Institution
Wuhan University
Education•Wuhan, China•
About: Wuhan University is a education organization based out in Wuhan, China. It is known for research contribution in the topics: Population & Feature extraction. The organization has 92849 authors who have published 92882 publications receiving 1691049 citations. The organization is also known as: WHU & Wuhan College.
Papers published on a yearly basis
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TL;DR: Postmortem examinations of lung, liver, and heart in four patients who died of COVID-19 pneumonia show advanced diffuse alveolar damage, as well as superimposed bacterial pneumonia in some patients.
755 citations
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TL;DR: In this depictive study of 85 fatal cases of COVID-19, most cases were males aged over 50 years with noncommunicable chronic diseases, and the majority of the patients died of multiple organ failure.
Abstract: Rationale: The global death toll from coronavirus disease (COVID-19) virus as of May 12, 2020, exceeds 286,000. The risk factors for death were attributed to advanced age and comorbidities but have not been accurately defined.Objectives: To report the clinical features of 85 fatal cases of COVID-19 in two hospitals in Wuhan.Methods: Medical records were collected of 85 fatal cases of COVID-19 between January 9, 2020, and February 15, 2020. Information recorded included medical history, exposure history, comorbidities, symptoms, signs, laboratory findings, computed tomographic scans, and clinical management.Measurements and Main Results: The median age of the patients was 65.8 years, and 72.9% were male. Common symptoms were fever (78 [91.8%]), shortness of breath (50 [58.8%]), fatigue (50 [58.8%]), and dyspnea (60 [70.6%]). Hypertension, diabetes, and coronary heart disease were the most common comorbidities. Notably, 81.2% of patients had very low eosinophil counts on admission. Complications included respiratory failure (80 [94.1%]), shock (69 [81.2%]), acute respiratory distress syndrome (63 [74.1%]), and arrhythmia (51 [60%]), among others. Most patients received antibiotic (77 [90.6%]), antiviral (78 [91.8%]), and glucocorticoid (65 [76.5%]) treatments. A total of 38 (44.7%) and 33 (38.8%) patients received intravenous immunoglobulin and IFN-α2b, respectively.Conclusions: In this depictive study of 85 fatal cases of COVID-19, most cases were males aged over 50 years with noncommunicable chronic diseases. The majority of the patients died of multiple organ failure. Early onset of shortness of breath may be used as an observational symptom for COVID-19 exacerbations. Eosinophilopenia may indicate a poor prognosis. A combination of antimicrobial drugs did not offer considerable benefit to the outcome of this group of patients.
749 citations
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University of Oxford1, Virginia Commonwealth University2, Capital Medical University3, Nanjing Medical University4, Hebei Medical University5, Harbin Medical University6, Shantou University7, Sichuan University8, Sun Yat-sen University9, Chongqing University10, Jinan University11, Xi'an Jiaotong University12, Shanxi Medical University13, Zhengzhou University14, Lanzhou University15, Central South University16, Jiangsu University17, Wuhan University18, Zhejiang Chinese Medical University19, China Medical University (PRC)20, Kanazawa Medical University21, Tianjin First Center Hospital22, Tongji University23, Fourth Military Medical University24, Max Planck Society25, Shanghai Jiao Tong University26, Fudan University27, Peking Union Medical College28, University of Copenhagen29, Macau University of Science and Technology30, King Abdulaziz University31, East China Normal University32
TL;DR: Using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, two loci contributing to risk of MDD on chromosome 10 are identified: one near the SIRT1 gene and the other in an intron of the LHPP gene.
Abstract: Genomic analysis of 5,303 Chinese women with recurrent major depressive disorder (MDD) enables the identification and replication of two genome-wide significant loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene; the other in an intron of the LHPP gene.
745 citations
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TL;DR: Among patients with COVID-19, the use of HCQ could significantly shorten TTCR and promote the absorption of pneumonia.
