Institution
Wrocław University of Technology
Education•Wrocław, Poland•
About: Wrocław University of Technology is a education organization based out in Wrocław, Poland. It is known for research contribution in the topics: Laser & Fuzzy logic. The organization has 13115 authors who have published 31279 publications receiving 338694 citations.
Topics: Laser, Fuzzy logic, Quantum dot, Optical fiber, Photoluminescence
Papers published on a yearly basis
Papers
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TL;DR: Quantitative EPR method was applied to characterise four types of humic acids derived from composts, soil, peat and soft brown coal, and it was recognised that the radical centres, which are enhanced by 'ammonia effect' are quenched in the formed HA-Cu(II) complexes.
89 citations
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TL;DR: In this article, the role of water in the mechanism of solute transport between aqueous phases, separated by a supported liquid membrane with ionic liquids, was evaluated using case-study solutes.
89 citations
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TL;DR: In this paper, the authors studied the behavior of the general nonparametric estimate for the unknown regression function g, where the weight function wni is of the form wni(x) = wni (x; xi(n), …, xn(n)).
89 citations
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TL;DR: This work has revealed the molecular rules governing PLpro substrate specificity and provides a framework for development of inhibitors with potential therapeutic value or drug repositioning.
Abstract: In December 2019, the first cases of a novel coronavirus infection causing COVID-19 were diagnosed in Wuhan, China. Viral Papain-Like cysteine protease (PLpro, NSP3) is essential for SARS-CoV-2 replication and represents a promising target for the development of antiviral drugs. Here, we used a combinatorial substrate library containing natural and a wide variety of nonproteinogenic amino acids and performed comprehensive activity profiling of SARS-CoV-2-PLpro. On the scaffold of best hits from positional scanning we designed optimal fluorogenic substrates and irreversible inhibitors with a high degree of selectivity for SARS PLpro variants versus other proteases. We determined crystal structures of two of these inhibitors (VIR250 and VIR251) in complex with SARS-CoV-2-PLpro which reveals their inhibitory mechanisms and provides a structural basis for the observed substrate specificity profiles. Lastly, we demonstrate that SARS-CoV-2-PLpro harbors deISGylating activities similar to SARS-CoV-1-PLpro but its ability to hydrolyze K48-linked Ub chains is diminished, which our sequence and structure analysis provides a basis for. Altogether this work has revealed the molecular rules governing PLpro substrate specificity and provides a framework for development of inhibitors with potential therapeutic value or drug repositioning.
88 citations
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TL;DR: Laccase isolated from Trametes versicolor was immobilized in polyacrylamide gel and used for the conversion of 4-methyl-3-hydroxyanthranilic acid to 2-amino-4,6-dimethyl-3
88 citations
Authors
Showing all 13239 results
Name | H-index | Papers | Citations |
---|---|---|---|
Krzysztof Palczewski | 114 | 631 | 46909 |
Claude B. Sirlin | 98 | 475 | 33456 |
Marek Czosnyka | 88 | 747 | 29117 |
Alfred Forchel | 85 | 1358 | 34771 |
Jerzy Leszczynski | 78 | 993 | 27231 |
Kim R. Dunbar | 74 | 470 | 20262 |
Massimo Olivucci | 67 | 292 | 14880 |
Nitesh V. Chawla | 61 | 388 | 41365 |
Edward R. T. Tiekink | 60 | 1967 | 21052 |
Bobby G. Sumpter | 60 | 619 | 23583 |
Wieslaw Krolikowski | 59 | 504 | 12836 |
Pappannan Thiyagarajan | 59 | 245 | 10650 |
Marek Samoc | 58 | 401 | 11171 |
Lutz Mädler | 58 | 232 | 27800 |
Rafał Weron | 58 | 285 | 12058 |