Institution
Wills Eye Institute
Healthcare•Philadelphia, Pennsylvania, United States•
About: Wills Eye Institute is a healthcare organization based out in Philadelphia, Pennsylvania, United States. It is known for research contribution in the topics: Glaucoma & Visual acuity. The organization has 1641 authors who have published 2828 publications receiving 99913 citations.
Papers published on a yearly basis
Papers
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TL;DR: The most effective therapy prescribed by the most careful clinician will control hypertension only if patients are motivated, and empathy builds trust and is a potent motivator.
Abstract: The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure" provides a new guideline for hypertension prevention and management. The following are the key messages(1) In persons older than 50 years, systolic blood pressure (BP) of more than 140 mm Hg is a much more important cardiovascular disease (CVD) risk factor than diastolic BP; (2) The risk of CVD, beginning at 115/75 mm Hg, doubles with each increment of 20/10 mm Hg; individuals who are normotensive at 55 years of age have a 90% lifetime risk for developing hypertension; (3) Individuals with a systolic BP of 120 to 139 mm Hg or a diastolic BP of 80 to 89 mm Hg should be considered as prehypertensive and require health-promoting lifestyle modifications to prevent CVD; (4) Thiazide-type diuretics should be used in drug treatment for most patients with uncomplicated hypertension, either alone or combined with drugs from other classes. Certain high-risk conditions are compelling indications for the initial use of other antihypertensive drug classes (angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers, beta-blockers, calcium channel blockers); (5) Most patients with hypertension will require 2 or more antihypertensive medications to achieve goal BP (<140/90 mm Hg, or <130/80 mm Hg for patients with diabetes or chronic kidney disease); (6) If BP is more than 20/10 mm Hg above goal BP, consideration should be given to initiating therapy with 2 agents, 1 of which usually should be a thiazide-type diuretic; and (7) The most effective therapy prescribed by the most careful clinician will control hypertension only if patients are motivated. Motivation improves when patients have positive experiences with and trust in the clinician. Empathy builds trust and is a potent motivator. Finally, in presenting these guidelines, the committee recognizes that the responsible physician's judgment remains paramount.
4,565 citations
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TL;DR: It is demonstrated that aflibercept is an effective treatment for AMD, with the every-2-month regimen offering the potential to reduce the risk from monthly intravitreal injections and the burden of monthly monitoring.
1,894 citations
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TL;DR: Intravitreal triamcinolone is a promising therapeutic method for diabetic macular edema that fails to respond to conventional laser photocoagulation and complications do not appear to be prohibitive.
1,005 citations
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TL;DR: In this paper, the safety and efficacy of dexamethasone intravitreal implant (DEX implant; OZURDEX, Allergan, Inc., Irvine, CA) compared with sham in eyes with vision loss due to macular edema (ME) associated with BRVO or central retinal vein occlusion (CRVO).
955 citations
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TL;DR: It is shown that Norrin and Fz4 function as a ligand-receptor pair that plays a central role in vascular development in the eye and ear, and it is indicated that ligands unrelated to Wnts can act through Fz receptors.
818 citations
Authors
Showing all 1687 results
Name | H-index | Papers | Citations |
---|---|---|---|
Abass Alavi | 113 | 1298 | 56672 |
David Spiegel | 106 | 733 | 46276 |
Jerry A. Shields | 105 | 1267 | 48629 |
Carol L. Shields | 102 | 1424 | 46800 |
Roy W. Beck | 91 | 376 | 25493 |
Anna T. Meadows | 86 | 259 | 25270 |
David S. Zee | 75 | 424 | 25454 |
David W. Andrews | 75 | 373 | 32400 |
Glenn J. Jaffe | 73 | 367 | 22256 |
Thomas A. Gennarelli | 72 | 235 | 23048 |
David Friedman | 69 | 257 | 17202 |
Robert H. Rosenwasser | 67 | 447 | 22234 |
Harminder S Dua | 66 | 420 | 17371 |
Peter J. Savino | 66 | 269 | 13640 |
Gholam A. Peyman | 64 | 716 | 19091 |