Showing papers by "Washington State University published in 2005"
TL;DR: The ability of an environmental factor to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology.
Abstract: Transgenerational effects of environmental toxins require either a chromosomal or epigenetic alteration in the germ line. Transient exposure of a gestating female rat during the period of gonadal sex determination to the endocrine disruptors vinclozolin (an antiandrogenic compound) or methoxychlor (an estrogenic compound) induced an adult phenotype in the F1 generation of decreased spermatogenic capacity (cell number and viability) and increased incidence of male infertility. These effects were transferred through the male germ line to nearly all males of all subsequent generations examined (that is, F1 to F4). The effects on reproduction correlate with altered DNA methylation patterns in the germ line. The ability of an environmental factor (for example, endocrine disruptor) to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology.
2,280 citations
TL;DR: In this article, a review summarizes and critiques the empirical ethical decision-making literature from 1996 to 2003, concluding that one hundred and seventy-four articles were published in top business journals during this period.
Abstract: This review summarizes and critiques the empirical ethical decision-making literature from 1996–2003. One hundred and seventy-four articles were published in top business journals during this period. Tables are included that summarize the findings by dependent variable – awareness, judgment, intent, and behavior. We compare this review with past reviews in order to draw conclusions regarding trends in the ethical decision-making literature and to surface directions for future research.
1,355 citations
TL;DR: Two families of basis sets that systematically converge towards the complete basis set (CBS) limit have been developed for the first-row transition metal elements Sc-Zn and nonrelativistic and Douglas-Kroll-Hess (-DK) relativistic are presented.
Abstract: Sequences of basis sets that systematically converge towards the complete basis set (CBS) limit have been developed for the first-row transition metal elements Sc–Zn. Two families of basis sets, nonrelativistic and Douglas-Kroll-Hess (-DK) relativistic, are presented that range in quality from triple-ζ to quintuple-ζ. Separate sets are developed for the description of valence (3d4s) electron correlation (cc-pVnZ and cc-pVnZ-DK; n=T,Q, 5) and valence plus outer-core (3s3p3d4s) correlation (cc-pwCVnZ and cc-pwCVnZ-DK; n=T,Q, 5), as well as these sets augmented by additional diffuse functions for the description of negative ions and weak interactions (aug-cc-pVnZ and aug-cc-pVnZ-DK). Extensive benchmark calculations at the coupled cluster level of theory are presented for atomic excitation energies, ionization potentials, and electron affinities, as well as molecular calculations on selected hydrides (TiH, MnH, CuH) and other diatomics (TiF, Cu2). In addition to observing systematic convergence towards the C...
1,225 citations
TL;DR: The potential of Piriformospora indica to induce resistance to fungal diseases and tolerance to salt stress in the monocotyledonous plant barley is reported on.
Abstract: Disease resistance strategies are powerful approaches to sustainable agriculture because they reduce chemical input into the environment. Recently, Piriformospora indica, a plant-root-colonizing basidiomycete fungus, has been discovered in the Indian Thar desert and was shown to provide strong growth-promoting activity during its symbiosis with a broad spectrum of plants [Verma, S. et al. (1998) Mycologia 90, 896-903]. Here, we report on the potential of P. indica to induce resistance to fungal diseases and tolerance to salt stress in the monocotyledonous plant barley. The beneficial effect on the defense status is detected in distal leaves, demonstrating a systemic induction of resistance by a root-endophytic fungus. The systemically altered “defense readiness” is associated with an elevated antioxidative capacity due to an activation of the glutathione-ascorbate cycle and results in an overall increase in grain yield. Because P. indica can be easily propagated in the absence of a host plant, we conclude that the fungus could be exploited to increase disease resistance and yield in crop plants.
1,197 citations
TL;DR: In this paper, a series of basis sets designed for valence-only and outer-core electron correlation are presented, as well as these sets augmented by additional diffuse functions for the accurate description of negative ions and weak interactions.
