Institution
Wolfson Centre for Age-Related Diseases
About: Wolfson Centre for Age-Related Diseases is a based out in . It is known for research contribution in the topics: Dementia & Dementia with Lewy bodies. The organization has 558 authors who have published 1203 publications receiving 77917 citations.
Papers published on a yearly basis
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TL;DR: Specific interactions between the brain endothelium, astrocytes and neurons that may regulate blood–brain barrier function are explored to lead to the development of new protective and restorative therapies.
Abstract: The blood-brain barrier, which is formed by the endothelial cells that line cerebral microvessels, has an important role in maintaining a precisely regulated microenvironment for reliable neuronal signalling. At present, there is great interest in the association of brain microvessels, astrocytes and neurons to form functional 'neurovascular units', and recent studies have highlighted the importance of brain endothelial cells in this modular organization. Here, we explore specific interactions between the brain endothelium, astrocytes and neurons that may regulate blood-brain barrier function. An understanding of how these interactions are disturbed in pathological conditions could lead to the development of new protective and restorative therapies.
4,578 citations
TL;DR: A clear understanding of the mechanisms of action of flavonoids, either as antioxidants or modulators of cell signalling, and the influence of their metabolism on these properties are key to the evaluation of these potent biomolecules as anticancer agents, cardioprotectants, and inhibitors of neurodegeneration.
1,828 citations
Karolinska Institutet1, Karolinska University Hospital2, Pasteur Institute3, University of Toulouse4, Wolfson Centre for Age-Related Diseases5, University of Cambridge6, University of New South Wales7, Pierre-and-Marie-Curie University8, Umeå University9, La Trobe University10, University of British Columbia11, University of Geneva12, Douglas Mental Health University Institute13, Alzheimer Europe14, German Center for Neurodegenerative Diseases15, University of Cologne16, London School of Economics and Political Science17, Radboud University Nijmegen18, Rockefeller University19, VU University Medical Center20, University of Southern California21, Brigham and Women's Hospital22, University of Copenhagen23, UCL Institute of Neurology24, University of Gothenburg25
TL;DR: This poster aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the physical and cognitive properties of Alzheimer's disease and other dementias.
Abstract: Defeating Alzheimer's disease and other dementias : a priority for European science and society
1,215 citations
TL;DR: Here microglia and astrocytes respond to the increased input from the periphery and change morphology, increase in number and release pro-nociceptive mediators such as ATP, cytokines and chemokines which contribute to central sensitization which is fundamental for the generation of allodynia, hyperalgesia and spontaneous pain.
Abstract: Chronic pain, both inflammatory and neuropathic, is a debilitating condition in which the pain experience persists after the painful stimulus has resolved. The efficacy of current treatment strategies using opioids, NSAIDS and anticonvulsants is limited by the extensive side effects observed in patients, underlining the necessity for novel therapeutic targets. Preclinical models of chronic pain have recently provided evidence for a critical role played by glial cells in the mechanisms underlying the chronicity of pain, both at the site of damage in the periphery and in the dorsal horn of the spinal cord. Here microglia and astrocytes respond to the increased input from the periphery and change morphology, increase in number and release pro-nociceptive mediators such as ATP, cytokines and chemokines. These gliotransmitters can sensitise neurons by activation of their cognate receptors thereby contributing to central sensitization which is fundamental for the generation of allodynia, hyperalgesia and spontaneous pain.
1,079 citations
TL;DR: It is predicted that combinations of strategies will lead to improvements in outcome after SCI, and that individual therapies are unlikely to provide a panacea.
Abstract: Spinal cord injury (SCI) can lead to paraplegia or quadriplegia. Although there are no fully restorative treatments for SCI, various rehabilitative, cellular and molecular therapies have been tested in animal models. Many of these have reached, or are approaching, clinical trials. Here, we review these potential therapies, with an emphasis on the need for reproducible evidence of safety and efficacy. Individual therapies are unlikely to provide a panacea. Rather, we predict that combinations of strategies will lead to improvements in outcome after SCI. Basic scientific research should provide a rational basis for tailoring specific combinations of clinical therapies to different types of SCI.
980 citations
Authors
Showing all 558 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Barry Halliwell | 173 | 662 | 159518 |
| Peter J. Goadsby | 123 | 946 | 73783 |
| John T. O'Brien | 121 | 819 | 63242 |
| John N. Wood | 121 | 833 | 59874 |
| Clive Ballard | 117 | 736 | 61663 |
| Dag Aarsland | 109 | 616 | 52740 |
| Peter Jenner | 109 | 698 | 54102 |
| Ajay M. Shah | 107 | 585 | 35974 |
| Stephen B. McMahon | 103 | 355 | 37450 |
| John C. Marshall | 103 | 471 | 83314 |
| Edmund M. Clarke | 100 | 394 | 63043 |
| Elaine K. Perry | 97 | 342 | 40017 |
| Agneta Nordberg | 93 | 513 | 39763 |
| Anthony H. Dickenson | 86 | 353 | 24982 |
| Catherine Rice-Evans | 86 | 187 | 45590 |