Wuhan University

About: Wuhan University is a education organization based out in Wuhan, China. It is known for research contribution in the topics: Population & Feature extraction. The organization has 92849 authors who have published 92882 publications receiving 1691049 citations. The organization is also known as: WHU & Wuhan College.

A multifunctional metal–organic framework based tumor targeting drug delivery system for cancer therapy

Abstract: Drug delivery systems (DDSs) with biocompatibility and precise drug delivery are eagerly needed to overcome the paradox in chemotherapy that high drug doses are required to compensate for the poor biodistribution of drugs with frequent dose-related side effects. In this work, we reported a metal-organic framework (MOF) based tumor targeting DDS developed by a one-pot, and organic solvent-free "green" post-synthetic surface modification procedure, starting from the nanoscale MOF MIL-101. Owing to the multifunctional surface coating, premature drug release from this DDS was prevented. Due to the pH responsive benzoic imine bond and the redox responsive disulfide bond at the modified surface, this DDS exhibited tumor acid environment enhanced cellular uptake and intracellular reducing environment triggered drug release. In vitro and in vivo results showed that DOX loaded into this DDS exhibited effective cancer cell inhibition with much reduced side effects.

Effects of Angiotensin II Receptor Blockers and ACE (Angiotensin-Converting Enzyme) Inhibitors on Virus Infection, Inflammatory Status, and Clinical Outcomes in Patients With COVID-19 and Hypertension: A Single-Center Retrospective Study.

Abstract: With the capability of inducing elevated expression of ACE2 (angiotensin-converting enzyme 2), the cellular receptor for severe acute respiratory syndrome coronavirus 2, angiotensin II receptor blockers (ARBs) or ACE inhibitors treatment may have a controversial role in both facilitating virus infection and reducing pathogenic inflammation We aimed to evaluate the effects of ARBs/ACE inhibitors on coronavirus disease 2019 (COVID-19) in a retrospective, single-center study One hundred twenty-six patients with COVID-19 and preexisting hypertension at Hubei Provincial Hospital of Traditional Chinese Medicine in Wuhan from January 5 to February 22, 2020, were retrospectively allocated to ARBs/ACE inhibitors group (n=43) and non-ARBs/ACE inhibitors group (n=83) according to their antihypertensive medication One hundred twenty-five age- and sex-matched patients with COVID-19 without hypertension were randomly selected as nonhypertension controls In addition, the medication history of 1942 patients with hypertension that were admitted to Hubei Provincial Hospital of Traditional Chinese Medicine from November 1 to December 31, 2019, before the COVID-19 outbreak were also reviewed for external comparison Epidemiological, demographic, clinical, and laboratory data were collected, analyzed, and compared between these groups The frequency of ARBs/ACE inhibitors usage in patients with hypertension with or without COVID-19 were comparable Among patients with COVID-19 and hypertension, those received either ARBs/ACE inhibitors or non-ARBs/ACE inhibitors had comparable blood pressure However, ARBs/ACE inhibitors group had significantly lower concentrations of hs-CRP (high-sensitivity C-reactive protein; P=0049) and PCT (procalcitonin, P=0008) Furthermore, a lower proportion of critical patients (93% versus 229%; P=0061) and a lower death rate (47% versus 133%; P=0216) were observed in ARBs/ACE inhibitors group than non-ARBs/ACE inhibitors group, although these differences failed to reach statistical significance Our findings thus support the use of ARBs/ACE inhibitors in patients with COVID-19 and preexisting hypertension

A low cost, all-organic Na-ion Battery Based on Polymeric Cathode and Anode

Abstract: Current battery systems have severe cost and resource restrictions, difficultly to meet the large scale electric storage applications. Herein, we report an all-organic Na-ion battery using p-dopable polytriphenylamine as cathode and n-type redox-active poly(anthraquinonyl sulphide) as anode, excluding the use of transition-metals as in conventional electrochemical batteries. Such a Na-ion battery can work well with a voltage output of 1.8 V and realize a considerable specific energy of 92 Wh kg(-1). Due to the structural flexibility and stability of the redox-active polymers, this battery has a superior rate capability with 60% capacity released at a very high rate of 16 C (3200 mA g(-1)) and also exhibit an excellent cycling stability with 85% capacity retention after 500 cycles at 8 C rate. Most significantly, this type of all-organic batteries could be made from renewable and earth-abundant materials, thus offering a new possibility for widespread energy storage applications.

Single InAs Nanowire Room-Temperature Near-Infrared Photodetectors

Abstract: Here we report InAs nanowire (NW) near-infrared photodetectors having a detection wavelength up to ∼1.5 μm. The single InAs NW photodetectors displayed minimum hysteresis with a high Ion/Ioff ratio of 105. At room temperature, the Schottky–Ohmic contacted photodetectors had an external photoresponsivity of ∼5.3 × 103 AW–1, which is ∼300% larger than that of Ohmic–Ohmic contacted detectors (∼1.9 × 103 AW–1). A large enhancement in photoresponsivity (∼300%) had also been achieved in metal Au-cluster-decorated InAs NW photodetectors due to the formation of Schottky junctions at the InAs/Au cluster contacts. The photocurrent decreased when the photodetectors were exposed to ambient atmosphere because of the high surface electron concentration and rich surface defect states in InAs NWs. A theoretical model based on charge transfer and energy band change is proposed to explain this observed performance. To suppress the negative effects of surface defect states and atmospheric molecules, new InAs NW photodetecto...