Abstract: Sequences of basis sets that systematically converge towards the complete basis set (CBS) limit have been developed for the coinage metals (Cu, Ag, Au) and group 12 elements (Zn, Cd, Hg). These basis sets are based on recently published small-core relativistic pseudopotentials [Figgen D, Rauhut G, Dolg M, Stoll H (2005) Chem Phys 311:227] and range in size from double- through quintuple-ζ. Series of basis sets designed for valence-only and outer-core electron correlation are presented, as well as these sets augmented by additional diffuse functions for the accurate description of negative ions and weak interactions. Selected benchmark calculations at the coupled cluster level of theory are presented for both atomic and molecular properties. The latter include the calculation of both spectroscopic and thermochemical properties of the homonuclear dimers Cu2, Ag2, and Au2, as well as the van der Waals species Zn2, Cd2, and Hg2. The CBS limit results, including the effects of core-valence correlation and spin-orbit coupling, represent some of the most accurate carried out to date and result in new recommendations for the equilibrium bond lengths of the group 12 dimers. Comparisons are also made to a limited number of all-electron Douglas–Kroll–Hess (DKH) calculations (second and third order) carried out using new correlation consistent basis sets of triple-ζ quality.
1,005 citations
TL;DR: Using a variety of approaches, researchers have begun to unravel the exquisite control mechanisms exerted by cells specialized for CaOx formation that include the machinery for uptake and accumulation of Ca, oxalic acid biosynthetic pathways, and regulation of crystal growth.
Abstract: Calcium oxalate (CaOx) crystals are distributed among all taxonomic levels of photosynthetic organisms from small algae to angiosperms and giant gymnosperms. Accumulation of crystals by these organisms can be substantial. Major functions of CaOx crystal formation in plants include high-capacity calcium (Ca) regulation and protection against herbivory. Ultrastructural and developmental analyses have demonstrated that this biomineralization process is not a simple random physical-chemical precipitation of endogenously synthesized oxalic acid and environmentally derived Ca. Instead, crystals are formed in specific shapes and sizes. Genetic regulation of CaOx formation is indicated by constancy of crystal morphology within species, cell specialization, and the remarkable coordination of crystal growth and cell expansion. Using a variety of approaches, researchers have begun to unravel the exquisite control mechanisms exerted by cells specialized for CaOx formation that include the machinery for uptake and accumulation of Ca, oxalic acid biosynthetic pathways, and regulation of crystal growth.
993 citations
TL;DR: This study demonstrates that segmental duplications define hotspots of chromosomal rearrangement, likely acting as mediators of normal variation as well as genomic disease, and suggests that the consideration of genomic architecture can significantly improve the ascertainment of large-scale rearrangements.
Abstract: The human genome contains numerous blocks of highly homologous duplicated sequence. This higher-order architecture provides a substrate for recombination and recurrent chromosomal rearrangement associated with genomic disease. However, an assessment of the role of segmental duplications in normal variation has not yet been made. On the basis of the duplication architecture of the human genome, we defined a set of 130 potential rearrangement hotspots and constructed a targeted bacterial artificial chromosome (BAC) microarray (with 2,194 BACs) to assess copy-number variation in these regions by array comparative genomic hybridization. Using our segmental duplication BAC microarray, we screened a panel of 47 normal individuals, who represented populations from four continents, and we identified 119 regions of copy-number polymorphism (CNP), 73 of which were previously unreported. We observed an equal frequency of duplications and deletions, as well as a 4-fold enrichment of CNPs within hotspot regions, compared with control BACs (P 4-fold within regions of CNP. Almost without exception, CNPs were not confined to a single population, suggesting that these either are recurrent events, having occurred independently in multiple founders, or were present in early human populations. Our study demonstrates that segmental duplications define hotspots of chromosomal rearrangement, likely acting as mediators of normal variation as well as genomic disease, and it suggests that the consideration of genomic architecture can significantly improve the ascertainment of large-scale rearrangements. Our specialized segmental duplication BAC microarray and associated database of structural polymorphisms will provide an important resource for the future characterization of human genomic disorders.
950 citations
TL;DR: This review focuses on bark defenses, a front line against organisms trying to reach the nutrient-rich phloem, and questions about their coevolution with bark beetles are discussed.
