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Institution

Wuhan University

EducationWuhan, China
About: Wuhan University is a education organization based out in Wuhan, China. It is known for research contribution in the topics: Population & Feature extraction. The organization has 92849 authors who have published 92882 publications receiving 1691049 citations. The organization is also known as: WHU & Wuhan College.


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Journal ArticleDOI
TL;DR: Although DNA methylation biomarker possesses potential contributing to precision medicine, there are still limitations to be overcome before it reaches clinical setting and the future use in clinic was predicted.
Abstract: Cancer initiation and proliferation is regulated by both epigenetic and genetic events with epigenetic modifications being increasingly identified as important targets for cancer research. DNA methylation catalyzed by DNA methyltransferases (DNMTs) is one of the essential epigenetic mechanisms that control cell proliferation, apoptosis, differentiation, cell cycle, and transformation in eukaryotes. Recent progress in epigenetics revealed a deeper understanding of the mechanisms of tumorigenesis and provided biomarkers for early detection, diagnosis, and prognosis in cancer patients. Although DNA methylation biomarker possesses potential contributing to precision medicine, there are still limitations to be overcome before it reaches clinical setting. Hence, the current status of DNA methylation biomarkers was reviewed and the future use in clinic was also predicted.

255 citations

Journal ArticleDOI
TL;DR: The detailed and comprehensive understanding of structure–composition–performance relationship of materials is provided and the advantages and disadvantages of the materials for use in SIBs are shown.
Abstract: Sodium ion batteries (SIBs) have been considered as a promising alternative for the next generation of electric storage systems due to their similar electrochemistry to Li-ion batteries and the low cost of sodium resources. Exploring appropriate electrode materials with decent electrochemical performance is the key issue for development of sodium ion batteries. Due to the high structural stability, facile reaction mechanism and rich structural diversity, phosphate framework materials have attracted increasing attention as promising electrode materials for sodium ion batteries. Herein, we review the latest advances and progresses in the exploration of phosphate framework materials especially related to single-phosphates, pyrophosphates and mixed-phosphates. We provide the detailed and comprehensive understanding of structure-composition-performance relationship of materials and try to show the advantages and disadvantages of the materials for use in SIBs. In addition, some new perspectives about phosphate framework materials for SIBs are also discussed. Phosphate framework materials will be a competitive and attractive choice for use as electrodes in the next-generation of energy storage devices.

255 citations

Journal ArticleDOI
TL;DR: In this paper, the adsorption isotherms of methylene blue (MB) on the HKUST-1/GO composite followed both the Freundlich isotherm and the Langmuirisotherm.
Abstract: The adsorption of methylene blue (MB) from aqueous solution on a HKUST-1/GO (MOFs : HKUST-1) composite was studied in view of the adsorption isotherm, kinetics and regeneration of the sorbent. The adsorption isotherms of methylene blue (MB) on the HKUST-1/GO composite followed both the Freundlich isotherm and the Langmuir isotherm. Adsorption kinetics and thermodynamic parameters were determined from the experimental data. The used HKUST-1/GO could be regenerated by acetone, so it can be recycled for reuse. The high adsorption capacity and excellent reusability make HKUST-1/GO attractive for the removal of MB from aqueous solution.

