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Institution

William Jennings Bryan Dorn VA Medical Center

HealthcareColumbia, South Carolina, United States
About: William Jennings Bryan Dorn VA Medical Center is a healthcare organization based out in Columbia, South Carolina, United States. It is known for research contribution in the topics: Population & Warfarin. The organization has 41 authors who have published 41 publications receiving 2091 citations. The organization is also known as: Dorn VAMC.

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Journal ArticleDOI
TL;DR: Results suggest that women participating in social and economic activities enhances their autonomy, and other factors affecting women's autonomy are female literacy, educational attainment and households' economic status.

37 citations

Journal ArticleDOI
TL;DR: In this article, the efficacy and safety of treatment for nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM) were reviewed.
Abstract: Objective:To review current literature for the efficacy and safety of treatment for nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM).Data sources:A PubMed l...

28 citations

Journal ArticleDOI
TL;DR: In this paper, the authors reviewed data involving rituximab and ofatumumab, doxorubicin, corticosteroids, tumor necrosis factor antagonists, tyrosine kinases, bortezomib, hematologic stem cell transplantation, and DAAs for HCV treatment.
Abstract: Hepatitis B virus (HBV) is a global disease with significant morbidity and mortality. Worldwide, ~257 million people are chronically infected with HBV, defined as having a positive hepatitis B surface antigen, but millions more have prior HBV exposure indicated by positive hepatitis B core antibody. Reactivation of hepatitis B implies a sudden increase in viral replication in a patient with chronic HBV infection or prior HBV exposure. Hepatitis B virus reactivation (HBVr) can occur spontaneously, but it is more commonly triggered by immunosuppressive therapies for cancer, immunologic diseases, or transplantation. Elimination of hepatitis C virus (HCV) in HBV-HCV coinfected individuals treated with direct-acting antivirals (DAAs) has also been identified as an important cause of HBVr. Hepatitis B virus reactivation is an underappreciated but important complication of common medical therapies that can delay treatment or result in clinical episodes of hepatitis, hepatic failure, or death. In this review, factors associated with HBVr, particularly medication-related risks, are explored. We review data involving rituximab and ofatumumab, doxorubicin, corticosteroids, tumor necrosis factor antagonists, tyrosine kinases, bortezomib, hematologic stem cell transplantation, and DAAs for HCV treatment. In addition, we discuss screening strategies, choice of antiviral prophylaxis, and the optimal duration of therapy for HBVr. With additional awareness, screening, and appropriate antiviral therapy, it is expected that most cases of HBVr can be prevented.

28 citations

Journal ArticleDOI
TL;DR: The present review describes research in the laboratory that has focused on conditioned bradycardia as a model system of a rapidly acquired associative system and contrast it with the more slowly acquired Pavlovian conditioned eyeblink response.
Abstract: It has become clear from the study of different response systems during classical conditioning that some responses are acquired quite rapidly and others show a much slower rate of acquisition. The most often studied rapidly acquired responses have been classically conditioned autonomic changes (e.g., heart rate); the slowly acquired responses most often studied are skeletal responses, such as the eyeblink or leg flexion response. Although there are various other differences between rapidly acquired and slowly acquired responses, we have suggested that the most important difference is the possibility that they represent different stages of the learning process. In the present review I describe research in our laboratory that has focused on conditioned bradycardia as a model system of a rapidly acquired associative system and contrast it with the more slowly acquired Pavlovian conditioned eyeblink response. I also describe the generality of conditioned bradycardia and discuss the differential role of subdivisions of the prefrontal cortex as a substrate for mediating this response. Finally, I briefly discuss the other brain areas involved in conditioned bradycardia, and its functional significance as it relates to the learning process.

27 citations

Journal ArticleDOI
09 May 2012-JAMA
TL;DR: It is shown that among elderly patients (75 years) who initiated dialysis, the proportion who had early initiation increased from 25% in 1996 to 64% in 2009, and similar to patients with diabetes who underwent dialysis in the 1970s, early initiation of dialysisinelderly patients may have little likelihood of long-term survival or improvement in quality of life.
Abstract: ORTY YEARS AGO, AN ARTICLE INJAMA ENTITLED“THE SadTruthAboutHemodialysisinDiabeticNephropathy”highlightedthepooroutcomesforpatientswith diabeteswhoweretreatedwithdialysis. 1 Intheearly 1970s some patients with diabetes were not offered dialysis because of expected poor outcomes. The problems of visual deterioration and chronic fluid overload have been largely resolved with laser therapy for diabetic retinopathy and vastly improved dialysis techniques. In a report published in 1972, among 9 patients with renal failure resulting from diabetic nephropathy who were treated by hemodialysis, survival was 22% (2 patients) at the end of 1 year, 1 whereas in 2008, data from the US Renal Data System indicate that for patients with diabetes who initiated dialysis, survival was 81% at the end of 1 year. 2 RecenttrendsintheincidentUSdialysispopulationhave shown a marked increase in the number of patients older than 75 years (elderly) who initiate dialysis early, at estimated glomerular filtration rates (eGFR) of 10 mL/min per 1.73 m 2 or higher. Among elderly patients (75 years) who initiated dialysis, the proportion who had early initiation increased from 25% in 1996 to 64% in 2009. 2 Similar to patients with diabetes who underwent dialysis in the 1970s, earlyinitiationofdialysisinelderlypatientsmayhave“little likelihood of long-term survival or improvement in quality of life.” 1

26 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20231
20215
20205
20195
20189
20177