Abstract: Conifers are long-lived organisms, and part of their success is due to their potent defense mechanisms. This review focuses on bark defenses, a front line against organisms trying to reach the nutrient-rich phloem. A major breach of the bark can lead to tree death, as evidenced by the millions of trees killed every year by specialized bark-invading insects. Different defense strategies have arisen in conifer lineages, but the general strategy is one of overlapping constitutive mechanical and chemical defenses overlaid with the capacity to up-regulate additional defenses. The defense strategy incorporates a graded response from 'repel', through 'defend' and 'kill', to 'compartmentalize', depending upon the advance of the invading organism. Using a combination of toxic and polymer chemistry, anatomical structures and their placement, and inducible defenses, conifers have evolved bark defense mechanisms that work against a variety of pests. However, these can be overcome by strategies including aggregation pheromones of bark beetles and introduction of virulent phytopathogens. The defense structures and chemicals in conifer bark are reviewed and questions about their coevolution with bark beetles are discussed.
929 citations
Posted Content•
TL;DR: In this paper, the authors extend the model-free implied volatility to asset price processes with jumps and develop a simple method for implementing it using observed option prices, and perform a direct test of the informational efficiency of the option market using the model free implied volatility.
Abstract: Britten-Jones and Neuberger (2000) derived a model-free implied volatility under the diffusion assumption. In this article, we extend their model-free implied volatility to asset price processes with jumps and develop a simple method for implementing it using observed option prices. In addition, we perform a direct test of the informational efficiency of the option market using the model-free implied volatility. Our results from the Standard & Poor’s 500 index (SPX) options suggest that the model-free implied volatility subsumes all information contained in the Black-Scholes (B-S) implied volatility and past realized volatility and is a more efficient forecast for future realized volatility.
825 citations
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TL;DR: The dihydrochalcone phlorizin is a natural product and dietary constituent found in a number of fruit trees that has been used as a pharmaceutical and tool for physiology research for over 150 years.
Abstract: The dihydrochalcone phlorizin is a natural product and dietary constituent found in a number of fruit trees. It has been used as a pharmaceutical and tool for physiology research for over 150 years. Phlorizin's principal pharmacological action is to produce renal glycosuria and block intestinal glucose absorption through inhibition of the sodium-glucose symporters located in the proximal renal tubule and mucosa of the small intestine. This review covers the role phlorizin has played in the history of diabetes mellitus and its use as an agent to understand fundamental concepts in renal physiology as well as summarizes the physiology of cellular glucose transport and the pathophysiology of renal glycosuria. It reviews the biology and pathobiology of glucose transporters and discusses the medical botany of phlorizin and the potential effects of plant flavonoids, such as phlorizin, on human metabolism. Lastly, it describes the clinical pharmacology and toxicology of phlorizin, including investigational uses of phlorizin and phlorizin analogs in the treatment of diabetes, obesity, and stress hyperglycemia.
804 citations
TL;DR: A valid and reliable instrument was developed to identify feeding styles in parents of low-income minority preschoolers and found differences were found among the feeding styles on an independent measure of child's body mass index.
TL;DR: Various features that contribute to its commensal lifestyle on plants, including broad catabolic and transport capabilities for utilizing plant-derived compounds, the apparent ability to use a diversity of iron siderophores, detoxification systems to protect from oxidative stress, and the lack of a type III secretion system and toxins found in related pathogens are identified.
Abstract: Pseudomonas fluorescens Pf-5 is a plant commensal bacterium that inhabits the rhizosphere and produces secondary metabolites that suppress soilborne plant pathogens. The complete sequence of the 7.1-Mb Pf-5 genome was determined. We analyzed repeat sequences to identify genomic islands that, together with other approaches, suggested P. fluorescens Pf-5's recent lateral acquisitions include six secondary metabolite gene clusters, seven phage regions and a mobile genomic island. We identified various features that contribute to its commensal lifestyle on plants, including broad catabolic and transport capabilities for utilizing plant-derived compounds, the apparent ability to use a diversity of iron siderophores, detoxification systems to protect from oxidative stress, and the lack of a type III secretion system and toxins found in related pathogens. In addition to six known secondary metabolites produced by P. fluorescens Pf-5, three novel secondary metabolite biosynthesis gene clusters were also identified that may contribute to the biocontrol properties of P. fluorescens Pf-5.
