Institution
Worcester Polytechnic Institute
Education•Worcester, Massachusetts, United States•
About: Worcester Polytechnic Institute is a education organization based out in Worcester, Massachusetts, United States. It is known for research contribution in the topics: Computer science & Population. The organization has 6270 authors who have published 12704 publications receiving 332081 citations. The organization is also known as: WPI.
Topics: Computer science, Population, Data envelopment analysis, Nonlinear system, Finite element method
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors focus on the rapid flows of identical, smooth, nearly elastic spheres and introduce a statistical description of the spheres' velocities based upon a velocity distribution function that contains improvements to the Maxwellian.
Abstract: We focus attention on the rapid flows of identical, smooth, nearly elastic spheres and introduce a statistical description of the spheres' velocities. Based upon a velocity distribution function that contains improvements to the Maxwellian, we calculate the rate at which momentum and energy are transferred across bumpy boundaries and obtain conditions that ensure the balance of momentum and energy at such boundaries. Using these conditions we carry out an approximate analysis of a granular shear flow driven by bumpy boundaries to obtain an explicit dependence of the slip velocity and resulting stresses on boundary roughness. Finally, we compare these results to those obtained by employing a theory based on a simple Maxwellian velocity distribution.
111 citations
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TL;DR: This work proposes an informative prior distribution for variable selection and proposes novel methods for computing the marginal distribution of the data for the logistic regression model.
Abstract: Summary. Bayesian selection of variables is often difficult to carry out because of the challenge in specifying prior distributions for the regression parameters for all possible models, specifying a prior distribution on the model space and computations. We address these three issues for the logistic regression model. For the first, we propose an informative prior distribution for variable selection. Several theoretical and computational properties of the prior are derived and illustrated with several examples. For the second, we propose a method for specifying an informative prior on the model space, and for the third we propose novel methods for computing the marginal distribution of the data. The new computational algorithms only require Gibbs samples from the full model to facilitate the computation of the prior and posterior model probabilities for all possible models. Several properties of the algorithms are also derived. The prior specification for the first challenge focuses on the observables in that the elicitation is based on a prior prediction yo for the response vector and a quantity ao quantifying the uncertainty in yo. Then, yo and ao are used to specify a prior for the regression coefficients semi-automatically. Examples using real data are given to demonstrate the methodology.
111 citations
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TL;DR: As *CDM is produced by human cells in a chemically defined culture medium and is mechanically robust, it may be a viable living tissue equivalent for many connective tissue replacement applications requiring initial mechanical stability yet a high degree of biocompatibility.
111 citations
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TL;DR: Characterization of Archaeoglobus fulgidus CopA, a model protein within the subfamily of P1B-1 type ATPases, has provided structural and mechanistic details on this group of transporters, showing their incapability to significantly contribute to the metal efflux required for survival in high copper environments.
Abstract: Cu+-ATPases play a key role in bacterial Cu+ homeostasis by participating in Cu+ detoxification and cuproprotein assembly. Characterization of Archaeoglobus fulgidus CopA, a model protein within the subfamily of P1B-1 type ATPases, has provided structural and mechanistic details on this group of transporters. Atomic resolution structures of cytoplasmic regulatory metal binding domains (MBDs) and catalytic actuator, phosphorylation, and nucleotide binding domains are available. These, in combination with whole protein structures resulting from cryo-electron microscopy analyses, have enabled the initial modeling of these transporters. Invariant residues in helixes 6, 7 and 8 form two transmembrane metal binding sites (TM-MBSs). These bind Cu+ with high affinity in a trigonal planar geometry. The cytoplasmic Cu+ chaperone CopZ transfers the metal directly to the TM-MBSs; however, loading both of the TM-MBSs requires binding of nucleotides to the enzyme. In agreement with the classical transport mechanism of P-type ATPases, occupancy of both transmembrane sites by cytoplasmic Cu+ is a requirement for enzyme phosphorylation and subsequent transport into the periplasmic or extracellular milieus. Recent transport studies have shown that all Cu+-ATPases drive cytoplasmic Cu+ efflux, albeit with quite different transport rates in tune with their various physiological roles. Archetypical Cu+-efflux pumps responsible for Cu+ tolerance, like the Escherichia coli CopA, have turnover rates ten times higher than those involved in cuproprotein assembly (or alternative functions). This explains the incapability of the latter group to significantly contribute to the metal efflux required for survival in high copper environments.
111 citations
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TL;DR: In this paper, the authors identify 11 key characteristic parameters of the gas diffusion layer (GDL) and their significance to its performance and examine the effect of adding multiple MPLs, MPL loading, and MPL particle size on cell performance under both wet and dry operating conditions.
110 citations
Authors
Showing all 6336 results
Name | H-index | Papers | Citations |
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Andrew G. Clark | 140 | 823 | 123333 |
Ming Li | 103 | 1669 | 62672 |
Joseph Sarkis | 101 | 482 | 45116 |
Arthur C. Graesser | 95 | 614 | 38549 |
Kevin J. Harrington | 85 | 682 | 33625 |
Kui Ren | 83 | 501 | 32490 |
Bart Preneel | 82 | 844 | 25572 |
Ming-Hui Chen | 82 | 525 | 29184 |
Yuguang Fang | 79 | 572 | 20715 |
Wenjing Lou | 77 | 311 | 29405 |
Bernard Lown | 73 | 330 | 20320 |
Joe Zhu | 72 | 231 | 19017 |
Y.S. Lin | 71 | 304 | 16100 |
Kevin Talbot | 71 | 268 | 15669 |
Christof Paar | 69 | 399 | 21790 |