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Institution

Waseda University

EducationTokyo, Japan
About: Waseda University is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Large Hadron Collider & Catalysis. The organization has 24220 authors who have published 46859 publications receiving 837855 citations. The organization is also known as: Waseda daigaku & Sōdai.


Papers
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Journal ArticleDOI
TL;DR: Au@Pt nanocolloids with nanostructured dendritic Pt shells are successfully synthesized by chemically reducing both H2PtCl6 and HAuCl4 species in the presence of a low-concentration surfactant solution as mentioned in this paper.
Abstract: Au@Pt nanocolloids with nanostructured dendritic Pt shells are successfully synthesized by chemically reducing both H2PtCl6 and HAuCl4 species in the presence of a low-concentration surfactant solution. By applying an ultrasonic treatment, the particle size of the Au@Pt nanocolloids is dramatically decreased and their size distribution becomes very narrow. The difference in reduction potentials of the two soluble metal salts (Au(III) and Pt(IV) species) plays a key role in the one-step synthesis of the core−shell structure. Because of the different reduction potentials, the reduction of Au ions preferentially occurs over a short time to form the Au seeds. It is followed by overgrowth of Pt nanodendritic nanowires on the Au seeds, which is confirmed by ultraviolet−visible light absorption spectroscopy and transmission electron microscopy. Interestingly, the Pt shell thicknesses on Au cores can be easily tuned by controlling the Pt/Au molar ratios in the starting precursor solutions. Through the optimizatio...

377 citations

Journal ArticleDOI
TL;DR: Type VI 3β-hydroxyl-steroid dehydrogenase (Hsd3b6) is identified as a new hypertension risk factor in mice and placed in a pivotal position through which circadian clock malfunction is coupled to the development of hypertension.
Abstract: The circadian clock controls many aspects of human physiology, and disturbances in circadian rhythms have been linked to cardiovascular disease. Masao Doi et al. now delineate a new pathway by which the circadian clock influences hormone production and blood pressure in mice—clock genes control expression of an aldosterone biosynthetic enzyme, such that increased activity of this enzyme in mice with a disrupted circadian clock may account for the increased aldosterone levels and salt-sensitive hypertension seen in these mice.

376 citations

Journal ArticleDOI
TL;DR: In this paper, the role of hydrogen in reducing ductile crack growth resistance is attributed to the increased creation of vacancies on straining, which is supported by a recent finding of amorphisation associated with crack growth.
Abstract: Recent studies of the characteristics and mechanism of hydrogen related failure in steels are overviewed. Based on an analysis of the states of hydrogen in steels, the role of hydrogen in reducing ductile crack growth resistance is attributed to the increased creation of vacancies on straining. Cases showing the involvement of strain induced vacancies in susceptibility to fracture are presented. The function of hydrogen is ascribed to an increase in the density of vacancies and their agglomeration, rather than hydrogen itself, through interactions between vacancies and hydrogen. The newly proposed mechanism of hydrogen related failure is supported by a recent finding of amorphisation associated with crack growth.

375 citations

Journal ArticleDOI
27 Jul 2007-Cell
TL;DR: It is shown by high-speed imaging of rotation in single molecules of F(1) that phosphate release drives the last 40 degrees of the 120 degrees step, and that the 40 degrees rotation accompanies reduction of the affinity for phosphate.

375 citations

Journal ArticleDOI
TL;DR: Atelocollagen-mediated systemic administration of siRNAs such as enhancer of zeste homolog 2 and phosphoinositide 3'-hydroxykinase p110-alpha-subunit resulted in an efficient inhibition of metastatic tumor growth in bone tissues.
Abstract: Silencing of gene expression by small interfering RNAs (siRNAs) is rapidly becoming a powerful tool for genetic analysis and represents a potential strategy for therapeutic product development. However, there are no reports of systemic delivery for siRNAs toward treatment of bone-metastatic cancer. Accordingly, we report here that i.v. injection of GL3 luciferase siRNA complexed with atelocollagen showed effective reduction of luciferase expression from bone-metastatic prostate tumor cells developed in mouse thorax, jaws, and/or legs. We also show that the siRNA/atelocollagen complex can be efficiently delivered to tumors 24 h after injection and can exist intact at least for 3 days. Furthermore, atelocollagen-mediated systemic administration of siRNAs such as enhancer of zeste homolog 2 and phosphoinositide 3′-hydroxykinase p110-α-subunit, which were selected as candidate targets for inhibition of bone metastasis, resulted in an efficient inhibition of metastatic tumor growth in bone tissues. In addition, upregulation of serum IL-12 and IFN-α levels was not associated with the in vivo administration of the siRNA/atelocollagen complex. Thus, for treatment of bone metastasis of prostate cancer, an atelocollagen-mediated systemic delivery method could be a reliable and safe approach to the achievement of maximal function of siRNA.

374 citations


Authors

Showing all 24378 results

NameH-indexPapersCitations
Yusuke Nakamura1792076160313
Yoshio Bando147123480883
Charles Maguire142119795026
Kazunori Kataoka13890870412
Senta Greene134134690697
Intae Yu134137289870
Kohei Yorita131138991177
Wei Xie128128177097
Susumu Kitagawa12580969594
Leon O. Chua12282471612
Jun Kataoka12160354274
S. Youssef12068365110
Katsuhiko Mikoshiba12086662394
Yusuke Yamauchi117100051685
Teruo Okano11747647081
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202380
2022237
20212,347
20202,467
20192,367
20182,289