TL;DR: The multiple cellular roles of flavonoids can reflect their chemical diversity, or might suggest the existence of cellular targets shared between many of these seemingly disparate processes.
TL;DR: A newly discovered molecular influence on implantation through the lysophosphatidic acid (LPA) receptor LPA3 is reported, and linkage between LPA signalling and prostaglandin biosynthesis is indicated.
Abstract: The molecular mechanisms affecting female reproduction, particularly therapeutically tractable ones, are incompletely understood. So the identification of a new signalling mechanism affecting fertility via embryo implantation could be important. The compound involved is lysophosphatidic acid (LPA), acting through a G protein-coupled receptor. Targeted deletion of the receptor, called LPA3, produces mice that display delayed implantation, altered implantation spacing, hypertrophic placentas and embryonic death. G protein-coupled receptors are among the most common targets of drug action, raising the possibility of developing new medicines for the treatment of infertility by targeting the LPA3 receptor. Every successful pregnancy requires proper embryo implantation. Low implantation rate is a major problem during infertility treatments using assisted reproductive technologies1. Here we report a newly discovered molecular influence on implantation through the lysophosphatidic acid (LPA) receptor LPA3 (refs 2–4). Targeted deletion of LPA3 in mice resulted in significantly reduced litter size, which could be attributed to delayed implantation and altered embryo spacing. These two events led to delayed embryonic development, hypertrophic placentas shared by multiple embryos and embryonic death. An enzyme demonstrated to influence implantation, cyclooxygenase 2 (COX2) (ref. 5), was downregulated in LPA3-deficient uteri during pre-implantation. Downregulation of COX2 led to reduced levels of prostaglandins E2 and I2 (PGE2 and PGI2), which are critical for implantation1. Exogenous administration of PGE2 or carbaprostacyclin (a stable analogue of PGI2) into LPA3-deficient female mice rescued delayed implantation but did not rescue defects in embryo spacing. These data identify LPA3 receptor-mediated signalling as having an influence on implantation, and further indicate linkage between LPA signalling and prostaglandin biosynthesis.
TL;DR: The authors applied mixed logit to combined revealed and stated preference data on commuter choices of whether to pay a toll for congestion free express travel and found that motorists exhibit high values of travel time and reliability and substantial heterogeneity in those values.
Abstract: We apply recent econometric advances to study the distribution of commuters' preferences for speedy and reliable highway travel. Our analysis applies mixed logit to combined revealed and stated preference data on commuter choices of whether to pay a toll for congestion free express travel. We find that motorists exhibit high values of travel time and reliability and substantial heterogeneity in those values. We suggest that road pricing policies designed to cater to such varying preferences can improve efficiency and reduce the disparity of welfare impacts compared with recent pricing experiments.
17 Oct 2005
TL;DR: The functions and architectures of control centers: their past, present, and likely future are reviewed.
Abstract: In this paper, we review the functions and architectures of control centers: their past, present, and likely future. The evolving changes in power system operational needs require a distributed control center that is decentralized, integrated, flexible, and open. Present-day control centers are moving in that direction with varying degrees of success. The technologies employed in today's control centers to enable them to be distributed are briefly reviewed. With the rise of the Internet age, the trend in information and communication technologies is moving toward Grid computing and Web services, or Grid services. A Grid service-based future control center is stipulated.
TL;DR: Observations suggest that a complex network of cell-cell interactions is required to control the primordial to primary follicle transition, which provides therapeutic targets to regulate ovarian function and treat ovarian disease.
Abstract: The assembly of the primordial follicles early in ovarian development and the subsequent development and transition of the primordial follicle to the primary follicle are critical processes in ovarian biology. These processes directly affect the number of oocytes available to a female throughout her reproductive life. Once the pool of primordial follicles is depleted a series of physiological changes known as menopause occur. The inappropriate coordination of these processes contributes to ovarian pathologies such as premature ovarian failure (POF) and infertility. Primordial follicle assembly and development are coordinated by locally produced paracrine and autocrine growth factors. Endocrine factors such as progesterone have also been identified that influence follicular assembly. Locally produced factors that promote the primordial to primary follicle transition include growth factors such as kit ligand (KL), leukaemia inhibitory factor (LIF), bone morphogenic proteins (BMP's), keratinocyte growth factor (KGF) and basic fibroblast growth factor (bFGF). Factors mediating both precursor theca-granulosa cell interactions and granulosa-oocyte interactions have been identified. A factor produced by preantral and antral follicles, Mullerian inhibitory substance, can act to inhibit the primordial to primary follicle transition. Observations suggest that a complex network of cell-cell interactions is required to control the primordial to primary follicle transition. Elucidation of the molecular and cellular control of primordial follicle assembly and the primordial to primary follicle transition provides therapeutic targets to regulate ovarian function and treat ovarian disease.
