scispace - formally typeset

Washington University in St. Louis

EducationSt Louis, Missouri, United States
About: Washington University in St. Louis is a(n) education organization based out in St Louis, Missouri, United States. It is known for research contribution in the topic(s): Population & Transplantation. The organization has 77941 authors who have published 163766 publication(s) receiving 10062651 citation(s). The organization is also known as: WUSTL & Washington University. more

Topics: Population, Transplantation, Cancer more

Showing all 77941 results

Walter C. Willett3342399413322
Eric S. Lander301826525976
Meir J. Stampfer2771414283776
Ronald C. Kessler2741332328983
Graham A. Colditz2611542256034
Shizuo Akira2611308320561
Eugene Braunwald2301711264576
John Q. Trojanowski2261467213948
Younan Xia216943175757
David J. Hunter2131836207050
Eric N. Olson206814144586
Rob Knight2011061253207
Robert M. Califf1961561167961
Frank E. Speizer193636135891
Nicholas G. Martin1921770161952

Open accessJournal Article
Abstract: Since 1922 when Wu proposed the use of the Folin phenol reagent for the measurement of proteins, a number of modified analytical procedures utilizing this reagent have been reported for the determination of proteins in serum, in antigen-antibody precipitates, and in insulin. Although the reagent would seem to be recommended by its great sensitivity and the simplicity of procedure possible with its use, it has not found great favor for general biochemical purposes. In the belief that this reagent, nevertheless, has considerable merit for certain application, but that its peculiarities and limitations need to be understood for its fullest exploitation, it has been studied with regard to effects of variations in pH, time of reaction, and concentration of reactants, permissible levels of reagents commonly used in handling proteins, and interfering substances. Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein. more

Topics: Reagent (61%), Sulfhydryl reagent (61%), Folin–Ciocalteu reagent (61%) more

285,427 Citations

Open accessBook
Douglass C. North1Institutions (1)
01 Jan 1990-
Abstract: Continuing his groundbreaking analysis of economic structures, Douglass North develops an analytical framework for explaining the ways in which institutions and institutional change affect the performance of economies, both at a given time and over time. Institutions exist, he argues, due to the uncertainties involved in human interaction; they are the constraints devised to structure that interaction. Yet, institutions vary widely in their consequences for economic performance; some economies develop institutions that produce growth and development, while others develop institutions that produce stagnation. North first explores the nature of institutions and explains the role of transaction and production costs in their development. The second part of the book deals with institutional change. Institutions create the incentive structure in an economy, and organisations will be created to take advantage of the opportunities provided within a given institutional framework. North argues that the kinds of skills and knowledge fostered by the structure of an economy will shape the direction of change and gradually alter the institutional framework. He then explains how institutional development may lead to a path-dependent pattern of development. In the final part of the book, North explains the implications of this analysis for economic theory and economic history. He indicates how institutional analysis must be incorporated into neo-classical theory and explores the potential for the construction of a dynamic theory of long-term economic change. Douglass C. North is Director of the Center of Political Economy and Professor of Economics and History at Washington University in St. Louis. He is a past president of the Economic History Association and Western Economics Association and a Fellow, American Academy of Arts and Sciences. He has written over sixty articles for a variety of journals and is the author of The Rise of the Western World: A New Economic History (CUP, 1973, with R.P. Thomas) and Structure and Change in Economic History (Norton, 1981). Professor North is included in Great Economists Since Keynes edited by M. Blaug (CUP, 1988 paperback ed.) more

Topics: Institutional analysis (63%), Cliometrics (55%), Comparative politics (51%) more

26,472 Citations

Open accessJournal ArticleDOI: 10.1038/NMETH.F.303
11 Apr 2010-Nature Methods
Abstract: Supplementary Figure 1 Overview of the analysis pipeline. Supplementary Table 1 Details of conventionally raised and conventionalized mouse samples. Supplementary Discussion Expanded discussion of QIIME analyses presented in the main text; Sequencing of 16S rRNA gene amplicons; QIIME analysis notes; Expanded Figure 1 legend; Links to raw data and processed output from the runs with and without denoising. more

24,116 Citations

Open accessJournal ArticleDOI: 10.1038/35057062
Eric S. Lander1, Lauren Linton1, Bruce W. Birren1, Chad Nusbaum1  +245 moreInstitutions (29)
15 Feb 2001-Nature
Abstract: The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence. more

Topics: Cancer genome sequencing (61%), Hybrid genome assembly (59%), Cancer Genome Project (58%) more

21,023 Citations

Journal ArticleDOI: 10.1021/BI00591A005
27 Nov 1979-Biochemistry
Abstract: Intact ribonucleic acid (RNA) has been prepared from tissues rich in ribonuclease such as the rat pancreas by efficient homogenization in a 4 M solution of the potent protein denaturant guanidinium thiocyanate plus 0.1 M 2-mercaptoethanol to break protein disulfide bonds. The RNA was isolated free of protein by ethanol precipitation or by sedimentation through cesium chloride. Rat pancreas RNA obtained by these means has been used as a source for the purification of alpha-amylase messenger ribonucleic acid. more

19,784 Citations

No. of papers from the Institution in previous years

Top Attributes

Show by:

Institution's top 5 most impactful journals

Journal of Biological Chemistry

2.9K papers, 573.2K citations

Social Science Research Network

2.2K papers, 62.2K citations


1.5K papers, 69.5K citations


1.5K papers, 6.8K citations

Network Information
Related Institutions
Duke University

200.3K papers, 10.7M citations

97% related

University of Pittsburgh

201K papers, 9.6M citations

96% related

Yale University

220.6K papers, 12.8M citations

96% related

Case Western Reserve University

106.5K papers, 5M citations

96% related

University of Pennsylvania

257.6K papers, 14.1M citations

96% related