Abstract: Aims Studies have indicated that chloroquine (CQ) shows antagonism against COVID-19 in vitro. However, evidence regarding its effects in patients is limited. This study aims to evaluate the efficacy of hydroxychloroquine (HCQ) in the treatment of patients with COVID-19. Main methods From February 4 to February 28, 2020, 62 patients suffering from COVID-19 were diagnosed and admitted to Renmin Hospital of Wuhan University. All participants were randomized in a parallel-group trial, 31 patients were assigned to receive an additional 5-day HCQ (400 mg/d) treatment, Time to clinical recovery (TTCR), clinical characteristics, and radiological results were assessed at baseline and 5 days after treatment to evaluate the effect of HCQ. Key findings For the 62 COVID-19 patients, 46.8% (29 of 62) were male and 53.2% (33 of 62) were female, the mean age was 44.7 (15.3) years. No difference in the age and sex distribution between the control group and the HCQ group. But for TTCR, the body temperature recovery time and the cough remission time were significantly shortened in the HCQ treatment group. Besides, a larger proportion of patients with improved pneumonia in the HCQ treatment group (80.6%, 25 of 31) compared with the control group (54.8%, 17 of 31). Notably, all 4 patients progressed to severe illness that occurred in the control group. However, there were 2 patients with mild adverse reactions in the HCQ treatment group. Significance Among patients with COVID-19, the use of HCQ could significantly shorten TTCR and promote the absorption of pneumonia. Trial registration URL: https://www.clinicaltrials.gov/. The unique identifier: ChiCTR2000029559.
742 citations
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TL;DR: It is shown that UPDs are rather stable in time and space, and can be estimated with high accuracy and reliability through a statistical analysis of the ambiguities estimated from a reference network.
Abstract: Precise Point Positioning (PPP) has been demonstrated to be a powerful tool in geodetic and geodynamic applications. Although its accuracy is almost comparable with network solutions, the east component of the PPP results is still to be improved by integer ambiguity fixing, which is, up to now, prevented by the presence of the uncalibrated phase delays (UPD) originating in the receivers and satellites. In this paper, it is shown that UPDs are rather stable in time and space, and can be estimated with high accuracy and reliability through a statistical analysis of the ambiguities estimated from a reference network. An approach is implemented to estimate the fractional parts of the single-difference (SD) UPDs between satellites in wide- and narrow-lane from a global reference network. By applying the obtained SD-UPDs as corrections to the SD-ambiguities at a single station, the corrected SD-ambiguities have a naturally integer feature and can therefore be fixed to integer values as usually done for the double-difference ones in the network mode. With data collected at 450 stations of the International GNSS Service (IGS) through days 106 to 119 in 2006, the efficiency of the presented ambiguity-fixing strategy is validated using IGS Final products. On average, more than 80% of the independent ambiguities could be fixed reliably, which leads to an improvement of about 27% in the repeatability and 30% in the agreement with the IGS weekly solutions for the east component of station coordinates, compared with the real-valued solutions.
741 citations
Authors
Showing all 93441 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jing Wang | 184 | 4046 | 202769 |
Jiaguo Yu | 178 | 730 | 113300 |
Lei Jiang | 170 | 2244 | 135205 |
Gang Chen | 167 | 3372 | 149819 |
Omar M. Yaghi | 165 | 459 | 163918 |
Xiang Zhang | 154 | 1733 | 117576 |
Yi Yang | 143 | 2456 | 92268 |
Thomas P. Russell | 141 | 1012 | 80055 |
Jun Chen | 136 | 1856 | 77368 |
Lei Zhang | 135 | 2240 | 99365 |
Chuan He | 130 | 584 | 66438 |
Han Zhang | 130 | 970 | 58863 |
Lei Zhang | 130 | 2312 | 86950 |
Zhen Li | 127 | 1712 | 71351 |
Chao Zhang | 127 | 3119 | 84711 |