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Institution

Wuhan University

EducationWuhan, China
About: Wuhan University is a education organization based out in Wuhan, China. It is known for research contribution in the topics: Population & Feature extraction. The organization has 92849 authors who have published 92882 publications receiving 1691049 citations. The organization is also known as: WHU & Wuhan College.


Papers
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Journal ArticleDOI
TL;DR: Wang et al. as mentioned in this paper investigated the characteristics of patients with refractory CoV-2-infected pneumonia (COVID-19) and found that nearly 50% patients could not reach obvious clinical and radiological remission within 10 days after hospitalization.
Abstract: Background Since December 2019, novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. This study aimed to clarify the characteristics of patients with refractory COVID-19. Methods In this retrospective single-center study, we included 155 consecutive patients with confirmed COVID-19 in Zhongnan Hospital of Wuhan University from January 1st to February 5th. The cases were divided into general and refractory COVID-19 groups according to the clinical efficacy after hospitalization, and the difference between groups were compared. Results Compared with general COVID-19 patients (45.2%), refractory patients had an older age, male sex, more underlying comorbidities, lower incidence of fever, higher levels of maximum temperature among fever cases, higher incidence of breath shortness and anorexia, severer disease assessment on admission, high levels of neutrophil, aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and C-reactive protein, lower levels of platelets and albumin, and higher incidence of bilateral pneumonia and pleural effusion (P Conclusion Nearly 50% COVID-19 patients could not reach obvious clinical and radiological remission within 10 days after hospitalization. The patients with male sex, anorexia and no fever on admission predicted poor efficacy.

667 citations

Journal ArticleDOI
TL;DR: Treatment options for COVID-19 infection, including antiviral agents, chloroquine and hydroxychloroquine, corticosteroids, antibodies, convalescent plasma transfusion and vaccines, are discussed in this article.

666 citations

Journal ArticleDOI
TL;DR: High-resolution structures of the trimeric MERS- coV and SARS-CoV S proteins in its pre-fusion conformation are presented by single particle cryo-electron microscopy, demonstrating an inherently flexible RBD readily recognized by the receptor.
Abstract: The envelope spike (S) proteins of MERS-CoV and SARS-CoV determine the virus host tropism and entry into host cells, and constitute a promising target for the development of prophylactics and therapeutics. Here, we present high-resolution structures of the trimeric MERS-CoV and SARS-CoV S proteins in its pre-fusion conformation by single particle cryo-electron microscopy. The overall structures resemble that from other coronaviruses including HKU1, MHV and NL63 reported recently, with the exception of the receptor binding domain (RBD). We captured two states of the RBD with receptor binding region either buried (lying state) or exposed (standing state), demonstrating an inherently flexible RBD readily recognized by the receptor. Further sequence conservation analysis of six human-infecting coronaviruses revealed that the fusion peptide, HR1 region and the central helix are potential targets for eliciting broadly neutralizing antibodies.

658 citations

Journal ArticleDOI
TL;DR: The proposed CrackTree method is evaluated on a collection of 206 real pavement images and the experimental results show that the proposed method achieves a better performance than several existing methods.

657 citations


Authors

Showing all 93441 results

NameH-indexPapersCitations
Jing Wang1844046202769
Jiaguo Yu178730113300
Lei Jiang1702244135205
Gang Chen1673372149819
Omar M. Yaghi165459163918
Xiang Zhang1541733117576
Yi Yang143245692268
Thomas P. Russell141101280055
Jun Chen136185677368
Lei Zhang135224099365
Chuan He13058466438
Han Zhang13097058863
Lei Zhang130231286950
Zhen Li127171271351
Chao Zhang127311984711
Network Information
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023286
20221,139
20219,716
20209,672
20197,977
20186,629