Institution
Washington State University
Education•Pullman, Washington, United States•
About: Washington State University is a education organization based out in Pullman, Washington, United States. It is known for research contribution in the topics: Population & Gene. The organization has 26947 authors who have published 57736 publications receiving 2341509 citations. The organization is also known as: WSU & Wazzu.
Topics: Population, Gene, Poison control, Catalysis, Hordeum vulgare
Papers published on a yearly basis
Papers
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TL;DR: Observations indicate ancestral exposure to DDT can promote obesity and associated disease transgenerationally, indicating the etiology of disease such as obesity may be in part due to environmentally induced epigenetic transgenerational inheritance.
Abstract: Ancestral environmental exposures to a variety of environmental factors and toxicants have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. The present work examined the potential transgenerational actions of the insecticide dichlorodiphenyltrichloroethane (DDT) on obesity and associated disease. Outbred gestating female rats were transiently exposed to a vehicle control or DDT and the F1 generation offspring bred to generate the F2 generation and F2 generation bred to generate the F3 generation. The F1 and F3 generation control and DDT lineage rats were aged and various pathologies investigated. The F3 generation male sperm were collected to investigate methylation between the control and DDT lineage male sperm. The F1 generation offspring (directly exposed as a fetus) derived from the F0 generation exposed gestating female rats were not found to develop obesity. The F1 generation DDT lineage animals did develop kidney disease, prostate disease, ovary disease and tumor development as adults. Interestingly, the F3 generation (great grand-offspring) had over 50% of males and females develop obesity. Several transgenerational diseases previously shown to be associated with metabolic syndrome and obesity were observed in the testis, ovary and kidney. The transgenerational transmission of disease was through both female (egg) and male (sperm) germlines. F3 generation sperm epimutations, differential DNA methylation regions (DMR), induced by DDT were identified. A number of the genes associated with the DMR have previously been shown to be associated with obesity. Observations indicate ancestral exposure to DDT can promote obesity and associated disease transgenerationally. The etiology of disease such as obesity may be in part due to environmentally induced epigenetic transgenerational inheritance.
342 citations
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TL;DR: In the Western Ghats between latitudes 18° 20′ N and 19° 15′ N, 7000 km2 of Deccan basalt has been mapped with the primary objective of establishing a flow stratigraphy as a guide to the volcanic history of the flood basalts.
Abstract: In the Western Ghats between latitudes 18° 20′ N and 19° 15′ N, 7000 km2 of Deccan Basalt have been mapped with the primary objective of establishing a flow stratigraphy as a guide to the volcanic history of the flood basalts. Using over 70 measured vertical sections, major and trace element analyses of nearly 1200 samples, and rare-earth and87Sr/86Sr determinations for over 60 samples, we divide the basalt into three subgroups and ten formations. In this paper we describe the seven principal formations in the area and the most prominent individual flows. The Kalsubai Subgroup is formed by the lower five formations, the Jawhar, Igatpuri, Neral, Thakurvadi, and Bhimashankar formations, from botton to top. In these formations amygdaloidal compound flows predominate and have a typically high MgO content, including picrite basalt (> 10% MgO) and picrite (> 18% MgO) with phenocrysts of olivine and clinopyroxene. These flows are separated by others which contain giant plagioclase phenocrysts and have more evolved chamical compositions. The Lonavala Subgroup overlies the Kalsubai and is composed of two formations, the Khandala and the Bushe. Both are readily recognized in the field and by their chemical compositions. The Wai Subgroup includes the upper three formations, the Poladpur, the Ambenali, and the Mahabaleshwar. The whole subgroup is composed of simple flows with well-developed flow tops, small phenocrysts of plagioclase, pyroxene and olivine, and relatively evolved bulk compositions. Distribution and variation in thickness of the straitigraphic units within the Western Ghats provide a first comprehensive view of the development of the Deccan volcanic edifice. The persistent southerly dip and gentle southerly plunging anticlinal form of the flows, the lensoid shape of many of the formations, and nearly randomly oriented feeder-dike system are together interpreted as evidence of a central volcanic edifice formed as the Indian plate drifted northward over a mantle plume or hot spot.
342 citations
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TL;DR: Structural equation modeling showed that those high in CFC-Future engage in exercise and healthy eating because they adopt a promotion orientation, and future use of the two-factor C FC-14 scale is encouraged to shed additional light on how concern with future and concern with immediate consequences (proper) differentially impact the way people resolve a host of intertemporal dilemmas.
Abstract: The authors extended research linking individual differences in consideration of future consequences (CFC) with health behaviors by (a) testing whether individual differences in regulatory focus would mediate that link and (b) highlighting the value of a revised, two-factor CFC-14 scale with subscales assessing concern with future consequences (CFC-Future) and concern with immediate consequences (CFC-Immediate) proper. Exploratory and confirmatory factor analyses of the revised CFC-14 scale supported the presence of two highly reliable factors (CFC-Future and CFC-Immediate; αs from .80 to .84). Moreover, structural equation modeling showed that those high in CFC-Future engage in exercise and healthy eating because they adopt a promotion orientation. Future use of the two-factor CFC-14 scale is encouraged to shed additional light on how concern with future and concern with immediate consequences (proper) differentially impact the way people resolve a host of intertemporal dilemmas (e.g., health, financial, and environmental behavior).
342 citations
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TL;DR: In this paper, the authors show that despite over a decade of rising employment within this segment of the economy, researchers are only beg for more research on interactive service jobs, despite their increasing importance.
Abstract: Interactive service jobs are an increasingly important feature of the occupational landscape. Despite over a decade of rising employment within this segment of the economy, researchers are only beg...
342 citations
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TL;DR: In this paper, the mechanisms and consequences of plastic strain localizations exhibited in tensile stress-strain behaviors, fracture and fatigue are discussed, including important practical considerations and historical background; then dislocation mechanics based details are developed in subsequent sections.
342 citations
Authors
Showing all 27183 results
Name | H-index | Papers | Citations |
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Anil K. Jain | 183 | 1016 | 192151 |
Martin Karplus | 163 | 831 | 138492 |
Herbert A. Simon | 157 | 745 | 194597 |
Suvadeep Bose | 154 | 960 | 129071 |
Rajesh Kumar | 149 | 4439 | 140830 |
Kevin Murphy | 146 | 728 | 120475 |
Jonathan D. G. Jones | 129 | 417 | 80908 |
Douglas E. Soltis | 127 | 612 | 67161 |
Peter W. Kalivas | 123 | 428 | 52445 |
Chris Somerville | 122 | 284 | 45742 |
Pamela S. Soltis | 120 | 543 | 61080 |
Yuehe Lin | 118 | 641 | 55399 |
Howard I. Maibach | 116 | 1821 | 60765 |
Jizhong Zhou | 115 | 766 | 48708 |
Farshid Guilak | 110 | 480 | 41327 |