TL;DR: The assembly of the iron-sulphur framework of the active site of iron-only hydrogenase (the H-cluster) is reported, and it is shown that it functions as an electrocatalyst for proton reduction.
Abstract: In conventional hydrogen fuel cells the rapid interconversion of protons and electrons to hydrogen requires catalysis by expensive metals, usually platinum. In the living world enzymes catalyse this same reaction at extraordinary rates using abundant metals. Tard et al. now report the chemical synthesis of the iron–sulphur structure at the heart of the hydrogenase protein. The resulting iron–sulphur framework functions as an electrocatalyst for proton reduction, a potentially important step towards new materials to replace platinum in the anodes of fuel cells. The metal-sulphur active sites of hydrogenases catalyse hydrogen evolution or uptake at rapid rates. Understanding the structure and function of these active sites—through mechanistic studies of hydrogenases1,2,3,4, synthetic assemblies5,6,7,8,9,10,11,12 and in silico models13,14,15—will help guide the design of new materials for hydrogen production or uptake16. Here we report the assembly of the iron-sulphur framework of the active site of iron-only hydrogenase (the H-cluster), and show that it functions as an electrocatalyst for proton reduction. Through linking of a di-iron subsite to a {4Fe4S} cluster, we achieve the first synthesis of a metallosulphur cluster core involved in small-molecule catalysis. In addition to advancing our understanding of the natural biological system, the availability of an active, free-standing analogue of the H-cluster may enable us to develop useful electrocatalytic materials for application in, for example, reversible hydrogen fuel cells. (Platinum is currently the preferred electrocatalyst for such applications, but is expensive, limited in availability and, in the long term, unsustainable17.)
TL;DR: This paper will focus on the review and discussion of some of the most relevant rheological tests of current interest to the food industry in selected examples, i.e. gels and emulsions.
TL;DR: The authors investigated the effects of consumer skepticism toward advertising on responses to ads and found that more skeptical consumers like advertising less, rely on it less, attend to it less and respond more positively to emotional appeals than to informational appeals.
Abstract: Three studies investigated the effects of consumer skepticism toward advertising on responses to ads. Consumer skepticism, defined as the tendency toward disbelief of advertising claims (Obermiller and Spangenberg 1998), is measured in each study and then related to various measures of advertising response, including brand beliefs, ad attitudes, responses to informational and emotional appeals, efforts to avoid advertising, attention to ads, and reliance on ads versus other information sources. The results generally support the hypotheses that more skeptical consumers like advertising less, rely on it less, attend to it less, and respond more positively to emotional appeals than to informational appeals.
09 May 2005
TL;DR: Online demonstration of a new response-based (feedback) Wide-Area stability and voltage Control System (WACS) is described, developed as a flexible platform to prevent blackouts and facilitate electrical commerce.
Abstract: As background, we describe frequently used feedforward wide-area discontinuous power system stability controls. Then we describe online demonstration of a new response-based (feedback) Wide-Area stability and voltage Control System (WACS). The control system uses powerful discontinuous actions for power system stabilization. The control system comprises phasor measurements at many substations, fiber-optic communications, real-time deterministic computers, and transfer trip output signals to circuit breakers at many other substations and power plants. Finally, we describe future development of WACS. WACS is developed as a flexible platform to prevent blackouts and facilitate electrical commerce.
TL;DR: It is concluded that protein quality established the baseline for discrimination between dietary groupings, while other variables, such as dietary protein intake relative to animal requirements, created within-group variation.