255 citations

Journal ArticleDOI
19 Jan 2021-JAMA
TL;DR: In this article, the authors investigated whether endovascular thrombectomy alone is non-inferior to intravenous alteplase followed by end-ovascular surgery for achieving functional independence at 90 days among patients with ischemic stroke.
Abstract: Importance For patients with large vessel occlusion strokes, it is unknown whether endovascular treatment alone compared with intravenous thrombolysis plus endovascular treatment (standard treatment) can achieve similar functional outcomes. Objective To investigate whether endovascular thrombectomy alone is noninferior to intravenous alteplase followed by endovascular thrombectomy for achieving functional independence at 90 days among patients with large vessel occlusion stroke. Design, Setting, and Participants Multicenter, randomized, noninferiority trial conducted at 33 stroke centers in China. Patients (n = 234) were 18 years or older with proximal anterior circulation intracranial occlusion strokes within 4.5 hours from symptoms onset and eligible for intravenous thrombolysis. Enrollment took place from May 20, 2018, to May 2, 2020. Patients were enrolled and followed up for 90 days (final follow-up was July 22, 2020). Interventions A total of 116 patients were randomized to the endovascular thrombectomy alone group and 118 patients to combined intravenous thrombolysis and endovascular thrombectomy group. Main Outcomes and Measures The primary end point was the proportion of patients achieving functional independence at 90 days (defined as score 0-2 on the modified Rankin Scale; range, 0 [no symptoms] to 6 [death]). The noninferiority margin was −10%. Safety outcomes included the incidence of symptomatic intracerebral hemorrhage within 48 hours and 90-day mortality. Results The trial was stopped early because of efficacy when 234 of a planned 970 patients had undergone randomization. All 234 patients who were randomized (mean age, 68 years; 102 women [43.6%]) completed the trial. At the 90-day follow-up, 63 patients (54.3%) in the endovascular thrombectomy alone group vs 55 (46.6%) in the combined treatment group achieved functional independence at the 90-day follow-up (difference, 7.7%, 1-sided 97.5% CI, −5.1% to ∞)Pfor noninferiority = .003). No significant between-group differences were detected in symptomatic intracerebral hemorrhage (6.1% vs 6.8%; difference, −0.8%; 95% CI, −7.1% to 5.6%) and 90-day mortality (17.2% vs 17.8%; difference, −0.5%; 95% CI, −10.3% to 9.2%). Conclusions and Relevance Among patients with ischemic stroke due to proximal anterior circulation occlusion within 4.5 hours from onset, endovascular treatment alone, compared with intravenous alteplase plus endovascular treatment, met the prespecified statistical threshold for noninferiority for the outcome of 90-day functional independence. These findings should be interpreted in the context of the clinical acceptability of the selected noninferiority threshold. Trial Registration Chinese Clinical Trial Registry:ChiCTR-IOR-17013568

255 citations

Journal ArticleDOI
Peng He1, Bing Li1, Xiao Liu1, Jun Chen1, Yutao Ma1 
TL;DR: The experimental results indicate that the choice of training data for defect prediction should depend on the specific requirement of accuracy and the minimum metric subset can be identified to facilitate the procedure of general defect prediction with acceptable loss of prediction precision in practice.
Abstract: ContextSoftware defect prediction plays a crucial role in estimating the most defect-prone components of software, and a large number of studies have pursued improving prediction accuracy within a project or across projects. However, the rules for making an appropriate decision between within- and cross-project defect prediction when available historical data are insufficient remain unclear. ObjectiveThe objective of this work is to validate the feasibility of the predictor built with a simplified metric set for software defect prediction in different scenarios, and to investigate practical guidelines for the choice of training data, classifier and metric subset of a given project. MethodFirst, based on six typical classifiers, three types of predictors using the size of software metric set were constructed in three scenarios. Then, we validated the acceptable performance of the predictor based on Top-k metrics in terms of statistical methods. Finally, we attempted to minimize the Top-k metric subset by removing redundant metrics, and we tested the stability of such a minimum metric subset with one-way ANOVA tests. ResultsThe study has been conducted on 34 releases of 10 open-source projects available at the PROMISE repository. The findings indicate that the predictors built with either Top-k metrics or the minimum metric subset can provide an acceptable result compared with benchmark predictors. The guideline for choosing a suitable simplified metric set in different scenarios is presented in Table 12. ConclusionThe experimental results indicate that (1) the choice of training data for defect prediction should depend on the specific requirement of accuracy; (2) the predictor built with a simplified metric set works well and is very useful in case limited resources are supplied; (3) simple classifiers (e.g., Naive Bayes) also tend to perform well when using a simplified metric set for defect prediction; and (4) in several cases, the minimum metric subset can be identified to facilitate the procedure of general defect prediction with acceptable loss of prediction precision in practice.

255 citations


Authors

Showing all 93441 results

NameH-indexPapersCitations
Jing Wang1844046202769
Jiaguo Yu178730113300
Lei Jiang1702244135205
Gang Chen1673372149819
Omar M. Yaghi165459163918
Xiang Zhang1541733117576
Yi Yang143245692268
Thomas P. Russell141101280055
Jun Chen136185677368
Lei Zhang135224099365
Chuan He13058466438
Han Zhang13097058863
Lei Zhang130231286950
Zhen Li127171271351
Chao Zhang127311984711
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023286
20221,139
20219,716
20209,672
20197,977
20186,629