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Institution

Wrocław University of Technology

EducationWrocław, Poland
About: Wrocław University of Technology is a education organization based out in Wrocław, Poland. It is known for research contribution in the topics: Laser & Fuzzy logic. The organization has 13115 authors who have published 31279 publications receiving 338694 citations.


Papers
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Journal ArticleDOI
01 Jan 2002-Fuel
TL;DR: In this article, the structure of vitrinites, liptinites and fusinites isolated from different rank coals (77.0-91.5%C) using a centrifugal float-sink procedure.

84 citations

Journal ArticleDOI
TL;DR: The use of TR-FRET screening is reported to successfully identify a novel capsid inhibitor, ebselen, validating HIV-1 capsid as a promising target for drug development.
Abstract: The human immunodeficiency virus type 1 (HIV-1) capsid plays crucial roles in HIV-1 replication and thus represents an excellent drug target. We developed a high-throughput screening method based on a time-resolved fluorescence resonance energy transfer (HTS-TR-FRET) assay, using the C-terminal domain (CTD) of HIV-1 capsid to identify inhibitors of capsid dimerization. This assay was used to screen a library of pharmacologically active compounds, composed of 1,280 in vivo-active drugs, and identified ebselen [2-phenyl-1,2-benzisoselenazol-3(2H)-one], an organoselenium compound, as an inhibitor of HIV-1 capsid CTD dimerization. Nuclear magnetic resonance (NMR) spectroscopic analysis confirmed the direct interaction of ebselen with the HIV-1 capsid CTD and dimer dissociation when ebselen is in 2-fold molar excess. Electrospray ionization mass spectrometry revealed that ebselen covalently binds the HIV-1 capsid CTD, likely via a selenylsulfide linkage with Cys198 and Cys218. This compound presents anti-HIV activity in single and multiple rounds of infection in permissive cell lines as well as in primary peripheral blood mononuclear cells. Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process. This compound also blocks infection of other retroviruses, such as Moloney murine leukemia virus and simian immunodeficiency virus, but displays no inhibitory activity against hepatitis C and influenza viruses. This study reports the use of TR-FRET screening to successfully identify a novel capsid inhibitor, ebselen, validating HIV-1 capsid as a promising target for drug development.

84 citations

Journal ArticleDOI
28 Aug 2013
TL;DR: Using methods of entropy in ergodic theory, the authors proved as in the title that entropy can be used to prove the existence of an Eulerian Ego-Ego.
Abstract: Using methods of entropy in ergodic theory, we prove as in the title.

84 citations

Journal ArticleDOI
TL;DR: In this paper, several polish herbal medicaments were studied to determine trace elements and their bioavailable forms by the use of the ICP-AES method and the results were considered in terms of the utility of the natural herbal medicament as a source of minerals indispensable for proper functioning of the human organism.

84 citations

Journal ArticleDOI
TL;DR: In this article, a new oxy-fuel H2 generation process with CO2 avoidance is provided, which utilizes mass recirculation of CO and H2O to the oxyforming reactor.

83 citations


Authors

Showing all 13239 results

NameH-indexPapersCitations
Krzysztof Palczewski11463146909
Claude B. Sirlin9847533456
Marek Czosnyka8874729117
Alfred Forchel85135834771
Jerzy Leszczynski7899327231
Kim R. Dunbar7447020262
Massimo Olivucci6729214880
Nitesh V. Chawla6138841365
Edward R. T. Tiekink60196721052
Bobby G. Sumpter6061923583
Wieslaw Krolikowski5950412836
Pappannan Thiyagarajan5924510650
Marek Samoc5840111171
Lutz Mädler5823227800
Rafał Weron5828512058
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202372
2022231
20211,579
20201,769
20191,753
20181,963