Xi'an Jiaotong University

About: Xi'an Jiaotong University is a education organization based out in Xi'an, China. It is known for research contribution in the topics: Heat transfer & Dielectric. The organization has 85440 authors who have published 99682 publications receiving 1579683 citations. The organization is also known as: '''Xi'an Jiaotong University''' & Xi'an Jiao Tong University.

LncRNA-ATB promotes trastuzumab resistance and invasion-metastasis cascade in breast cancer.

Abstract: // Sheng-Jia Shi 1, * , Li-Juan Wang 2, * , Bo Yu 1 , Yun-Hui Li 1 , Yong Jin 1 , Xiao-Zhong Bai 1 1 Department of Administration and Department of Aristogenesis, No. 202 Hospital of PLA, No. 5, Shenyang, 110003, Liaoning Province, P.R. China 2 Department of Oncology, the First Affiliated Hospital of Medical College of Xi’an Jiaotong University, Xi’an, 710061, Shaanxi Province, P.R. China * These authors have contributed equally to this work Correspondence to: Xiao-Zhong Bai, e-mail: baixz2015@163.com Keywords: lnc-ATB, trastuzumab resistance, EMT, TGF-β, breast cancer Received: February 05, 2015 Accepted: February 25, 2015 Published: March 23, 2015 ABSTRACT Trastuzumab resistance is leading cause of mortality in HER2-positive breast cancers, and the role of TGF-β-induced epithelial-mesenchymal transition (EMT) in trastuzumab resistance is well established, but the involvement of lncRNAs in trastuzumab resistance is still unknown. Here, we generated trastuzumab-resistant breast cancer cells with increased invasiveness compared with parental cells, and observed robust epithelial–mesenchymal transition (EMT) and consistently elevated TGF-β signaling in these cells. We identified long noncoding RNA activated by TGF-β (lnc-ATB) was the most remarkably upregulated lncRNA in TR SKBR-3 cells and the tissues of TR breast cancer patients. We found that lnc-ATB could promote trastuzumab resistance and invasion-metastasis cascade in breast cancer by competitively biding miR-200c, up-regulating ZEB1 and ZNF-217, and then inducing EMT. In addition, we also found that the high level of lnc-ATB was correlated with trastuzumab resistance of breast cancer patients. Thus, these findings suggest that lncRNA-ATB, a mediator of TGF-β signaling, could predispose breast cancer patients to EMT and trastuzumab resistance.

The impact of supply chain risk on supply chain integration and company performance: a global investigation

Abstract: Purpose – The purpose of this paper is to empirically explore the relationships among supply chain risks (SCRs), supply chain integration (SCI), and company performance in a global context.Design/methodology/approach – This study is based on the High Performance Manufacturing (HPM) project database collected from 317 manufacturing plants in ten countries and three representative industries (machinery, electronics and transportation components), using structural equation modeling (SEM) methods.Findings – Results show that SCRs, especially supply delivery risk (SDR), are negatively related to SCI. There is a contingent relationship between SCI and performance. Different types of SCI play different roles in improving different types of company performance. Supplier, internal, and customer integration are the most important drivers for schedule attainment, competitive performance, and customer satisfaction, respectively.Originality/value – This study is one of the first empirical studies to explore how SCRs a...