Institution
Wrocław University of Technology
Education•Wrocław, Poland•
About: Wrocław University of Technology is a education organization based out in Wrocław, Poland. It is known for research contribution in the topics: Laser & Fuzzy logic. The organization has 13115 authors who have published 31279 publications receiving 338694 citations.
Topics: Laser, Fuzzy logic, Quantum dot, Optical fiber, Photoluminescence
Papers published on a yearly basis
Papers
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TL;DR: It is demonstrated that cleavage of the catalytic domain of caspase 8 is crucial for its activity in the context of activation by homodimerization, and use of FLIP(L) as a partner for caspases 8 in dimerization-induced activation rescues the requirement for intersubunit linker proteolysis in both protomers.
Abstract: Caspase 8 is an initiator caspase that is activated by death receptors to initiate the extrinsic pathway of apoptosis. Caspase 8 activation involves dimerization and subsequent interdomain autoprocessing of caspase 8 zymogens, and recently published work has established that elimination of the autoprocessing site of caspase 8 abrogates its pro-apoptotic function while leaving its proliferative function intact. The observation that the developmental abnormalities of caspase 8-deficient mice are shared by mice lacking the dimerization adapter FADD (Fas-associated death domain) or the caspase paralogue FLIP(L) [FLICE (FADD-like interleukin 1β-converting enzyme)-inhibitory protein, long form] has led to the hypothesis that FADD-dependent formation of heterodimers between caspase 8 and FLIP(L) could mediate the developmental role of caspase 8. In the present study, using an inducible dimerization system we demonstrate that cleavage of the catalytic domain of caspase 8 is crucial for its activity in the context of activation by homodimerization. However, we find that use of FLIP(L) as a partner for caspase 8 in dimerization-induced activation rescues the requirement for intersubunit linker proteolysis in both protomers. Moreover, before processing, caspase 8 in complex with FLIP(L) does not generate a fully active enzyme, but an attenuated species able to process only selected natural substrates. Based on these results we propose a mechanism of caspase 8 activation by dimerization in the presence of FLIP(L), as well as a mechanism of caspase 8 functional divergence in apoptotic and non-apoptotic pathways.
195 citations
TL;DR: Fuzzy equivalents of all the classical capital budgeting (investment choice) methods are generalised or proposed to evaluate and compare projects in which the cash ows, duration time and required rate of return are given imprecisely, in the form of a fuzzy number.
195 citations
TL;DR: In this paper, a method of identifying fouling mechanisms applicable to microfiltration in general has been developed and simultaneous experiments in both dead-end and cross-flow modes have been performed at various pressures, and in the latter case at different crossflow velocities.
194 citations
TL;DR: Results obtained show that oversampling concrete types of examples may lead to a significant improvement over standard multi-class preprocessing that do not consider the importance of example types.
194 citations
193 citations
Authors
Showing all 13239 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Krzysztof Palczewski | 114 | 631 | 46909 |
| Claude B. Sirlin | 98 | 475 | 33456 |
| Marek Czosnyka | 88 | 747 | 29117 |
| Alfred Forchel | 85 | 1358 | 34771 |
| Jerzy Leszczynski | 78 | 993 | 27231 |
| Kim R. Dunbar | 74 | 470 | 20262 |
| Massimo Olivucci | 67 | 292 | 14880 |
| Nitesh V. Chawla | 61 | 388 | 41365 |
| Edward R. T. Tiekink | 60 | 1967 | 21052 |
| Bobby G. Sumpter | 60 | 619 | 23583 |
| Wieslaw Krolikowski | 59 | 504 | 12836 |
| Pappannan Thiyagarajan | 59 | 245 | 10650 |
| Marek Samoc | 58 | 401 | 11171 |
| Lutz Mädler | 58 | 232 | 27800 |
| Rafał Weron | 58 | 285 | 12058 |