Abstract: We tested the competing hypotheses that (1) nitrogen discrimination in mammals and birds increases with dietary nitrogen concentration or decreasing C:N ratios and, therefore, discrimination will increase with trophic level as carnivores ingest more protein than herbivores and omnivores or (2) nitrogen discrimination increases as dietary protein quality decreases and, therefore, discrimination will decrease with trophic level as carnivores ingest higher quality protein than do herbivores. Discrimination factors were summarized for five major diet groupings and 21 different species of birds and mammals. Discrimination did not differ between mammals and birds and decreased as protein quality (expressed as biological value) increased with trophic level (i.e., herbivores to carnivores). Relationships between discrimination factors and dietary nitrogen concentration or C:N ratios were either the opposite of what was hypothesized or non-significant. Dietary protein quality accounted for 72% of the variation in discrimination factors across diet groupings. We concluded that protein quality established the baseline for discrimination between dietary groupings, while other variables, such as dietary protein intake relative to animal requirements, created within-group variation. We caution about the care needed in developing studies to understand variation in discrimination and subsequently applying those discrimination factors to estimate assimilated diets of wild animals.
TL;DR: In this article, the authors presented the most comprehensive, quantitative analyses of z~6 galaxies yet and provided optimal measures of the UV luminosity function (LF) and luminosity density at z ~6, and their evolution to z~3.
Abstract: We have detected 506 i-dropouts (z~6 galaxies) in deep, wide-area HST ACS fields: HUDF, enhanced GOODS, and HUDF-Parallel ACS fields (HUDF-Ps). The contamination levels are =92% are at z~6). With these samples, we present the most comprehensive, quantitative analyses of z~6 galaxies yet and provide optimal measures of the UV luminosity function (LF) and luminosity density at z~6, and their evolution to z~3. We redetermine the size and color evolution from z~6 to z~3. Field-to-field variations (cosmic variance), completeness, flux, and contamination corrections are modelled systematically and quantitatively. After corrections, we derive a rest-frame continuum UV (~1350 A) LF at z~6 that extends to M_{1350,AB} ~ -17.5 (0.04L*(z=3)). There is strong evidence for evolution of the LF between z~6 and z~3, most likely through a brightening (0.6+/-0.2 mag) of M* (at 99.7% confidence) though the degree depends upon the faint-end slope. As expected from hierarchical models, the most luminous galaxies are deficient at z~6. Density evolution (phi*) is ruled out at >99.99% confidence. Despite large changes in the LF, the luminosity density at z~6 is similar (0.82+/-0.21x) to that at z~3. Changes in the mean UV color of galaxies from z~6 to z~3 suggest an evolution in dust content, indicating the true evolution is substantially larger: at z~6 the star formation rate density is just ~30% of the z~3 value. Our UV luminosity function is consistent with z~6 galaxies providing the necessary UV flux to reionize the universe.
TL;DR: A system-level testing technique that combines test generation based on finite state machines with constraints with the goal of reducing the state space explosion otherwise inherent in using FSMs is proposed.
Abstract: Researchers and practitioners are still trying to find effective ways to model and test Web applications This paper proposes a system-level testing technique that combines test generation based on finite state machines with constraints We use a hierarchical approach to model potentially large Web applications The approach builds hierarchies of Finite State Machines (FSMs) that model subsystems of the Web applications, and then generates test requirements as subsequences of states in the FSMs These subsequences are then combined and refined to form complete executable tests The constraints are used to select a reduced set of inputs with the goal of reducing the state space explosion otherwise inherent in using FSMs The paper illustrates the technique with a running example of a Web-based course student information system and introduces a prototype implementation to support the technique
TL;DR: A rapid computational approach identified three mutations within a model enzyme that produced a 10°C increase in apparent melting temperature Tm and a 30-fold increase in half-life at 50°C, with no reduction in catalytic efficiency.
Abstract: Thermostabilizing an enzyme while maintaining its activity for industrial or biomedical applications can be difficult with traditional selection methods. We describe a rapid computational approach that identified three mutations within a model enzyme that produced a 10 degrees C increase in apparent melting temperature T(m) and a 30-fold increase in half-life at 50 degrees C, with no reduction in catalytic efficiency. The effects of the mutations were synergistic, giving an increase in excess of the sum of their individual effects. The redesigned enzyme induced an increased, temperature-dependent bacterial growth rate under conditions that required its activity, thereby coupling molecular and metabolic engineering.
