Institution
Wrocław University of Technology
Education•Wrocław, Poland•
About: Wrocław University of Technology is a education organization based out in Wrocław, Poland. It is known for research contribution in the topics: Laser & Fuzzy logic. The organization has 13115 authors who have published 31279 publications receiving 338694 citations.
Topics: Laser, Fuzzy logic, Quantum dot, Optical fiber, Photoluminescence
Papers published on a yearly basis
Papers
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TL;DR: The synthesis and screening of HyCoSuL for human caspases and legumain is described and possible modifications and adaptations of this approach are discussed that make it a useful tool for developing highly active and selective reagents for a wide variety of proteolytic enzymes.
Abstract: Many biologically and chemically based approaches have been developed to design highly active and selective protease substrates and probes. It is, however, difficult to find substrate sequences that are truly selective for any given protease, as different proteases can demonstrate a great deal of overlap in substrate specificities. In some cases, better enzyme selectivity can be achieved using peptide libraries containing unnatural amino acids such as the hybrid combinatorial substrate library (HyCoSuL), which uses both natural and unnatural amino acids. HyCoSuL is a combinatorial library of tetrapeptides containing amino acid mixtures at the P4-P2 positions, a fixed amino acid at the P1 position, and an ACC (7-amino-4-carbamoylmethylcoumarin) fluorescent tag occupying the P1' position. Once the peptide is recognized and cleaved by a protease, the ACC is released and produces a readable fluorescence signal. Here, we describe the synthesis and screening of HyCoSuL for human caspases and legumain. We also discuss possible modifications and adaptations of this approach that make it a useful tool for developing highly active and selective reagents for a wide variety of proteolytic enzymes. The protocol can be divided into three major parts: (i) solid-phase synthesis of the fluorescence-labeled HyCoSuL, (ii) screening of protease P4-P2 preferences, and (iii) synthesis of the optimized activity probes equipped with an AOMK (acyloxymethyl ketone) reactive group and a biotin label for easy detection. Beginning with the library design, the entire protocol can be completed in 4-8 weeks (HyCoSuL synthesis: 3-5 weeks; HyCoSuL screening per enzyme: 4-8 d; and activity-based probe synthesis: 1-2 weeks).
75 citations
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30 Nov 2006TL;DR: This paper presents several extensions of this paradigm that make sanitizable signatures even more useful, including one that allows the censor to present only a constant number of versions of the sanitized message and another that provides so-called strong transparency.
Abstract: Sanitizable signatures introduced by Ateniese et al. is a powerful and fairly practical tool that enables an authorised party called the censor to modify designated parts of a signed message in an arbitrary way without interacting with the signer. In our paper we present several extensions of this paradigm that make sanitizable signatures even more useful. First of all we show how to limit the censor's abilities to modify mutable parts of a signed message to a predetermined set of strings. In our next proposal we show how to construct a scheme wherein the censor can insert an arbitrary string into a document, but this must be the same string in all designated places. We also present a construction based on a sanitizable signature that allows the censor to present only a constant number of versions of the sanitized message. Another extension provides so-called strong transparency. In this case the verifier does not know which parts of the message could have been modified. Finally, we point out new applications of sanitizable signatures based on combining them with time released cryptography techniques.
75 citations
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TL;DR: In this article, the authors investigated the link between pyrolysis conditions, the chemical and mineralogical composition of their products, and the benefits of pyroolysis in the waste management sector.
75 citations
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TL;DR: In this article, the authors provide a review of the incentives and barriers of a successful adoption of innovative energy services (IES) in the energy market and propose some strategies that could boost the diffusion of IES.
Abstract: The paper provides a review of the incentives and barriers of a successful adoption of innovative energy services (IES) in the energy market. Although IES can have different attributes and roles, they still have a lot in common with each other. On the other hand, the literature suggests that to achieve large market penetration rates of IES, the consumers must be firstly aware of them. They must be also supported by the access to reliable information and advice to limit their confusion of choice. The perceived difficulty of adoption has to be reduced to encourage consumers to get interested in the services. Also the distribution channels of the innovations, namely social influence in the consumers’ social networks and advertisement in mass-media should be effectively used to boost the diffusion. We analyze a great number of research studies, field experiments and mathematical models in order to firstly summarize the findings related to incentives and barriers of IES adoption among customers, then to recognize recent trends in examining these services and modeling and finally to propose some strategies that could boost the diffusion of IES. We argue that to overcome the barriers of adoption, the entities involved in creating and offering IES (e.g. policy makers, energy suppliers and power system operators) should find a way to offer and promote these services together. Such a strategy can bring a synergic effect and increase the financial and non-financial benefits to the consumers and hence increase their interest and engagement.
75 citations
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TL;DR: A quantum-kinetic theory of the excitation transfer in a quantum dot molecule is presented and the consistent Markovian limit for the system kinetics is derived, which leads to a description in terms of a single transfer rate for weak coupling.
Abstract: We present a quantum-kinetic theory of the excitation transfer in a quantum dot molecule. We derive the consistent Markovian limit for the system kinetics, which leads to a description in terms of a single transfer rate for weak coupling. We show that the transfer rate is a strongly varying, nonmonotonic function of the spatial separation and energy mismatch between the dots.
75 citations
Authors
Showing all 13239 results
Name | H-index | Papers | Citations |
---|---|---|---|
Krzysztof Palczewski | 114 | 631 | 46909 |
Claude B. Sirlin | 98 | 475 | 33456 |
Marek Czosnyka | 88 | 747 | 29117 |
Alfred Forchel | 85 | 1358 | 34771 |
Jerzy Leszczynski | 78 | 993 | 27231 |
Kim R. Dunbar | 74 | 470 | 20262 |
Massimo Olivucci | 67 | 292 | 14880 |
Nitesh V. Chawla | 61 | 388 | 41365 |
Edward R. T. Tiekink | 60 | 1967 | 21052 |
Bobby G. Sumpter | 60 | 619 | 23583 |
Wieslaw Krolikowski | 59 | 504 | 12836 |
Pappannan Thiyagarajan | 59 | 245 | 10650 |
Marek Samoc | 58 | 401 | 11171 |
Lutz Mädler | 58 | 232 | 27800 |
Rafał Weron | 58 | 285 | 12058 |