Wishaw General Hospital

About: Wishaw General Hospital is a healthcare organization based out in Wishaw, Scotland, United Kingdom. It is known for research contribution in the topics: Population & Survival rate. The organization has 256 authors who have published 222 publications receiving 4324 citations.

Exaggerated adrenarche in a cohort of Scottish children: clinical features and biochemistry

Abstract: Summary Objective To investigate the reported association between exaggerated adrenarche (EA) and reduced foetal growth and to identify possible risk factors for future morbidity in Scottish children with clinical features of EA. Design Three-year prospective study. Measurements Auxology, blood pressure (BP), biochemical analysis of blood and urine, pelvic ultrasound in girls. Results Fifty-two patients were recruited of whom one girl had nonclassical congenital adrenal hyperplasia (17-OHP 17 nmol/l) and one had insufficient blood for analysis. The final cohort comprised 42 girls of mean (SD) age 7·7 (0·99) and eight boys of 8·8 (0·67) years. Mean (SD) birth weight was 3·27 (0·49) and 3·10 (0·76) kg in girls and boys respectively. Height/weight SDS were 1·13/1·69 in girls and 1·69/1·88 in boys. Mean systolic/diastolic BP was 107·8/60·4 (50th–75th centile) in girls and 115·5/63·9 (75th–91st centile) in boys. Uterine and ovarian development was prepubertal. Median serum dehydroepiandrosterone sulphate (DHEAS) was 2·1 and 4·1 μmol/l, androstenedione 3·1 and 3·8 nmol/l in girls and boys respectively, with DHEAS within the reference range/undetectable in 18/2 and androstenedione in 12/6 patients. Fasting insulin was 9·0 and 15·0 mU/l in girls and boys respectively, with concomitant low normal SHBG. Anti-Mullerian hormone (AMH) was 15·7 pmol/l in 27 girls, compared with 5·0 pmol/l in normal girls aged 5–8 years. Conclusions Our Scottish EA cohort showed female predominance, no evidence of reduced foetal growth, a tendency to overweight with commensurate mild hyperinsulinaemia and modest elevation of serum androgens in some patients. We have found raised AMH levels in the girls, indicating advanced ovarian follicular development.

Recent advances of hemorrhage management in severe trauma.

Abstract: Trauma is one of the most common causes of mortality worldwide with a substantial percentage of deaths resulting secondary to haemorrhages, which are preventable and treatable when adequately managed This paper offers a review of the current literature on how to successfully resuscitate patients with major haemorrhage

Imaging periprosthetic osteolysis around total knee arthroplasties using a human cadaver model

Abstract: We examined the sensitivity and accuracy of measuring osteolysis around total knee arthroplasty (TKA) on radiographs, computed tomography (CT), and magnetic resonance imaging (MRI) in a cadaver model Fifty-four simulated osteolytic defects ranging from 07 to 14 cm(3) were created in 6 cadaver knees implanted with either a cemented or an uncemented TKA Three blinded investigators assessed the presence, location, and volume of defects on radiographs and CT and MRI scans with metal reduction protocols Both CT and MRI had significantly higher sensitivities and specificities than did plain radiographs (P < 005) Overall, there was no difference in the accuracy of defect volume measurements between CT and MRI (P = 574) This study demonstrates the limitations of radiographs and the high sensitivity and specificity of both CT and MRI in assessing osteolysis around TKA

Occupational eye injuries: a continuing problem.

Abstract: BACKGROUND: Ocular trauma is a worldwide cause of visual morbidity, a significant proportion of which occurs in the workplace. This is largely preventable with the use of protective eyewear and strict compliance. AIM: To analyse the type of occupational eye injuries that occur and to document the use of eye protection in patients presenting to a UK district general hospital. METHODS: A pilot retrospective case note analysis of all ocular injuries seen in one calendar month was performed. A prospective survey of consecutive occupational ocular injuries presenting to this district general accident and emergency (A&E) department over a 2-month period was then carried out. Demographics, aetiology, eye protection usage and clinical details were recorded and analysed. RESULTS: Of all eye patients attending this A&E, 31% (87/283) were due to occupational eye injuries. Of 55 prospectively reviewed patients with occupational eye injuries, the majority had minor injuries. Of the cases where eye protection was recorded, 56% (18/32) were not wearing any protection and 44% (14/32) wore eye protection at the time of injury. CONCLUSIONS: Occupational eye injuries are a commonly seen ocular complaint in the A&E department. Provision of appropriate eyewear protection and worker education is required to minimize the incidence of ocular injury in the workplace. Language: en

Anal incontinence and quality of life following obstetric anal sphincter injury.

Abstract: Purpose The objective of our study was to identify the number of women who have long-term ano-rectal symptoms following primary repair of obstetric anal sphincter injury (OASI) and the effect on their quality of life. We also wished to determine the impact of the injury on decision for future pregnancies and mode of delivery in subsequent pregnancies.