Institution
Westerly Hospital
Healthcare•Westerly, Rhode Island, United States•
About: Westerly Hospital is a healthcare organization based out in Westerly, Rhode Island, United States. It is known for research contribution in the topics: Aerobic exercise & ABL. The organization has 11 authors who have published 14 publications receiving 2235 citations.
Topics: Aerobic exercise, ABL, Imatinib, Ureteroscopy, Population
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TL;DR: The acquisition of a T674I resistance mutation at the time of relapse demonstrates that FIP1L1-PDGFRalpha is the target of imatinib, and data indicate that the deletion of genetic material may result in gain-of-function fusion proteins.
Abstract: Background Idiopathic hypereosinophilic syndrome involves a prolonged state of eosinophilia associated with organ dysfunction. It is of unknown cause. Recent reports of responses to imatinib in patients with the syndrome suggested that an activated kinase such as ABL, platelet-derived growth factor receptor (PDGFR), or KIT, all of which are inhibited by imatinib, might be the cause. Methods We treated 11 patients with the hypereosinophilic syndrome with imatinib and identified the molecular basis for the response. Results Nine of the 11 patients treated with imatinib had responses lasting more than three months in which the eosinophil count returned to normal. One such patient had a complex chromosomal abnormality, leading to the identification of a fusion of the Fip1-like 1 (FIP1L1) gene to the PDGFRα (PDGFRA) gene generated by an interstitial deletion on chromosome 4q12. FIP1L1-PDGFRα is a constitutively activated tyrosine kinase that transforms hematopoietic cells and is inhibited by imatinib (50 perce...
1,660 citations
TL;DR: KPC412 is effective for treatment of FIP1L1-PDGFRalpha-induced disease and of imatinib-induced resistance due to the T674I mutation and the potential of alternative kinase inhibitors to overcome resistance in target tyrosine kinases is demonstrated.
233 citations
TL;DR: While preliminary, this study is one of the first to demonstrate the feasibility of incorporating aerobic exercise during drug abuse treatment, and those who attended at least 75% of the exercise sessions had significantly better substance use outcomes than those who did not.
132 citations
TL;DR: The authors discuss the rationale and review potential mechanisms of action whereby exercise might benefit alcohol dependent patients in recovery, and describe the development of a 12-week moderate-intensity aerobic exercise program as an adjunctive intervention for alcohol dependent Patients in recovery.
Abstract: Alcohol use disorders are a major public health concern. Despite the demonstrated efficacy of a number of different treatments for alcohol dependence, relapse remains a major problem. Healthy lifestyle changes may contribute to long-term maintenance of recovery, and interventions targeting physical activity, in particular, may be especially valuable as an adjunct to alcohol treatment. In this article, the authors discuss the rationale and review potential mechanisms of action whereby exercise might benefit alcohol dependent patients in recovery. They then describe the development of a 12-week moderate-intensity aerobic exercise program as an adjunctive intervention for alcohol dependent patients in recovery. Preliminary data from a pilot study (N = 19) are presented, and the overall significance of this research effort is discussed.
125 citations
TL;DR: Limited ureteroscopy can be carried out in adults, using a regular pediatric cystoscope, using this equipment now available in many hospitals.
84 citations
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