nu} candidates and 624 708 W {yields} {mu}{nu} candidates yield the measurement M{sub W} = 80 387 {+-} 12{sub stat} {+-} 15{sub syst} = 80 387 {+-} 19 MeV/c{sup 2}. This is the most precise measurement of the W-boson mass to date and significantly exceeds the precision of all previous measurements combined.

Transient Brain Ischaemia Provokes Ca2+, PIP2 and Calpain Responses Prior to Delayed Neuronal Death in Monkeys

Abstract: To clarify the mechanism of postischaemic delayed cornu Ammonis (CA)-1 neuronal death, we studied correlations among calpain activation and its subcellular localization, the immunoreactivity of phosphatidylinositol 4,5-bisphosphate (PIP2) and Ca2+ mobilization in the monkey hippocampus by two independent experimental approaches: in vivo transient brain ischaemia and in vitro hypoxia-hypoglycaemia of hippocampal acute slices. The CA-1 sector undergoing 20 min of ischaemia in vivo showed microscopically a small number of neuronal deaths on day 1 and almost global neuronal loss on day 5 after ischaemia. Immediately after ischaemia, CA-1 neurons ultrastructurally showed vacuolation and/or disruption of the lysosomes. Western blotting using antibodies against inactivated or activated mu-calpain demonstrated mu-calpain activation specifically in the CA-1 sector immediately after ischaemia. This finding was confirmed in the perikarya of CA-1 neurons by immunohistochemistry. CA-1 neurons on day 1 showed sustained activation of mu-calpain, and increased immunostaining for inactivated and activated forms of mu- and m-calpains and for PIP2. Activated mu-calpain and PIP2 were found to be localized at the vacuolated lysosomal membrane or endoplasmic reticulum and mitochondrial membrane respectively, by immunoelectron microscopy. Calcium imaging data using hippocampal acute slices showed that hypoxia-hypoglycaemia in vitro provoked intense Ca2+ mobilization with increased PIP2 immunostaining specifically in CA-1 neurons. These data suggest that transient brain ischaemia increases intracellular Ca2+ and PIP2 breakdown, which will activate calpain proteolytic activity. Therefore, we suggest that activated calpain at the lysosomal membrane, with the possible release of biodegrading enzyme, will cause postischaemic CA-1 neuronal death.

A longitudinal study of mentor and protégé outcomes in formal mentoring relationships

Abstract: Summary This study examined relationships between mentoring functions offered and transformational leadership as a mentor outcome and affective well-being and organizational commitment as mutual outcomes for both mentors and proteges. For this examination, we conducted a longitudinal field study by using 111 matched reports from both mentors and proteges collected at three different points in time over seven months in nine Korean companies that administered a standardized formal mentoring program. Study results showed that mentoring functions assessed at Time 2 were positively associated with mentors' and proteges' post-mentoring outcomes at Time 3 after controlling for pre-mentoring initial levels of those outcomes at Time 1. Study findings also revealed that relative effects of mentoring on the mentor and protege outcomes differed by the types of mentoring functions. We discuss the theoretical, practical, and methodological implications from these results. Copyright © 2012 John Wiley & Sons, Ltd.