Worcester Polytechnic Institute

About: Worcester Polytechnic Institute is a education organization based out in Worcester, Massachusetts, United States. It is known for research contribution in the topics: Population & Data envelopment analysis. The organization has 6270 authors who have published 12704 publications receiving 332081 citations. The organization is also known as: WPI.

Estimating the reproducibility of psychological science

Abstract: Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.

Digital Signal Processing: Principles, Algorithms, and Applications

Abstract: 1. Introduction. 2. Discrete-Time Signals and Systems. 3. The Z-Transform and Its Application to the Analysis of LTI Systems. 4. Frequency Analysis of Signals and Systems. 5. The Discrete Fourier Transform: Its Properties and Applications. 6. Efficient Computation of the DFT: Fast Fourier Transform Algorithms. 7. Implementation of Discrete-Time Systems. 8. Design of Digital Filters. 9. Sampling and Reconstruction of Signals. 10. Multirate Digital Signal Processing. 11. Linear Prediction and Optimum Linear Filters. 12. Power Spectrum Estimation. Appendix A. Random Signals, Correlation Functions, and Power Spectra. Appendix B. Random Numbers Generators. Appendix C. Tables of Transition Coefficients for the Design of Linear-Phase FIR Filters. Appendix D. List of MATLAB Functions. References and Bibliography. Index.

Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.

Abstract: Alzheimer's disease (AD) is the most common cause of progressive intellectual failure in aged humans. AD brains contain numerous amyloid plaques surrounded by dystrophic neurites, and show profound synaptic loss, neurofibrillary tangle formation and gliosis. The amyloid plaques are composed of amyloid beta-peptide (A beta), a 40-42-amino-acid fragment of the beta-amyloid precursor protein (APP). A primary pathogenic role for APP/A beta is suggested by missense mutations in APP that are tightly linked to autosomal dominant forms of AD. A major obstacle to elucidating and treating AD has been the lack of an animal model. Animals transgenic for APP have previously failed to show extensive AD-type neuropathology, but we now report the production of transgenic mice that express high levels of human mutant APP (with valine at residue 717 substituted by phenylalanine) and which progressively develop many of the pathological hallmarks of AD, including numerous extracellular thioflavin S-positive A beta deposits, neuritic plaques, synaptic loss, astrocytosis and microgliosis. These mice support a primary role for APP/A beta in the genesis of AD and could provide a preclinical model for testing therapeutic drugs.

Global Positioning System: Signals, Measurements, and Performance

Abstract: The Global Positioning System (GPS) is a satellite-based navigation and time transfer system developed by the U.S. Department of Defense. It serves marine, airborne, and terrestrial users, both military and civilian. Specifically, GPS includes the Standard Positioning Service (SPS) which provides civilian users with 100 meter accuracy, and it serves military users with the Precise Positioning Service (PPS) which provides 20-m accuracy. Both of these services are available worldwide with no requirement for a local reference station. In contrast, differential operation of GPS provides 2- to 10-m accuracy to users within 1000 km of a fixed GPS reference receiver. Finally, carrier phase comparisons can be used to provide centimeter accuracy to users within 10 km and potentially within 100 km of a reference receiver. This advanced tutorial will describe the GPS signals, the various measurements made by the GPS receivers, and estimate the achievable accuracies. It will not dwell on those aspects of GPS which are well known to those skilled in the radio communications art, such as spread-spectrum or code division multiple access. Rather, it will focus on topics which are more unique to radio navigation or GPS. These include code-carrier divergence, codeless tracking, carrier aiding, and narrow correlator spacing.

The dynamics of product innovation and firm competences

Abstract: This study examines how product innovation contributes to the renewal of the firm through its dynamic and reciprocal relation with the firm's competences Field research in five high-tech firms of varying age, size, and level of diversification is combined with analysis of existing theory to develop the findings of the study Based on the notion that new products are created by linking competences relating to technologies and customers, a typology is derived that classifies new product projects based on whether a new product can draw on existing competences, or whether it requires competences the firm does not yet have Following organizational learning theory, these options are conceptualized as exploitation and exploration These organizational learning concepts are used to gain a dynamic and path-dependent view of product innovation and firm development, and to reveal the unique nature and challenges of different types of product innovation Copyright © 2002 John Wiley & Sons, Ltd