TL;DR: Edible coatings can be used to help in the preservation of minimally processed fruits, providing a partial barrier to moisture, oxygen and carbon dioxide, improving mechanical handling properties, carrying additives, avoiding volatiles loss, and even contributing to the production of aroma volatile.
Abstract: The production of fresh-cut fruits is increasingly becoming an important task as consumers are more aware of the importance of healthy eating habits, and have less time for food preparation. A fresh-cut fruit is a fruit that has been physically altered from its original state (trimmed, peeled, washed and/or cut), but remains in a fresh state. Unfortunately since fruits have living tissue, they undergo enzymatic browning, texture decay, microbial contamination, and undesirable volatile production, highly reducing their shelf life if they are in any way wounded. Edible coatings can be used to help in the preservation of minimally processed fruits, providing a partial barrier to moisture, oxygen and carbon dioxide, improving mechanical handling properties, carrying additives, avoiding volatiles loss, and even contributing to the production of aroma volatiles.
TL;DR: The abstinence-based incentive procedure, which provided a mean of 203 dollars in prizes per participant, was efficacious in improving retention and associated abstinence outcomes.
Abstract: Context Contingency management interventions that provide tangible incentives based on objective indicators of drug abstinence are efficacious in improving outcomes in substance abusers, but these treatments have rarely been implemented in community-based settings. Objective To evaluate the efficacy of an abstinence-based contingency management intervention as an addition to usual care in community treatment settings. Design Random assignment to usual care or usual care plus abstinence-based incentives for 12 weeks. Setting Eight community-based outpatient psychosocial drug abuse treatment programs. Participants A total of 415 cocaine or methamphetamine users beginning outpatient substance abuse treatment. Intervention All participants received standard care, and those assigned to the abstinence-based incentive condition also earned chances to win prizes for submitting substance-free urine samples; the chances of winning prizes increased with continuous time abstinent. Main Outcome Measures Retention, counseling attendance, total number of substance-free samples provided, percentage of stimulant- and alcohol-free samples submitted, and longest duration of confirmed stimulant abstinence. Results Participants assigned to the abstinence-based incentive condition remained in treatment for a mean ± SD of 8.0 ± 4.2 weeks and attended a mean ± SD of 19.2 ± 16.8 counseling sessions compared with 6.9 ± 4.4 weeks and 15.7 ± 14.4 sessions for those assigned to the usual care condition ( P P Conclusion The abstinence-based incentive procedure, which provided a mean of $203 in prizes per participant, was efficacious in improving retention and associated abstinence outcomes.
TL;DR: In this article, the authors used EM38 data collected in the vertical dipole orientation (0-150cm depth) and Veris 3100 data collected at 0-100cm depth to investigate the relationship between apparent electrical conductivity (EC"a) of the soil profile and measured soil properties.
09 May 2005
TL;DR: The thesis of this paper is that the changing environment requires a new look at the operation of the power grid and a complete redesign of the control, communication and computation infrastructure.
Abstract: The power grid is not only a network interconnecting generators and loads through a transmission and distribution system, but is overlaid with a communication and control system that enables economic and secure operation. This multilayered infrastructure has evolved over many decades utilizing new technologies as they have appeared. This evolution has been slow and incremental, as the operation of the power system consisting of vertically integrated utilities has, until recently, changed very little. The monitoring of the grid is still done by a hierarchical design with polling for data at scanning rates in seconds that reflects the conceptual design of the 1960s. This design was adequate for vertically integrated utilities with limited feedback and wide-area controls; however, the thesis of this paper is that the changing environment, in both policy and technology, requires a new look at the operation of the power grid and a complete redesign of the control, communication and computation infrastructure. We provide several example novel control and communication regimes for such a new infrastructure.
TL;DR: In this paper, the authors explored the effects of ambient scent and music on consumers' evaluations of a store, its environment and offered merchandise, and found that the effect of adding an ambient Christmas scent is moderated by the nature of the background music.